U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170920, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Map4k3provided by RGD
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 3provided by RGD
Primary source
RGD:621280
See related
EnsemblRapid:ENSRNOG00000007172 AllianceGenome:RGD:621280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables SH3 domain binding activity. Predicted to be involved in several processes, including protein phosphorylation; response to UV; and response to tumor necrosis factor. Predicted to be active in cytoplasm. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 225.0), Lung (RPKM 194.0) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Map4k3 in Genome Data Viewer
Location:
6q12
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (20029246..20198583)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (14276623..14446321)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (3276732..3444519, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479322 Neighboring gene uncharacterized LOC102551891 Neighboring gene eukaryotic translation initiation factor 1-like Neighboring gene cyclin-dependent kinase-like 4 Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Roles of Mitogen-Activating Protein Kinase Kinase Kinase Kinase-3 (MAP4K3) in Preterm Skeletal Muscle Satellite Cell Myogenesis and Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation Regulation. Guo CY, et al. Med Sci Monit, 2017 Jul 21. PMID 28731988, Free PMC Article
  2. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Diener K, et al. Proc Natl Acad Sci U S A, 1997 Sep 2. PMID 9275185, Free PMC Article
  3. Enhancement of chondrocyte autophagy is an early response in the degenerative cartilage of the temporomandibular joint to biomechanical dental stimulation. Zhang M, et al. Apoptosis, 2013 Apr. PMID 23386193
  4. Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase. Ramjaun AR, et al. J Biol Chem, 2001 Aug 3. PMID 11384986
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAP4K3 positively regulates preterm skeletal muscle satellite cell myogenesis, but may not regulate mTORC1 activity. MAP4K3 may play a role in mTORC1 full activation in response to leucine.
    Title: Roles of Mitogen-Activating Protein Kinase Kinase Kinase Kinase-3 (MAP4K3) in Preterm Skeletal Muscle Satellite Cell Myogenesis and Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation Regulation.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to UV IEA
Inferred from Electronic Annotation
more info
  
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in response to UV ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
  
involved_in response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mitogen-activated protein kinase kinase kinase kinase 3
Names
GLK
MAPK/ERK kinase kinase kinase 3
MEK kinase kinase 3
MEKKK 3
germinal center kinase-related protein kinase
NP_596898.1
XP_006239718.2
XP_017449508.2
XP_017449509.2
XP_017449510.2
XP_038967654.1
XP_038967655.1
XP_038967656.1
XP_038967657.1
XP_038967658.1
XP_038967659.1
XP_038967660.1
XP_038967661.1
XP_063117574.1
XP_063117575.1
XP_063117576.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133407.1 → NP_596898.1  mitogen-activated protein kinase kinase kinase kinase 3

    See identical proteins and their annotated locations for NP_596898.1

    Status: VALIDATED

    Source sequence(s)
    AA819812, AF312224, AI502900, CK474868, DV716943
    UniProtKB/Swiss-Prot
    Q924I2
    UniProtKB/TrEMBL
    A6H9Q1, R9PXT4
    Conserved Domains (3) summary
    smart00036
    Location:540 → 853
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:16 → 273
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    20029246..20198583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111726.2 → XP_038967654.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AV17
    Conserved Domains (2) summary
    smart00036
    Location:583 → 926
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  2. XM_039111728.2 → XP_038967656.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X4

    UniProtKB/TrEMBL
    R9PXT4
    Conserved Domains (2) summary
    smart00036
    Location:562 → 905
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  3. XM_039111729.2 → XP_038967657.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X6

    UniProtKB/TrEMBL
    A0A8I6AV17
    Conserved Domains (2) summary
    smart00036
    Location:583 → 896
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  4. XM_039111727.2 → XP_038967655.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AV17
    Conserved Domains (2) summary
    smart00036
    Location:572 → 915
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  5. XM_017594019.3 → XP_017449508.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AV17
    Conserved Domains (2) summary
    smart00036
    Location:572 → 915
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  6. XM_017594021.3 → XP_017449510.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform X7

    UniProtKB/TrEMBL
    R9PXT4
    Conserved Domains (2) summary
    smart00036
    Location:551 → 894
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  7. XM_017594020.3 → XP_017449509.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AV17
    Related
    ENSRNOP00000090754.2, ENSRNOT00000110847.2
    Conserved Domains (2) summary
    smart00036
    Location:561 → 904
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  8. XM_063261505.1 → XP_063117575.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X9

    Related
    ENSRNOP00000010366.8, ENSRNOT00000010366.9

  9. XM_063261504.1 → XP_063117574.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X8

    Related
    ENSRNOP00000069683.3, ENSRNOT00000084602.3

  10. XM_006239656.5 → XP_006239718.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform X10

    UniProtKB/TrEMBL
    A0A0G2JVZ8, A0A8I6AV17
    Related
    ENSRNOP00000097492.1, ENSRNOT00000118971.2
    Conserved Domains (2) summary
    smart00036
    Location:561 → 874
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  11. XM_039111730.2 → XP_038967658.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X11

    UniProtKB/TrEMBL
    R9PXT4
    Conserved Domains (2) summary
    smart00036
    Location:551 → 864
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  12. XM_039111731.2 → XP_038967659.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X12

    UniProtKB/TrEMBL
    A0A0G2JYP2
    Conserved Domains (2) summary
    smart00036
    Location:520 → 863
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:1 → 210
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  13. XM_039111732.1 → XP_038967660.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X14

    UniProtKB/TrEMBL
    A0A0G2JYP2
    Conserved Domains (2) summary
    smart00036
    Location:494 → 837
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:1 → 184
    PKc_like; Protein Kinases, catalytic domain

  14. XM_063261506.1 → XP_063117576.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X13

  15. XM_039111733.2 → XP_038967661.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X15

    UniProtKB/TrEMBL
    A0A0G2JYP2
    Conserved Domains (2) summary
    smart00036
    Location:406 → 749
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:1 → 96
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924I2.2 GenPept UniProtKB/Swiss-Prot:Q924I2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools