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Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 170905, updated on 2-Nov-2024

Summary

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Official Symbol
Lfngprovided by RGD
Official Full Name
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseprovided by RGD
Primary source
RGD:620587
See related
EnsemblRapid:ENSRNOG00000001250 AllianceGenome:RGD:620587
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in lymphocyte differentiation; negative regulation of Notch signaling pathway involved in somitogenesis; and somitogenesis. Predicted to act upstream of or within several processes, including compartment pattern specification; positive regulation of Notch signaling pathway; and regulation of somitogenesis. Predicted to be located in Golgi membrane. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 3. Orthologous to human LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 148.2), Lung (RPKM 128.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lfng in Genome Data Viewer
Location:
12q11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19144474..19152951, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (14030551..14038996, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16117767..16126211, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene BRCA1-associated ATM activator 1 Neighboring gene IQ motif containing E Neighboring gene tweety family member 3 Neighboring gene galectin-related inter-fiber protein Neighboring gene carbohydrate sulfotransferase 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutation of the fucose-specific beta1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine. Dunwoodie SL. Biochim Biophys Acta, 2009 Feb. PMID 19061953
  2. Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype. Sparrow DB, et al. Am J Hum Genet, 2006 Jan. PMID 16385447, Free PMC Article
  3. Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling. Okubo Y, et al. Nat Commun, 2012. PMID 23072809
  4. Fringe is a glycosyltransferase that modifies Notch. Moloney DJ, et al. Nature, 2000 Jul 27. PMID 10935626
  5. Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches. Tan JB, et al. Immunity, 2009 Feb 20. PMID 19217325

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.
    Title: Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in compartment pattern specification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within compartment pattern specification ISO
Inferred from Sequence Orthology
more info
  
involved_in marginal zone B cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in marginal zone B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in marginal zone B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of Notch signaling pathway involved in somitogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Notch signaling pathway involved in somitogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Notch signaling pathway involved in somitogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ovarian follicle development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ovarian follicle development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of somitogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of somitogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of somitogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in somitogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within somitogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in somitogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in somitogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Names
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
lunatic fringe gene homolog
NP_596884.1
XP_017453739.1
XP_063127094.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133393.2 → NP_596884.1  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe precursor

    See identical proteins and their annotated locations for NP_596884.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070933
    UniProtKB/Swiss-Prot
    Q924T4
    UniProtKB/TrEMBL
    A0A8L2UHG7, A6K1R9
    Related
    ENSRNOP00000086737.1, ENSRNOT00000101623.2
    Conserved Domains (1) summary
    pfam02434
    Location:109 → 357
    Fringe; Fringe-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    19144474..19152951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598250.3 → XP_017453739.1  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform X1

  2. XM_063271024.1 → XP_063127094.1  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924T4.1 GenPept UniProtKB/Swiss-Prot:Q924T4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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