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Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170847, updated on 2-Nov-2024

Summary

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Official Symbol
Kcnj15provided by RGD
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 15provided by RGD
Primary source
RGD:621662
See related
EnsemblRapid:ENSRNOG00000062944 AllianceGenome:RGD:621662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kir4.2
Summary
Enables inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Predicted to act upstream of or within potassium ion transmembrane transport. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Orthologous to human KCNJ15 (potassium inwardly rectifying channel subfamily J member 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 447.5) and Lung (RPKM 52.8) See more
Orthologs
human mouse all
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Genomic context

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See Kcnj15 in Genome Data Viewer
Location:
11q11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (48046953..48091285)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (34577397..34621725)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (35545185..35588517)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352313 Neighboring gene uncharacterized LOC120095565 Neighboring gene uncharacterized LOC102550135 Neighboring gene ETS transcription factor ERG Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC120095640

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Estradiol attenuates hypoxia-induced pulmonary endothelin-1 gene expression. Earley S, et al. Am J Physiol Lung Cell Mol Physiol, 2002 Jul. PMID 12060564
  2. Cloning, expression, and localization of a rat hepatocyte inwardly rectifying potassium channel. Hill CE, et al. Am J Physiol Gastrointest Liver Physiol, 2002 Feb. PMID 11804844
  3. Expression of a functional Kir4 family inward rectifier K+ channel from a gene cloned from mouse liver. Pearson WL, et al. J Physiol, 1999 Feb 1. PMID 9882736, Free PMC Article
  4. Inhibition of glucose-stimulated insulin secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes. Okamoto K, et al. Diabetes, 2012 Jul. PMID 22566534, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP-sensitive inward rectifier potassium channel 15
Names
inward rectifier K(+) channel Kir4.2
potassium channel, inwardly rectifying subfamily J member 15
potassium voltage-gated channel subfamily J member 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433865.1 → NP_001420794.1  ATP-sensitive inward rectifier potassium channel 15 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

  2. NM_001433866.1 → NP_001420795.1  ATP-sensitive inward rectifier potassium channel 15 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

  3. NM_001433867.1 → NP_001420796.1  ATP-sensitive inward rectifier potassium channel 15 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

  4. NM_001433868.1 → NP_001420797.1  ATP-sensitive inward rectifier potassium channel 15 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

  5. NM_001433869.1 → NP_001420798.1  ATP-sensitive inward rectifier potassium channel 15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

  6. NM_001433870.1 → NP_001420799.1  ATP-sensitive inward rectifier potassium channel 15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

  7. NM_001433871.1 → NP_001420800.1  ATP-sensitive inward rectifier potassium channel 15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

  8. NM_133321.3 → NP_579855.1  ATP-sensitive inward rectifier potassium channel 15 isoform 1

    See identical proteins and their annotated locations for NP_579855.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    Q91ZF1
    UniProtKB/TrEMBL
    A0A8L2PZJ4, A6KPU9
    Conserved Domains (1) summary
    pfam01007
    Location:60 → 386
    IRK; Inward rectifier potassium channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    48046953..48091285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248128.5 → XP_006248190.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    See identical proteins and their annotated locations for XP_006248190.1

    UniProtKB/Swiss-Prot
    Q91ZF1
    UniProtKB/TrEMBL
    A0A8L2PZJ4, A6KPU9
    Conserved Domains (1) summary
    pfam01007
    Location:60 → 386
    IRK; Inward rectifier potassium channel

  2. XM_006248131.5 → XP_006248193.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    UniProtKB/Swiss-Prot
    Q91ZF1
    UniProtKB/TrEMBL
    A0A8L2PZJ4, A6KPU9
    Conserved Domains (1) summary
    pfam01007
    Location:60 → 386
    IRK; Inward rectifier potassium channel

  3. XM_039087927.2 → XP_038943855.1  ATP-sensitive inward rectifier potassium channel 15 isoform X3

    UniProtKB/TrEMBL
    A0A8L2PZJ4
    Conserved Domains (2) summary
    pfam01007
    Location:49 → 190
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:197 → 368
    IRK_C; Inward rectifier potassium channel C-terminal domain

  4. XM_063270252.1 → XP_063126322.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    UniProtKB/Swiss-Prot
    Q91ZF1
    UniProtKB/TrEMBL
    A6KPU9

  5. XM_008768550.4 → XP_008766772.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    See identical proteins and their annotated locations for XP_008766772.1

    UniProtKB/Swiss-Prot
    Q91ZF1
    UniProtKB/TrEMBL
    A0A8L2PZJ4, A6KPU9
    Conserved Domains (1) summary
    pfam01007
    Location:60 → 386
    IRK; Inward rectifier potassium channel

  6. XM_006248129.5 → XP_006248191.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    UniProtKB/Swiss-Prot
    Q91ZF1
    UniProtKB/TrEMBL
    A0A8L2PZJ4, A6KPU9
    Conserved Domains (1) summary
    pfam01007
    Location:60 → 386
    IRK; Inward rectifier potassium channel

  7. XM_006248132.5 → XP_006248194.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    See identical proteins and their annotated locations for XP_006248194.1

    UniProtKB/Swiss-Prot
    Q91ZF1
    UniProtKB/TrEMBL
    A0A8L2PZJ4, A6KPU9
    Conserved Domains (1) summary
    pfam01007
    Location:60 → 386
    IRK; Inward rectifier potassium channel

  8. XM_008768552.4 → XP_008766774.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    See identical proteins and their annotated locations for XP_008766774.1

    UniProtKB/Swiss-Prot
    Q91ZF1
    UniProtKB/TrEMBL
    A0A8L2PZJ4, A6KPU9
    Conserved Domains (1) summary
    pfam01007
    Location:60 → 386
    IRK; Inward rectifier potassium channel

  9. XM_006248133.5 → XP_006248195.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    UniProtKB/Swiss-Prot
    Q91ZF1
    UniProtKB/TrEMBL
    A0A8L2PZJ4, A6KPU9
    Conserved Domains (1) summary
    pfam01007
    Location:60 → 386
    IRK; Inward rectifier potassium channel

  10. XM_039087926.2 → XP_038943854.1  ATP-sensitive inward rectifier potassium channel 15 isoform X2

    UniProtKB/TrEMBL
    A0A8L2PZJ4
    Related
    ENSRNOP00000078466.1, ENSRNOT00000108557.2
    Conserved Domains (2) summary
    pfam01007
    Location:30 → 171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

  11. XM_006248139.5 → XP_006248201.1  ATP-sensitive inward rectifier potassium channel 15 isoform X2

    UniProtKB/TrEMBL
    A0A8L2PZJ4
    Related
    ENSRNOP00000089124.1, ENSRNOT00000104151.2
    Conserved Domains (2) summary
    pfam01007
    Location:30 → 171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

  12. XM_039087925.2 → XP_038943853.1  ATP-sensitive inward rectifier potassium channel 15 isoform X2

    UniProtKB/TrEMBL
    A0A8L2PZJ4
    Related
    ENSRNOP00000093558.1, ENSRNOT00000111664.2
    Conserved Domains (2) summary
    pfam01007
    Location:30 → 171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

  13. XM_006248135.4 → XP_006248197.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    UniProtKB/Swiss-Prot
    Q91ZF1
    UniProtKB/TrEMBL
    A0A8L2PZJ4, A6KPU9
    Conserved Domains (1) summary
    pfam01007
    Location:60 → 386
    IRK; Inward rectifier potassium channel

  14. XM_039087924.2 → XP_038943852.1  ATP-sensitive inward rectifier potassium channel 15 isoform X2

    UniProtKB/TrEMBL
    A0A8L2PZJ4
    Related
    ENSRNOP00000098859.1, ENSRNOT00000165093.1
    Conserved Domains (2) summary
    pfam01007
    Location:30 → 171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

  15. XM_006248141.5 → XP_006248203.1  ATP-sensitive inward rectifier potassium channel 15 isoform X2

    See identical proteins and their annotated locations for XP_006248203.1

    UniProtKB/TrEMBL
    A0A8L2PZJ4
    Related
    ENSRNOP00000091174.1, ENSRNOT00000099760.2
    Conserved Domains (2) summary
    pfam01007
    Location:30 → 171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZF1.1 GenPept UniProtKB/Swiss-Prot:Q91ZF1

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