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Mutyh mutY DNA glycosylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 170841, updated on 2-Nov-2024

Summary

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Official Symbol
Mutyhprovided by RGD
Official Full Name
mutY DNA glycosylaseprovided by RGD
Primary source
RGD:620045
See related
EnsemblRapid:ENSRNOG00000017887 AllianceGenome:RGD:620045
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Myh
Summary
Enables DNA N-glycosylase activity. Involved in response to oxidative stress. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in familial adenomatous polyposis; familial adenomatous polyposis 2; stomach cancer; and stomach carcinoma. Orthologous to human MUTYH (mutY DNA glycosylase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 94.0), Spleen (RPKM 54.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mutyh in Genome Data Viewer
Location:
5q35
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135510666..135522777)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (130274034..130286149)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135663328..135675348)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene metabolism of cobalamin associated C Neighboring gene coiled-coil domain containing 163 Neighboring gene testis associated actin remodelling kinase 2 Neighboring gene ribosomal protein S26 like 4 Neighboring gene target of EGR1, exonuclease Neighboring gene 4-hydroxyphenylpyruvate dioxygenase-like Neighboring gene ribosomal protein S20, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Developmental changes in expression and subcellular localization of the DNA repair glycosylase, MYH, in the rat brain. Lee HM, et al. J Neurochem, 2004 Jan. PMID 14690527
  2. Rat MYH, a glycosylase for repair of oxidatively damaged DNA, has brain-specific isoforms that localize to neuronal mitochondria. Englander EW, et al. J Neurochem, 2002 Dec. PMID 12472901
  3. MutY DNA Glycosylase Protects Cells From Tumor Necrosis Factor Alpha-Induced Necroptosis. Tran AHV, et al. J Cell Biochem, 2017 Jul. PMID 28059467
  4. Adenine DNA glycosylase activity of 14 human MutY homolog (MUTYH) variant proteins found in patients with colorectal polyposis and cancer. Goto M, et al. Hum Mutat, 2010 Nov. PMID 20848659, Free PMC Article
  5. Genetic alterations of the MYH gene in gastric cancer. Kim CJ, et al. Oncogene, 2004 Sep 2. PMID 15273732

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. respiratory hypoxia leads to increased expression of MYH in the rat brain
    Title: Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase homolog (MYH), in vivo, in the rat brain.
  2. Levels of MutY DNA glycosylase are detected in rat brain at the embryonic stage, decrease during embryonic and neonatal development, while new isoforms appear and gradually increase in the neonate and adult brain.
    Title: Developmental changes in expression and subcellular localization of the DNA repair glycosylase, MYH, in the rat brain.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC156598

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables MutLalpha complex binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables MutLbeta complex binding ISO
Inferred from Sequence Orthology
more info
  
enables MutSalpha complex binding IEA
Inferred from Electronic Annotation
more info
  
enables MutSalpha complex binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables MutSbeta complex binding ISO
Inferred from Sequence Orthology
more info
  
enables adenine/guanine mispair binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidized purine DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables purine-specific mismatch base pair DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables purine-specific mismatch base pair DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables purine-specific mismatch base pair DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
  
enables purine-specific mismatch base pair DNA N-glycosylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in base-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of necroptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adenine DNA glycosylase
Names
a/G-specific adenine DNA glycosylase
mutY homolog
rMYH
NP_579850.2
XP_038965128.1
XP_038965129.1
XP_038965130.1
XP_038965131.1
XP_038965132.1
XP_038965133.1
XP_038965135.1
XP_038965136.1
XP_063143179.1
XP_063143180.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133316.2 → NP_579850.2  adenine DNA glycosylase

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q8R5G2
    UniProtKB/TrEMBL
    A6JZA6, G3V8C1
    Related
    ENSRNOP00000083752.1, ENSRNOT00000118511.2
    Conserved Domains (1) summary
    COG1194
    Location:63 → 463
    MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    135510666..135522777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109200.2 → XP_038965128.1  adenine DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    Q8R5G2
    Conserved Domains (1) summary
    COG1194
    Location:63 → 470
    MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

  2. XM_039109202.2 → XP_038965130.1  adenine DNA glycosylase isoform X2

    UniProtKB/Swiss-Prot
    Q8R5G2
    Conserved Domains (1) summary
    COG1194
    Location:63 → 432
    MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

  3. XM_063287109.1 → XP_063143179.1  adenine DNA glycosylase isoform X3

  4. XM_039109208.2 → XP_038965136.1  adenine DNA glycosylase isoform X8

    Conserved Domains (1) summary
    COG1194
    Location:63 → 282
    MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

  5. XM_039109207.2 → XP_038965135.1  adenine DNA glycosylase isoform X7

    Conserved Domains (1) summary
    COG1194
    Location:63 → 293
    MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

  6. XM_039109201.2 → XP_038965129.1  adenine DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    Q8R5G2
    Conserved Domains (1) summary
    COG1194
    Location:63 → 470
    MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

  7. XM_039109203.2 → XP_038965131.1  adenine DNA glycosylase isoform X4

    Conserved Domains (1) summary
    COG1194
    Location:1 → 364
    MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

  8. XM_039109204.2 → XP_038965132.1  adenine DNA glycosylase isoform X5

    Conserved Domains (1) summary
    COG1194
    Location:1 → 347
    MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

  9. XM_063287110.1 → XP_063143180.1  adenine DNA glycosylase isoform X6

  10. XM_039109205.2 → XP_038965133.1  adenine DNA glycosylase isoform X5

    Conserved Domains (1) summary
    COG1194
    Location:1 → 347
    MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

RNA

  1. XR_010066340.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R5G2.1 GenPept UniProtKB/Swiss-Prot:Q8R5G2

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