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Capn8 calpain 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170808, updated on 28-Oct-2024

Summary

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Official Symbol
Capn8provided by RGD
Official Full Name
calpain 8provided by RGD
Primary source
RGD:620085
See related
EnsemblRapid:ENSRNOG00000003468 AllianceGenome:RGD:620085
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cls4; CL-2'; nCL-2
Summary
Predicted to enable calcium-dependent cysteine-type endopeptidase activity and identical protein binding activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within calcium-dependent self proteolysis. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Orthologous to human CAPN8 (calpain 8). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Adrenal (RPKM 29.3), Spleen (RPKM 4.5) and 2 other tissues See more
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Genomic context

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See Capn8 in Genome Data Viewer
Location:
13q26
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (96783640..96847825)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (94252218..94316146)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (100980149..101043110)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096330 Neighboring gene uncharacterized LOC120096331 Neighboring gene coiled-coil domain containing 185 Neighboring gene sushi domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Estrogen regulates a tissue-specific calpain in the anterior pituitary. Duan WR, et al. Biochem Biophys Res Commun, 2002 Jul 12. PMID 12150941
  2. A novel tissue-specific calpain species expressed predominantly in the stomach comprises two alternative splicing products with and without Ca(2+)-binding domain. Sorimachi H, et al. J Biol Chem, 1993 Sep 15. PMID 7690035
  3. Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP. Hata S, et al. J Biol Chem, 2006 Apr 21. PMID 16476741
  4. Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains. Hata S, et al. J Biol Chem, 2007 Sep 21. PMID 17646163
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP
    Title: Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium-dependent self proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
calpain-8
Names
calpain large subunit 4
cysteine protease
new calpain 2
novel Calpain Large subunit
stomach-specific M-type calpain
tissue-specific calpain 2
NP_579843.2
XP_006250425.2
XP_063128049.1
XP_063128050.1
XP_063128051.1
XP_063128052.1
XP_063128053.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133309.2 → NP_579843.2  calpain-8

    See identical proteins and their annotated locations for NP_579843.2

    Status: PROVISIONAL

    Source sequence(s)
    D14479
    UniProtKB/Swiss-Prot
    Q64698, Q78EJ8, Q78EJ9, Q8K407
    UniProtKB/TrEMBL
    A6JGM1
    Related
    ENSRNOP00000062898.4, ENSRNOT00000067005.6
    Conserved Domains (4) summary
    PTZ00183
    Location:612 → 692
    PTZ00183; centrin; Provisional
    cd00051
    Location:580 → 635
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:46 → 342
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:356 → 509
    Calpain_III; Calpain large subunit, domain III

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    96783640..96847825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271983.1 → XP_063128053.1  calpain-8 isoform X6

  2. XM_063271979.1 → XP_063128049.1  calpain-8 isoform X1

  3. XM_063271982.1 → XP_063128052.1  calpain-8 isoform X4

  4. XM_063271981.1 → XP_063128051.1  calpain-8 isoform X3

  5. XM_006250363.5 → XP_006250425.2  calpain-8 isoform X5

    UniProtKB/TrEMBL
    A6JGM3
    Related
    ENSRNOP00000004649.6, ENSRNOT00000004649.8
    Conserved Domains (2) summary
    pfam00648
    Location:96 → 392
    Peptidase_C2; Calpain family cysteine protease
    cl00165
    Location:406 → 430
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...

  6. XM_063271980.1 → XP_063128050.1  calpain-8 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q78EJ9.1 GenPept UniProtKB/Swiss-Prot:Q78EJ9

Gene LinkOut

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