Nherf4 NHERF family PDZ scaffold protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nherf4provided by MGI
Official Full Name: NHERF family PDZ scaffold protein 4provided by MGI
Primary source: MGI:MGI:2429554
See related: Ensembl:ENSMUSG00000032105 AllianceGenome:MGI:2429554
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pdzd3; Pdzk2; NaPi-Cap2
Summary: Predicted to enable several functions, including guanylate cyclase inhibitor activity; protein C-terminus binding activity; and ubiquitin-specific protease binding activity. Predicted to be involved in negative regulation of cGMP-mediated signaling and protein localization to plasma membrane. Located in several cellular components, including apical part of cell; brush border; and cytoplasm. Orthologous to human PDZD3 (PDZ domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 25.1), large intestine adult (RPKM 16.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (44158609..44162761, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (44247312..44251464, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of NHE3 depends on the nature of the NHERF family member associating with NHE3 and the accompanying NHE3 complexes.[IKEPP]
Title: Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.
PDZK2 is an essential TRPV6 interacting protein as a physiological modulator of TRPV6.
Title: PDZ domain-containing protein as a physiological modulator of TRPV6.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanylate cyclase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-specific protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical junction complex	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Na(+)/H(+) exchange regulatory cofactor NHE-RF4

Names: NHERF-4; PDZ domain containing 2; PDZ domain containing 3; PDZ domain-containing protein 2; PDZ domain-containing protein 3; na/Pi cotransporter C-terminal-associated protein 2; natrium-phosphate cotransporter IIa C-terminal-associated protein 2; sodium-hydrogen exchanger regulatory factor 4; sodium-phosphate cotransporter IIa C-terminal-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133226.2 → NP_573489.2 Na(+)/H(+) exchange regulatory cofactor NHE-RF4

See identical proteins and their annotated locations for NP_573489.2

Status: VALIDATED

Source sequence(s)

AK052748, BY368735

Consensus CDS

CCDS23099.1

UniProtKB/Swiss-Prot

Q8BWE5, Q99MJ6

UniProtKB/TrEMBL

A0A0R4J0D4

Related

ENSMUSP00000034618.5, ENSMUST00000034618.6

Conserved Domains (2) summary

smart00228
Location:260 → 345

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:47 → 127

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...