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Xpnpep2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound [ Mus musculus (house mouse) ]

Gene ID: 170745, updated on 2-Nov-2024

Summary

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Official Symbol
Xpnpep2provided by MGI
Official Full Name
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-boundprovided by MGI
Primary source
MGI:MGI:2180001
See related
Ensembl:ENSMUSG00000037005 AllianceGenome:MGI:2180001
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mAPP; 9030008G12Rik
Summary
Predicted to enable metal ion binding activity and metalloaminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular exosome. Is expressed in brain; forelimb bud; large intestine; and neural retina. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to human XPNPEP2 (X-prolyl aminopeptidase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 66.4), small intestine adult (RPKM 32.1) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Xpnpep2 in Genome Data Viewer
Location:
X A4; X 25.52 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (47195790..47225859)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (48106913..48136982)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene calmodulin 2 pseudogene Neighboring gene apelin Neighboring gene STARR-seq mESC enhancer starr_47100 Neighboring gene STARR-seq mESC enhancer starr_47102 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:45490128-45490351 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:45494812-45494921 Neighboring gene SAM and SH3 domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_47106 Neighboring gene zinc finger, DHHC domain containing 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rat and mouse membrane aminopeptidase P: structure analysis and tissue distribution. Erşahin C, et al. Arch Biochem Biophys, 2003 Sep 15. PMID 12941294
  2. Wnt signaling specifies and patterns intestinal endoderm. Sherwood RI, et al. Mech Dev, 2011 Sep-Dec. PMID 21854845, Free PMC Article
  3. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
  4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
  5. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
xaa-Pro aminopeptidase 2
Names
X-prolyl aminopeptidase 2
membrane-bound APP
membrane-bound aminopeptidase P
NP_001276658.1
NP_573476.2
XP_006541495.1
XP_036017721.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289729.1 → NP_001276658.1  xaa-Pro aminopeptidase 2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AF428102, AK078835, AK085520, AK164538, AL672274
    Consensus CDS
    CCDS81125.1
    UniProtKB/TrEMBL
    B1AVD2
    Related
    ENSMUSP00000110652.4, ENSMUST00000115000.4
    Conserved Domains (5) summary
    COG0006
    Location:367 → 656
    PepP; Xaa-Pro aminopeptidase [Amino acid transport and metabolism]
    cd01085
    Location:432 → 651
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam01321
    Location:53 → 177
    Creatinase_N; Creatinase/Prolidase N-terminal domain
    pfam16188
    Location:651 → 715
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:202 → 428
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain

  2. NM_133213.2 → NP_573476.2  xaa-Pro aminopeptidase 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_573476.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate splice site in the 3' coding region, compared to variant 2. This results in a shorter protein (isoform 1), compared to isoform 2.
    Source sequence(s)
    AF428102, AK164538, AL672274
    Consensus CDS
    CCDS30106.1
    UniProtKB/Swiss-Prot
    B1AVD1, Q3TA51, Q3TPA9, Q8BVD6, Q91Y31, Q91ZH9
    Related
    ENSMUSP00000076951.5, ENSMUST00000077775.11
    Conserved Domains (4) summary
    cd01085
    Location:365 → 584
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam01321
    Location:54 → 177
    Creatinase_N; Creatinase/Prolidase N-terminal domain
    pfam16188
    Location:584 → 648
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:195 → 361
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    47195790..47225859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541432.1 → XP_006541495.1  xaa-Pro aminopeptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_006541495.1

    UniProtKB/Swiss-Prot
    B1AVD1, Q3TA51, Q3TPA9, Q8BVD6, Q91Y31, Q91ZH9
    Conserved Domains (4) summary
    cd01085
    Location:365 → 584
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam01321
    Location:54 → 177
    Creatinase_N; Creatinase/Prolidase N-terminal domain
    pfam16188
    Location:584 → 648
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:195 → 361
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain

  2. XM_036161828.1 → XP_036017721.1  xaa-Pro aminopeptidase 2 isoform X2

    UniProtKB/TrEMBL
    Q8BU59
    Related
    ENSMUSP00000110650.2, ENSMUST00000114998.8
    Conserved Domains (3) summary
    cd01085
    Location:365 → 582
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam01321
    Location:54 → 177
    Creatinase_N; Creatinase/Prolidase N-terminal domain
    pfam16189
    Location:195 → 361
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AVD1.1 GenPept UniProtKB/Swiss-Prot:B1AVD1

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