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XAGE5 X antigen family member 5 [ Homo sapiens (human) ]

Gene ID: 170627, updated on 5-Mar-2024

Summary

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Official Symbol
XAGE5provided by HGNC
Official Full Name
X antigen family member 5provided by HGNC
Primary source
HGNC:HGNC:30930
See related
Ensembl:ENSG00000171405 MIM:301063; AllianceGenome:HGNC:30930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT12.5; GAGED5; XAGE-5
Summary
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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Location:
Xp11.22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (52811287..52818301)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (52096193..52103207)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (52840311..52847325)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SSX family member 21, pseudogene Neighboring gene SPANX family member N5 Neighboring gene X antigen family member 3-like Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:52855217-52856182 Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. Zendman AJ, et al. Int J Cancer, 2002 May 20. PMID 11992404
  2. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Clone Names

  • MGC119799, MGC119800

General protein information

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Preferred Names
X antigen family member 5
Names
G antigen, family D, 5
cancer/testis antigen 12.5
cancer/testis antigen family 12, member 5
g antigen family D member 5
protein XAGE-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386970.1 → NP_001373899.1  X antigen family member 5

    Status: VALIDATED

    Source sequence(s)
    AC244505
    Consensus CDS
    CCDS14346.1
    UniProtKB/Swiss-Prot
    Q5JS81, Q8WWM1
    Related
    ENSP00000364651.1, ENST00000375501.2
    Conserved Domains (1) summary
    pfam05831
    Location:17 → 102
    GAGE; GAGE protein

  2. NM_130775.3 → NP_570131.1  X antigen family member 5

    See identical proteins and their annotated locations for NP_570131.1

    Status: VALIDATED

    Source sequence(s)
    AC244505
    Consensus CDS
    CCDS14346.1
    UniProtKB/Swiss-Prot
    Q5JS81, Q8WWM1
    Conserved Domains (1) summary
    pfam05831
    Location:17 → 102
    GAGE; GAGE protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    52811287..52818301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    52096193..52103207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WWM1.1 GenPept UniProtKB/Swiss-Prot:Q8WWM1

Gene LinkOut

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