Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp3a62provided by RGD
Official Full Name: cytochrome P450, family 3, subfamily a, polypeptide 62provided by RGD
Primary source: RGD:1595919
See related: EnsemblRapid:ENSRNOG00000001379 AllianceGenome:RGD:1595919
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CYP3; Cyp3a
Summary: Predicted to enable testosterone 6-beta-hydroxylase activity. Predicted to be involved in oxidative demethylation and steroid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough) and CYP3A7 (cytochrome P450 family 3 subfamily A member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 42.8), Brain (RPKM 13.3) and 2 other tissues See more
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Genomic context

Location:: 12q11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (21511763..21547598)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (16397998..16433833)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (18679809..18709397)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential expression and activities of cytochrome P450 3A in the rat brain microsomes and mitochondria.
Title: Differential expression and activities of cytochrome P450 3A in the rat brain microsomes and mitochondria.
This study suggests that there is an impairment of CYP2D and CYP3A metabolism in aging rats.
Title: In vitro metabolism of specific CYP2D and CYP3A opioid substrates using rat liver S9 fractions and mass spectrometry reveal a severe metabolic impairment with increasing age.
The aim of the current work was to study the effect of dexamethasone (DEX) on the gene expression and function of CYP3A23 (in rat), CYP3A28 (in cattle) and the transcriptional factors involved in their regulation.
Title: Gene expression and enzyme function of two cytochrome P450 3A isoenzymes in rat and cattle precision cut liver slices.
mRNA and protein expression of CYP3A were significantly induced and the absorbance and bioavailability of midazolam in rats were reduced
Title: Induction of CYP3A by morroniside in rats.
CYP3A mRNA expressions in goat and rat gastrointestinal tracts in comparison to the liver were investigated using real-time PCR.
Title: Cytochrome P450 3A mRNA expression along goat and rat gastrointestinal tracts.
Report a lack of potent drug-drug interactions between both Kampo extract medicines and CYP3A substrate drugs.
Title: Effects of furanocoumarins in Kampo extract-based medicines on rat intestinal absorption of CYP3A and P-glycoprotein substrate drugs in vivo.
Aqueous extract of Schisandra chinensis could show a dual effect on the enzyme activity of CYP3A in rat in vivo.
Title: [Dual effects of extract of Schisandra chinensis Baill on rat hepatic CYP3A].
Danshen extract affected the metabolism of CYP3A substrates through competitive inhibition in human and rat liver in vitro and had no enzyme inducing effects on rat CYP3A in vivo after chronic administration.
Title: Effects of Salvia miltiorrhiza extract on the liver CYP3A activity in humans and rats.
the poor bioavailability of buagafuran was mostly due to the interplay of P-gp and CYP3A on the absorption, transport and metabolism of buagafuran in intestine
Title: [Effect of CYP3A and P-glycoprotein on the absorption of buagafuran in rat intestinal lumen].
A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16alpha-carbonitrile.
Title: A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrile.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF400282 (e-PCR)
- UniSTS:244911

AW529990 (e-PCR)
- UniSTS:261375

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables testosterone 6-beta-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in oxidative demethylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450, family 3, subfamily a, polypeptide 62

Names: cytochrome P450, subfamily 3A, polypeptide 62; cytochrome P450, subfamily IIA (niphedipine oxidase); cytochrome P450, subfamily IIIA (niphedipine oxidase)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.