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TMEM273 transmembrane protein 273 [ Homo sapiens (human) ]

Gene ID: 170371, updated on 5-Mar-2024

Summary

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Official Symbol
TMEM273provided by HGNC
Official Full Name
transmembrane protein 273provided by HGNC
Primary source
HGNC:HGNC:27274
See related
Ensembl:ENSG00000204161 AllianceGenome:HGNC:27274
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C10orf128
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 4.4), spleen (RPKM 4.0) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
10q11.23
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (49154736..49188391, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (50003603..50037281, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (50362781..50396436, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902545 Neighboring gene FAM170B antisense RNA 1 Neighboring gene family with sequence similarity 170 member B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50378847-50379346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50382921-50383422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50383423-50383922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3349 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:50451046-50451717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50462512-50463040 Neighboring gene C10orf71 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:50505091-50505268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2361 Neighboring gene chromosome 10 open reading frame 71 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:50543527-50544726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50587592-50588092 Neighboring gene dorsal root ganglia homeobox

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107410
  2. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ52649

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 273

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010863.4 → NP_001010863.1  transmembrane protein 273 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001010863.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC031641, BC047724, BC104438, CA396219
    Consensus CDS
    CCDS41519.1
    UniProtKB/Swiss-Prot
    A6XND2, Q5T289, Q5T291, Q5T292
    Related
    ENSP00000417246.1, ENST00000474718.6
    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

  2. NM_001288740.3 → NP_001275669.1  transmembrane protein 273 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001275669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus.
    Source sequence(s)
    AL524299, BC031641, BC047724, CA396219
    Consensus CDS
    CCDS73128.1
    UniProtKB/TrEMBL
    A0A0A0MRR9
    Related
    ENSP00000363268.1, ENST00000374153.7
    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

  3. NM_001288741.3 → NP_001275670.1  transmembrane protein 273 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC031641, BC047724, CA396219, DA366138
    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

  4. NM_001288742.3 → NP_001275671.1  transmembrane protein 273 isoform 4

    See identical proteins and their annotated locations for NP_001275671.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the central coding region, which results in a frameshift, and uses an alternate splice site in the 3'-terminal exon, compared to variant 1. The encoded isoform (4) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC031641, BC047724, BU145920, CA396219
    UniProtKB/TrEMBL
    Q5T290
    Related
    ENSP00000395067.1, ENST00000453436.5
    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

  5. NM_001288743.3 → NP_001275672.1  transmembrane protein 273 isoform 5

    See identical proteins and their annotated locations for NP_001275672.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) includes an alternate exon in the central coding region, which results in a frameshift, and uses an alternate splice site in the 3'-terminal exon, compared to variant 1. The encoded isoform (5) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC031641, BC047724, BU145920, CA396219, DQ884399
    UniProtKB/TrEMBL
    A0A0A0MRR9
    Related
    ENSP00000363266.4, ENST00000374151.7
    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

  6. NM_001353330.2 → NP_001340259.1  transmembrane protein 273 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC084727, AL441885
    UniProtKB/TrEMBL
    A0AA34QVZ6
    Related
    ENSP00000516763.1, ENST00000707141.1
    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

  7. NM_001353331.2 → NP_001340260.1  transmembrane protein 273 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084727, AL441885
    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    49154736..49188391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015797.2 → XP_016871286.1  transmembrane protein 273 isoform X10

    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

  2. XM_011539385.2 → XP_011537687.1  transmembrane protein 273 isoform X15

    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

  3. XM_017015794.2 → XP_016871283.1  transmembrane protein 273 isoform X8

    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

  4. XM_011539384.2 → XP_011537686.1  transmembrane protein 273 isoform X14

    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

  5. XM_047424684.1 → XP_047280640.1  transmembrane protein 273 isoform X4

  6. XM_047424687.1 → XP_047280643.1  transmembrane protein 273 isoform X7

  7. XM_047424685.1 → XP_047280641.1  transmembrane protein 273 isoform X13

  8. XM_017015793.2 → XP_016871282.1  transmembrane protein 273 isoform X3

    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

  9. XM_017015792.2 → XP_016871281.1  transmembrane protein 273 isoform X1

    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

  10. XM_011539379.2 → XP_011537681.1  transmembrane protein 273 isoform X12

    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

  11. XM_024447853.2 → XP_024303621.1  transmembrane protein 273 isoform X11

    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

  12. XM_011539382.2 → XP_011537684.1  transmembrane protein 273 isoform X5

    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

  13. XM_047424686.1 → XP_047280642.1  transmembrane protein 273 isoform X6

  14. XM_011539378.3 → XP_011537680.1  transmembrane protein 273 isoform X2

    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

  15. XM_017015796.2 → XP_016871285.1  transmembrane protein 273 isoform X9

    Conserved Domains (1) summary
    pfam14986
    Location:15 → 74
    DUF4514; Domain of unknown function (DUF4514)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    50003603..50037281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364936.1 → XP_054220911.1  transmembrane protein 273 isoform X10

  2. XM_054364934.1 → XP_054220909.1  transmembrane protein 273 isoform X8

  3. XM_054364930.1 → XP_054220905.1  transmembrane protein 273 isoform X4

  4. XM_054364933.1 → XP_054220908.1  transmembrane protein 273 isoform X7

  5. XM_054364929.1 → XP_054220904.1  transmembrane protein 273 isoform X3

  6. XM_054364927.1 → XP_054220902.1  transmembrane protein 273 isoform X1

  7. XM_054364937.1 → XP_054220912.1  transmembrane protein 273 isoform X11

  8. XM_054364931.1 → XP_054220906.1  transmembrane protein 273 isoform X5

  9. XM_054364932.1 → XP_054220907.1  transmembrane protein 273 isoform X6

  10. XM_054364928.1 → XP_054220903.1  transmembrane protein 273 isoform X2

  11. XM_054364935.1 → XP_054220910.1  transmembrane protein 273 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T292.1 GenPept UniProtKB/Swiss-Prot:Q5T292

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