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IDO2 indoleamine 2,3-dioxygenase 2 [ Homo sapiens (human) ]

Gene ID: 169355, updated on 7-Apr-2024

Summary

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Official Symbol
IDO2provided by HGNC
Official Full Name
indoleamine 2,3-dioxygenase 2provided by HGNC
Primary source
HGNC:HGNC:27269
See related
Ensembl:ENSG00000188676 MIM:612129; AllianceGenome:HGNC:27269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INDOL1
Summary
Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]
Expression
Biased expression in placenta (RPKM 9.5), liver (RPKM 2.8) and 3 other tissues See more
Orthologs
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Genomic context

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Location:
8p11.21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (39934651..40016392)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (40211488..40293321)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (39792170..39873911)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7a pseudogene 80 Neighboring gene Sharpr-MPRA regulatory region 12355 Neighboring gene polo like kinase 4 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:39807747-39808491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27279 Neighboring gene indoleamine 2,3-dioxygenase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:39835255-39836184 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:39836330-39836562 Neighboring gene Sharpr-MPRA regulatory region 1248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27280 Neighboring gene nuclear transcription factor Y subunit beta pseudogene Neighboring gene Sharpr-MPRA regulatory region 3146 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:39908434-39908606 Neighboring gene HNF4 motif-containing MPRA enhancer 150 Neighboring gene uncharacterized LOC105379385 Neighboring gene HNF1 motif-containing MPRA enhancer 269 Neighboring gene transcriptional and immune response regulator Neighboring gene NANOG hESC enhancer GRCh37_chr8:40077338-40077937 Neighboring gene NANOG hESC enhancer GRCh37_chr8:40194220-40194743 Neighboring gene SIRT1 regulating lncRNA tumor promoter

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Indoleamine 2,3-dioxygenase 2 immunohistochemical expression in medullary thyroid carcinoma: implications in prognosis and immunomodulatory effects. Gu P, et al. BMC Cancer, 2022 Nov 1. PMID 36319978, Free PMC Article
  2. Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19. de Lima Beltrão FE, et al. J Clin Endocrinol Metab, 2022 May 17. PMID 35137147, Free PMC Article
  3. IDO2 rs10109853 polymorphism affects the susceptibility to multiple myeloma. Kasamatsu T, et al. Clin Exp Med, 2021 May. PMID 33709342
  4. Indoleamine 2,3-Dioxygenase 2 Immunohistochemical Expression in Resected Human Non-small Cell Lung Cancer: A Potential New Prognostic Tool. Mandarano M, et al. Front Immunol, 2020. PMID 32536910, Free PMC Article
  5. Host IDO2 Gene Status Influences Tumor Progression and Radiotherapy Response in KRAS-Driven Sporadic Pancreatic Cancers. Nevler A, et al. Clin Cancer Res, 2019 Jan 15. PMID 30266763, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Marked IDO2 expression and activity related to autophagy and apoptosis in brain tissue of fatal tuberculous meningitis.
    Title: Marked IDO2 expression and activity related to autophagy and apoptosis in brain tissue of fatal tuberculous meningitis.
  2. Membrane Localization and Phosphorylation of Indoleamine 2,3-Dioxygenase 2 (IDO2) in A549 Human Lung Adenocarcinoma Cells: First Steps in Exploring Its Signaling Function.
    Title: Membrane Localization and Phosphorylation of Indoleamine 2,3-Dioxygenase 2 (IDO2) in A549 Human Lung Adenocarcinoma Cells: First Steps in Exploring Its Signaling Function.
  3. Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection.
    Title: Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection.
  4. Regulation of IDO2 by the Aryl Hydrocarbon Receptor (AhR) in Breast Cancer.
    Title: Regulation of IDO2 by the Aryl Hydrocarbon Receptor (AhR) in Breast Cancer.
  5. Indoleamine 2,3-dioxygenase 2 immunohistochemical expression in medullary thyroid carcinoma: implications in prognosis and immunomodulatory effects.
    Title: Indoleamine 2,3-dioxygenase 2 immunohistochemical expression in medullary thyroid carcinoma: implications in prognosis and immunomodulatory effects.
  6. Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19.
    Title: Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19.
  7. Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19.
    Title: Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19.
  8. Single-nucleotide polymorphisms and activities of indoleamine 2,3-dioxygenase isoforms, IDO1 and IDO2, in tuberculosis patients.
    Title: Single-nucleotide polymorphisms and activities of indoleamine 2,3-dioxygenase isoforms, IDO1 and IDO2, in tuberculosis patients.
  9. IDO2 rs10109853 polymorphism affects the susceptibility to multiple myeloma.
    Title: IDO2 rs10109853 polymorphism affects the susceptibility to multiple myeloma.
  10. Investigating the Role of Indoleamine 2,3-Dioxygenase in Acute Myeloid Leukemia: A Systematic Review.
    Title: Investigating the Role of Indoleamine 2,3-Dioxygenase in Acute Myeloid Leukemia: A Systematic Review.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables indoleamine 2,3-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables indoleamine 2,3-dioxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables indoleamine 2,3-dioxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tryptophan 2,3-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan catabolic process to kynurenine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tryptophan catabolic process to kynurenine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tryptophan catabolic process to kynurenine IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan catabolic process to kynurenine ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
indoleamine 2,3-dioxygenase 2
Names
indoleamine 2,3-dioxygenase-like 1 protein
indoleamine 2,3-dioxygenase-like protein 1
indoleamine-pyrrole 2,3 dioxygenase-like 1
indoleamine-pyrrole 2,3-dioxygenase-like protein 1
NP_001382135.1
NP_919270.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395206.1 → NP_001382135.1  indoleamine 2,3-dioxygenase 2

    Status: VALIDATED

    Source sequence(s)
    AC007991, AC087518
    Consensus CDS
    CCDS6114.3
    UniProtKB/Swiss-Prot
    A4UD41, F5H5G0, Q6ZQW0
    Conserved Domains (1) summary
    pfam01231
    Location:15 → 401
    IDO; Indoleamine 2,3-dioxygenase

  2. NM_194294.5 → NP_919270.3  indoleamine 2,3-dioxygenase 2

    Status: VALIDATED

    Source sequence(s)
    AC007991, AC087518
    Consensus CDS
    CCDS6114.3
    UniProtKB/Swiss-Prot
    A4UD41, F5H5G0, Q6ZQW0
    Related
    ENSP00000443432.2, ENST00000502986.4
    Conserved Domains (1) summary
    pfam01231
    Location:15 → 401
    IDO; Indoleamine 2,3-dioxygenase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    39934651..40016392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    40211488..40293321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQW0.5 GenPept UniProtKB/Swiss-Prot:Q6ZQW0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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