Gzmm granzyme M (lymphocyte met-ase 1) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gzmmprovided by MGI
Official Full Name: granzyme M (lymphocyte met-ase 1)provided by MGI
Primary source: MGI:MGI:99549
See related: Ensembl:ENSMUSG00000054206 AllianceGenome:MGI:99549
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lmet1; MMET-1
Summary: The protein encoded by this gene is a member of a family of cytotoxic lymphocyte serine proteases called granzymes, which are expressed by cytotoxic T lymphocytes and natural killer cells. This protein belongs to a subfamily of granzymes that cleave after methionine residues. Natural killer cell development, homeostasis and cytotoxicity are normal in mice deficient for this gene, but they demonstrate increased susceptibility to murine cytomegalovirus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression: Ubiquitous expression in heart adult (RPKM 1.8), placenta adult (RPKM 0.9) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79524854..79531095)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79689020..79695261)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GzMM has a critical role during early stages of inflammation in ulcerative colitis; in its absence colonic inflammation is enhanced.
Title: Granzyme M has a critical role in providing innate immune protection in ulcerative colitis.
Granzyme M regulates the release of natural killer cell MIP-1alpha to initiate innate immune responses.
Title: NK cell intrinsic regulation of MIP-1α by granzyme M.
Natural killer (NK) cell GrzM augments the inflammatory cascade downstream of lipopolysaccharide (LPS)-toll-like receptor (TLR)4 signaling, which ultimately results in lethal endotoxicosis.
Title: A role for granzyme M in TLR4-driven inflammation and endotoxicosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: granzyme M

Names: lymphoctye Met-ase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302485.1 → NP_001289414.1 granzyme M isoform 2 precursor

See identical proteins and their annotated locations for NP_001289414.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) utilizes an alternate in-frame splice site in the 5' coding region. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC151828, BG082217, CD742060

UniProtKB/TrEMBL

B7ZP17

Conserved Domains (2) summary

smart00020
Location:26 → 250

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:26 → 253

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_001302499.2 → NP_001289428.1 granzyme M isoform 3

See identical proteins and their annotated locations for NP_001289428.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains a distinct 5' UTR, lacks exons in the coding region, and utilizes a downstream start codon compared to variant 1. It encodes isoform 3, which is shorter than isoform 1. Variants 3 and 6-9 all encode the same isoform (3).

Source sequence(s)

AC151828

UniProtKB/TrEMBL

Q9R1W7

Related

ENSMUST00000151213.2

Conserved Domains (1) summary

cl21584
Location:2 → 100

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_001428556.1 → NP_001415485.1 granzyme M isoform 4

Status: REVIEWED

Source sequence(s)

AC151828
NM_001428558.1 → NP_001415487.1 granzyme M isoform 3

Status: REVIEWED

Source sequence(s)

AC151828
NM_001428559.1 → NP_001415488.1 granzyme M isoform 3

Status: REVIEWED

Source sequence(s)

AC151828
NM_001428560.1 → NP_001415489.1 granzyme M isoform 3

Status: REVIEWED

Source sequence(s)

AC151828
NM_001428561.1 → NP_001415490.1 granzyme M isoform 3

Status: REVIEWED

Source sequence(s)

AC151828
NM_008504.3 → NP_032530.1 granzyme M isoform 1 precursor

See identical proteins and their annotated locations for NP_032530.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC151828, BG082217, CD742060

Consensus CDS

CCDS23984.1

UniProtKB/TrEMBL

O08643

Related

ENSMUSP00000020549.3, ENSMUST00000020549.4

Conserved Domains (2) summary

smart00020
Location:27 → 251

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:27 → 254

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

NR_126325.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC151828, BE859680, BG082217, CD742060

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

79524854..79531095

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313816.3 → XP_017169305.1 granzyme M isoform X1

Conserved Domains (1) summary

cl21584
Location:2 → 100

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_006513277.4 → XP_006513340.1 granzyme M isoform X1

Conserved Domains (1) summary

cl21584
Location:2 → 100

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...