U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lect2 leukocyte cell-derived chemotaxin 2 [ Mus musculus (house mouse) ]

Gene ID: 16841, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Lect2provided by MGI
Official Full Name
leukocyte cell-derived chemotaxin 2provided by MGI
Primary source
MGI:MGI:1278342
See related
Ensembl:ENSMUSG00000021539 AllianceGenome:MGI:1278342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables identical protein binding activity. Acts upstream of or within negative regulation of Wnt signaling pathway. Predicted to be located in extracellular region. Is expressed in liver lobe; lung; and neural retina. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung adenocarcinoma. Orthologous to human LECT2 (leukocyte cell derived chemotaxin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 18.2), liver E14 (RPKM 7.9) and 3 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Lect2 in Genome Data Viewer
Location:
13 B1; 13 30.08 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (56676772..56696373, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (56529734..56548559, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 48 Neighboring gene interleukin 9 Neighboring gene STARR-positive B cell enhancer mm9_chr13:56623558-56623859 Neighboring gene F-box and leucine-rich repeat protein 21 Neighboring gene RIKEN cDNA 2010203P06 gene Neighboring gene STARR-seq mESC enhancer starr_34649 Neighboring gene transforming growth factor, beta induced

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. LECT2 Deletion Exacerbates Liver Steatosis and Macrophage Infiltration in a Male Mouse Model of LPS-mediated NASH. Tanida R, et al. Endocrinology, 2024 May 27. PMID 38781447
  2. Increase in hepatic NKT cells in leukocyte cell-derived chemotaxin 2-deficient mice contributes to severe concanavalin A-induced hepatitis. Saito T, et al. J Immunol, 2004 Jul 1. PMID 15210819
  3. Dynamic change in expression of LECT2 during liver regeneration after partial hepatectomy in mice. Ohtomi M, et al. Biomed Res, 2007 Oct. PMID 18000337
  4. Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II collagen antibody-induced arthritis. Okumura A, et al. Arthritis Rheum, 2008 Feb. PMID 18240267
  5. Regulation of neurite extension by expression of LECT2 and neurotrophins based on findings in LECT2-knockout mice. Koshimizu Y, et al. Brain Res, 2010 Jan 22. PMID 19917270

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of LECT2 in exacerbating atopic dermatitis: insight from in vivo and in vitro models via NF-kappaB signaling pathway.
    Title: Role of LECT2 in exacerbating atopic dermatitis: insight from in vivo and in vitro models via NF-κB signaling pathway.
  2. LECT2 Deletion Exacerbates Liver Steatosis and Macrophage Infiltration in a Male Mouse Model of LPS-mediated NASH.
    Title: LECT2 Deletion Exacerbates Liver Steatosis and Macrophage Infiltration in a Male Mouse Model of LPS-mediated NASH.
  3. LECT2 modulates dendritic cell function after Helicobacter pylori infection via the CD209a receptor.
    Title: LECT2 modulates dendritic cell function after Helicobacter pylori infection via the CD209a receptor.
  4. Liver infiltration of multiple immune cells during the process of acute liver injury and repair.
    Title: Liver infiltration of multiple immune cells during the process of acute liver injury and repair.
  5. Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET.
    Title: Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET.
  6. LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH.
    Title: LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH.
  7. Leukocyte cell-derived chemotaxin 2 promotes the development of nonalcoholic fatty liver disease through STAT-1 pathway in mice.
    Title: Leukocyte cell-derived chemotaxin 2 promotes the development of nonalcoholic fatty liver disease through STAT-1 pathway in mice.
  8. This study demonstrates the rapid response of LECT2 preceding body weight alterations during weight cycling in mice.
    Title: Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice.
  9. We found that treatment with LECT2 enhanced H. pylori killing and nitric oxide production in macrophages. In addition, DNA-binding activity and nuclear translocation of p65 were up-regulated by LECT2 treatment
    Title: LECT2 association with macrophage-mediated killing of Helicobacter pylori by activating NF-κB and nitric oxide production.
  10. LECT2 is regulated by beta-catenin in HCC in both mice and men, but serum LECT2 reflects beta-catenin activity only in mice. Serum LECT2 could be a potential biomarker of HCC in patients.
    Title: Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
leukocyte cell-derived chemotaxin-2
Names
LECT-2
chM-II
chondromodulin II

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010702.2 → NP_034832.2  leukocyte cell-derived chemotaxin-2 precursor

    See identical proteins and their annotated locations for NP_034832.2

    Status: VALIDATED

    Source sequence(s)
    AC132901, AI173435, AK131971
    Consensus CDS
    CCDS26564.1
    UniProtKB/Swiss-Prot
    O88803, O88804, Q3V287, Q8K181, Q9QWN3, Q9Z337
    UniProtKB/TrEMBL
    A0A0R4J0R8
    Related
    ENSMUSP00000060495.5, ENSMUST00000062806.6
    Conserved Domains (1) summary
    pfam01551
    Location:53 → 147
    Peptidase_M23; Peptidase family M23

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    56676772..56696373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157879.1 → XP_036013772.1  leukocyte cell-derived chemotaxin-2 isoform X1

    Conserved Domains (1) summary
    pfam01551
    Location:51 → 83
    Peptidase_M23; Peptidase family M23
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88803.1 GenPept UniProtKB/Swiss-Prot:O88803

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools