Lbx2 ladybird homeobox 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lbx2provided by MGI
Official Full Name: ladybird homeobox 2provided by MGI
Primary source: MGI:MGI:1342288
See related: Ensembl:ENSMUSG00000034968 AllianceGenome:MGI:1342288
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lbx2h
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including positive regulation of convergent extension involved in gastrulation; positive regulation of non-canonical Wnt signaling pathway; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including adrenal cortex; central nervous system; genitourinary system; neural retinal epithelium; and vibrissa. Orthologous to human LBX2 (ladybird homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in adrenal adult (RPKM 19.6), ovary adult (RPKM 6.5) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 35.94 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (83063346..83065224)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (83086365..83088243)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LBX2 has a role in ovarian maturation and folliculogenesis.
Title: Expression of ladybird-like homeobox 2 (LBX2) during ovarian development and folliculogenesis in the mouse.
Lbx1 is required for the expression of GlyT2, NPY, N/OFQ and is partially responsible for SOM expression.
Title: Ptf1a, Lbx1 and Pax2 coordinate glycinergic and peptidergic transmitter phenotypes in dorsal spinal inhibitory neurons.
our data suggest that the homeoprotein Lbx2 might be involved in the regulation of male reproductive system development and cell differentiation as well as in male epididymal segmentation
Title: Expression of the Ladybird-like homeobox 2 transcription factor in the developing mouse testis and epididymis.
Pax3 is required for Lbx2 expression in affected neural crest-derived tissues
Title: Generation of mice deficient for Lbx2, a gene expressed in the urogenital system, nervous system, and Pax3 dependent tissues.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6UmiJ4 (e-PCR), detects polymorphism
- UniSTS:260421

NoName (e-PCR)
- UniSTS:488276

Lbx2h (e-PCR), detects polymorphism
- UniSTS:226139

Lbx2h (e-PCR), detects polymorphism
- UniSTS:226140

NoName (e-PCR)
- UniSTS:487645

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of convergent extension involved in gastrulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of non-canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor LBX2

Names: lady bird-like homeobox 2 homolog; ladybird homeobox homolog 2; ladybird homeobox protein homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.