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TENT2 terminal nucleotidyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 167153, updated on 11-Apr-2024

Summary

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Official Symbol
TENT2provided by HGNC
Official Full Name
terminal nucleotidyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:26776
See related
Ensembl:ENSG00000164329 MIM:614121; AllianceGenome:HGNC:26776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APD4; GLD2; TUT2; PAPD4
Summary
Enables 5'-3' RNA polymerase activity and polynucleotide adenylyltransferase activity. Involved in RNA metabolic process and negative regulation of RNA catabolic process. Predicted to be located in nucleus. Predicted to be part of nuclear RNA-directed RNA polymerase complex. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 14.6), lymph node (RPKM 12.6) and 25 other tissues See more
Orthologs
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Genomic context

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See TENT2 in Genome Data Viewer
Location:
5q14.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (79612441..79688246)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (80096704..80172520)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (78908264..78984069)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901013 Neighboring gene uncharacterized LOC105379047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22726 Neighboring gene uncharacterized LOC124901014 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:78907869-78909068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:78925303-78925804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:78925805-78926304 Neighboring gene NANOG hESC enhancer GRCh37_chr5:78968175-78968748 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:78985169-78985670 Neighboring gene cardiomyopathy associated 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:79065865-79066605 Neighboring gene OCT4 hESC enhancer GRCh37_chr5:79067050-79067551 Neighboring gene uncharacterized LOC102724557

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Involvement of hGLD-2 in cytoplasmic polyadenylation of human p53 mRNA. Glahder JA, et al. APMIS, 2011 Nov. PMID 21995630
  2. Post-transcriptional generation of miRNA variants by multiple nucleotidyl transferases contributes to miRNA transcriptome complexity. Wyman SK, et al. Genome Res, 2011 Sep. PMID 21813625, Free PMC Article
  3. Hepatitis C Virus Core Protein Promotes miR-122 Destabilization by Inhibiting GLD-2. Kim GW, et al. PLoS Pathog, 2016 Jul. PMID 27366906, Free PMC Article
  4. The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs. Yamagishi R, et al. Nucleic Acids Res, 2016 Apr 7. PMID 26926106, Free PMC Article
  5. HBx down-regulated Gld2 plays a critical role in HBV-related dysregulation of miR-122. Peng F, et al. PLoS One, 2014. PMID 24667324, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance.
    Title: TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance.
  2. DDX6 is a positive regulator of Ataxin-2/PAPD4 cytoplasmic polyadenylation machinery.
    Title: DDX6 is a positive regulator of Ataxin-2/PAPD4 cytoplasmic polyadenylation machinery.
  3. The RNA-binding protein QKI-7 recruits the poly(A) polymerase GLD-2 for 3' adenylation and selective stabilization of microRNA-122.
    Title: The RNA-binding protein QKI-7 recruits the poly(A) polymerase GLD-2 for 3' adenylation and selective stabilization of microRNA-122.
  4. The data demonstrate a novel phosphorylation-dependent mechanism to regulate Gld2 activity, revealing tumour suppressor miRNAs(miR-122) as a previously unknown target of Akt1-dependent signalling
    Title: Gld2 activity is regulated by phosphorylation in the N-terminal domain.
  5. our results propose a novel feedback regulatory mechanism for controlling HCV RNA abundance by the viral capsid protein, which is capable of modulating miR-122 activity and stability through the inhibition of GLD-2.
    Title: Hepatitis C Virus Core Protein Promotes miR-122 Destabilization by Inhibiting GLD-2.
  6. QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs.
    Title: The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs.
  7. HBx is a critical protein derived from HBV, which regulates miR-122 via down-regulating Gld2
    Title: HBx down-regulated Gld2 plays a critical role in HBV-related dysregulation of miR-122.
  8. The noncanonical polymerase Gld2 has been implicated in the stabilization of miR-122, possibly through catalyzing 3' monoadenylation
    Title: Specific miRNA stabilization by Gld2-catalyzed monoadenylation.
  9. Study identified TUT7, TUT4, and TUT2 as novel components of the miRNA biogenesis pathway.
    Title: Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs.
  10. poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus
    Title: Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog
Novel locus FER is associated with serum HMW adiponectin levels.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38499

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in histone mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of miRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear RNA-directed RNA polymerase complex IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
poly(A) RNA polymerase GLD2
Names
PAP associated domain containing 4
PAP-associated domain-containing protein 4
TUTase 2
poly(A) RNA polymerase D4, non-canonical
terminal uridylyltransferase 2
NP_001107865.1
NP_001107866.1
NP_001284673.1
NP_001284674.1
NP_001336477.1
NP_001336478.1
NP_001336479.1
NP_001336480.1
NP_001336481.1
NP_001336482.1
NP_001336483.1
NP_001375022.1
NP_001375023.1
NP_001375024.1
NP_001375025.1
NP_001375026.1
NP_001375027.1
NP_001375028.1
NP_001375029.1
NP_001375030.1
NP_001375031.1
NP_001375032.1
NP_001375034.1
NP_001375035.1
NP_001375036.1
NP_001375037.1
NP_001375038.1
NP_001375039.1
NP_001375040.1
NP_001375041.1
NP_001375042.1
NP_001375043.1
NP_001375044.1
NP_001375045.1
NP_001375046.1
NP_001375047.1
NP_001375048.1
NP_001375049.1
NP_001375050.1
NP_001375051.1
NP_001375052.1
NP_001375053.1
NP_001375054.1
NP_001375055.1
NP_001375056.1
NP_001375057.1
NP_001375058.1
NP_001375059.1
NP_001375060.1
NP_001375061.1
NP_001375062.1
NP_001375063.1
NP_001375064.1
NP_001375065.1
NP_001375066.1
NP_776158.2
XP_011541522.1
XP_011541523.1
XP_011541526.1
XP_011541527.1
XP_011541531.1
XP_016864641.1
XP_047272800.1
XP_047272801.1
XP_047272802.1
XP_047272803.1
XP_047272804.1
XP_047272805.1
XP_047272806.1
XP_047272807.1
XP_047272808.1
XP_047272809.1
XP_047272810.1
XP_047272811.1
XP_047272812.1
XP_047272813.1
XP_047272814.1
XP_047272815.1
XP_047272816.1
XP_047272817.1
XP_047272818.1
XP_047272820.1
XP_054207855.1
XP_054207856.1
XP_054207857.1
XP_054207858.1
XP_054207859.1
XP_054207860.1
XP_054207861.1
XP_054207862.1
XP_054207863.1
XP_054207864.1
XP_054207865.1
XP_054207866.1
XP_054207867.1
XP_054207868.1
XP_054207869.1
XP_054207870.1
XP_054207871.1
XP_054207872.1
XP_054207873.1
XP_054207874.1
XP_054207875.1
XP_054207876.1
XP_054207877.1
XP_054207878.1
XP_054207879.1
XP_054207880.1
XP_054207881.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114393.3 → NP_001107865.1  poly(A) RNA polymerase GLD2 isoform 1

    See identical proteins and their annotated locations for NP_001107865.1

    Status: VALIDATED

    Source sequence(s)
    AC008482, AK095818, AW302247, BC047581, DA803910, DB302918
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927
    Conserved Domains (1) summary
    COG5260
    Location:154 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  2. NM_001114394.3 → NP_001107866.1  poly(A) RNA polymerase GLD2 isoform 1

    See identical proteins and their annotated locations for NP_001107866.1

    Status: VALIDATED

    Source sequence(s)
    AC008482, AK095818, AL833136, AW302247, BC047581, DA803910, DB302918
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927
    Related
    ENSP00000397563.1, ENST00000453514.6
    Conserved Domains (1) summary
    COG5260
    Location:154 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  3. NM_001297744.3 → NP_001284673.1  poly(A) RNA polymerase GLD2 isoform 2

    See identical proteins and their annotated locations for NP_001284673.1

    Status: VALIDATED

    Source sequence(s)
    AC008482, AW302247, BC047581, DB302918
    Consensus CDS
    CCDS75266.1
    UniProtKB/Swiss-Prot
    Q6PIY7
    Related
    ENSP00000393412.2, ENST00000423041.6
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  4. NM_001297745.3 → NP_001284674.1  poly(A) RNA polymerase GLD2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008482, AL833136, AW302247, BC047581, DB302918
    Consensus CDS
    CCDS75265.1
    UniProtKB/TrEMBL
    D6RAF2
    Related
    ENSP00000421966.1, ENST00000504233.5
    Conserved Domains (2) summary
    cd05402
    Location:176 → 298
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    COG5260
    Location:154 → 425
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  5. NM_001349548.2 → NP_001336477.1  poly(A) RNA polymerase GLD2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008482, AK095818, AW302247, BC047581, CN348312, DA803910, DB302918
    Conserved Domains (1) summary
    cl27230
    Location:4 → 245
    PAP_assoc; Cid1 family poly A polymerase

  6. NM_001349549.2 → NP_001336478.1  poly(A) RNA polymerase GLD2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008482, AK095818, AL833136, AW302247, BC047581, DA803910, DB302918
    Conserved Domains (1) summary
    COG5260
    Location:154 → 493
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  7. NM_001349550.2 → NP_001336479.1  poly(A) RNA polymerase GLD2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008482, AK095818, AW302247, BC047581, CF137152, CN348312, DA803910, DB302918
    Conserved Domains (1) summary
    COG5260
    Location:154 → 493
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  8. NM_001349551.2 → NP_001336480.1  poly(A) RNA polymerase GLD2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008482, AK095818, AL833136, AW302247, BC047581, DA803910, DB302918
    Conserved Domains (1) summary
    COG5260
    Location:154 → 489
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  9. NM_001349552.2 → NP_001336481.1  poly(A) RNA polymerase GLD2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008482, AK095818, AL833136, AW302247, BC047581, CF137152, CN348312, DA803910, DB302918
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927
    Conserved Domains (1) summary
    COG5260
    Location:154 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  10. NM_001349553.2 → NP_001336482.1  poly(A) RNA polymerase GLD2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008482, AK095818, AL833136, AW302247, BC047581, CF137152, CN348312, DA803910, DB302918
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927
    Conserved Domains (1) summary
    COG5260
    Location:154 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  11. NM_001349554.2 → NP_001336483.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482, AK095818, AL833136, AW302247, BC047581, CF137152, CN348312, DA803910, DB302918
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  12. NM_001388093.1 → NP_001375022.1  poly(A) RNA polymerase GLD2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (1) summary
    COG5260
    Location:154 → 493
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  13. NM_001388094.1 → NP_001375023.1  poly(A) RNA polymerase GLD2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (1) summary
    COG5260
    Location:154 → 493
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  14. NM_001388095.1 → NP_001375024.1  poly(A) RNA polymerase GLD2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (1) summary
    COG5260
    Location:154 → 489
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  15. NM_001388096.1 → NP_001375025.1  poly(A) RNA polymerase GLD2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (1) summary
    COG5260
    Location:154 → 489
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  16. NM_001388097.1 → NP_001375026.1  poly(A) RNA polymerase GLD2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (1) summary
    COG5260
    Location:154 → 489
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  17. NM_001388098.1 → NP_001375027.1  poly(A) RNA polymerase GLD2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (1) summary
    COG5260
    Location:153 → 488
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  18. NM_001388099.1 → NP_001375028.1  poly(A) RNA polymerase GLD2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (1) summary
    COG5260
    Location:154 → 478
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  19. NM_001388100.1 → NP_001375029.1  poly(A) RNA polymerase GLD2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (1) summary
    COG5260
    Location:154 → 478
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  20. NM_001388101.1 → NP_001375030.1  poly(A) RNA polymerase GLD2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (1) summary
    COG5260
    Location:154 → 474
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  21. NM_001388102.1 → NP_001375031.1  poly(A) RNA polymerase GLD2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927
    Conserved Domains (1) summary
    COG5260
    Location:154 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  22. NM_001388103.1 → NP_001375032.1  poly(A) RNA polymerase GLD2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927
    Conserved Domains (1) summary
    COG5260
    Location:154 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  23. NM_001388105.1 → NP_001375034.1  poly(A) RNA polymerase GLD2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927
    Conserved Domains (1) summary
    COG5260
    Location:154 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  24. NM_001388106.1 → NP_001375035.1  poly(A) RNA polymerase GLD2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927
    Conserved Domains (1) summary
    COG5260
    Location:154 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  25. NM_001388107.1 → NP_001375036.1  poly(A) RNA polymerase GLD2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927
    Conserved Domains (1) summary
    COG5260
    Location:154 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  26. NM_001388108.1 → NP_001375037.1  poly(A) RNA polymerase GLD2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927
    Conserved Domains (1) summary
    COG5260
    Location:154 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  27. NM_001388109.1 → NP_001375038.1  poly(A) RNA polymerase GLD2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927
    Conserved Domains (1) summary
    COG5260
    Location:154 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  28. NM_001388110.1 → NP_001375039.1  poly(A) RNA polymerase GLD2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927
    Conserved Domains (1) summary
    COG5260
    Location:154 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  29. NM_001388111.1 → NP_001375040.1  poly(A) RNA polymerase GLD2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927
    Conserved Domains (1) summary
    COG5260
    Location:154 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  30. NM_001388112.1 → NP_001375041.1  poly(A) RNA polymerase GLD2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927
    Conserved Domains (1) summary
    COG5260
    Location:154 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  31. NM_001388113.1 → NP_001375042.1  poly(A) RNA polymerase GLD2 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (1) summary
    COG5260
    Location:153 → 467
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  32. NM_001388114.1 → NP_001375043.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  33. NM_001388115.1 → NP_001375044.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  34. NM_001388116.1 → NP_001375045.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  35. NM_001388117.1 → NP_001375046.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  36. NM_001388118.1 → NP_001375047.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  37. NM_001388119.1 → NP_001375048.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  38. NM_001388120.1 → NP_001375049.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  39. NM_001388121.1 → NP_001375050.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  40. NM_001388122.1 → NP_001375051.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  41. NM_001388123.1 → NP_001375052.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  42. NM_001388124.1 → NP_001375053.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  43. NM_001388125.1 → NP_001375054.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  44. NM_001388126.1 → NP_001375055.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  45. NM_001388127.1 → NP_001375056.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  46. NM_001388128.1 → NP_001375057.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  47. NM_001388129.1 → NP_001375058.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    COG5260
    Location:154 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  48. NM_001388130.1 → NP_001375059.1  poly(A) RNA polymerase GLD2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (1) summary
    COG5260
    Location:153 → 463
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  49. NM_001388131.1 → NP_001375060.1  poly(A) RNA polymerase GLD2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (1) summary
    COG5260
    Location:124 → 438
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  50. NM_001388132.1 → NP_001375061.1  poly(A) RNA polymerase GLD2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (1) summary
    COG5260
    Location:124 → 434
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  51. NM_001388133.1 → NP_001375062.1  poly(A) RNA polymerase GLD2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Consensus CDS
    CCDS75265.1
    UniProtKB/TrEMBL
    D6RAF2
    Conserved Domains (2) summary
    cd05402
    Location:176 → 298
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    COG5260
    Location:154 → 425
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  52. NM_001388134.1 → NP_001375063.1  poly(A) RNA polymerase GLD2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (2) summary
    cd05402
    Location:176 → 294
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    COG5260
    Location:154 → 421
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  53. NM_001388135.1 → NP_001375064.1  poly(A) RNA polymerase GLD2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (2) summary
    cd05402
    Location:176 → 294
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    COG5260
    Location:154 → 421
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  54. NM_001388136.1 → NP_001375065.1  poly(A) RNA polymerase GLD2 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (1) summary
    COG5260
    Location:38 → 348
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  55. NM_001388137.1 → NP_001375066.1  poly(A) RNA polymerase GLD2 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC008482
    Conserved Domains (2) summary
    COG5260
    Location:81 → 270
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    cl11966
    Location:36 → 100
    NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins

  56. NM_173797.5 → NP_776158.2  poly(A) RNA polymerase GLD2 isoform 1

    See identical proteins and their annotated locations for NP_776158.2

    Status: VALIDATED

    Source sequence(s)
    AC008482, AK095818, AW302247, BC047581, CN348312, DA803910, DB302918
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927
    Related
    ENSP00000296783.3, ENST00000296783.7
    Conserved Domains (1) summary
    COG5260
    Location:154 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    79612441..79688246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543221.4 → XP_011541523.1  poly(A) RNA polymerase GLD2 isoform X1

    See identical proteins and their annotated locations for XP_011541523.1

    Conserved Domains (1) summary
    COG5260
    Location:154 → 493
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  2. XM_047416850.1 → XP_047272806.1  poly(A) RNA polymerase GLD2 isoform X3

    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927

  3. XM_047416857.1 → XP_047272813.1  poly(A) RNA polymerase GLD2 isoform X6

    UniProtKB/TrEMBL
    D6RAF2

  4. XM_047416846.1 → XP_047272802.1  poly(A) RNA polymerase GLD2 isoform X2

  5. XM_011543220.4 → XP_011541522.1  poly(A) RNA polymerase GLD2 isoform X1

    See identical proteins and their annotated locations for XP_011541522.1

    Conserved Domains (1) summary
    COG5260
    Location:154 → 493
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  6. XM_047416856.1 → XP_047272812.1  poly(A) RNA polymerase GLD2 isoform X6

    UniProtKB/TrEMBL
    D6RAF2

  7. XM_017009152.3 → XP_016864641.1  poly(A) RNA polymerase GLD2 isoform X2

    Conserved Domains (1) summary
    COG5260
    Location:154 → 489
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  8. XM_047416859.1 → XP_047272815.1  poly(A) RNA polymerase GLD2 isoform X7

  9. XM_011543229.4 → XP_011541531.1  poly(A) RNA polymerase GLD2 isoform X5

    Conserved Domains (2) summary
    cd05402
    Location:176 → 323
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam03828
    Location:368 → 422
    PAP_assoc; Cid1 family poly A polymerase

  10. XM_047416851.1 → XP_047272807.1  poly(A) RNA polymerase GLD2 isoform X3

    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927

  11. XM_047416853.1 → XP_047272809.1  poly(A) RNA polymerase GLD2 isoform X4

  12. XM_047416844.1 → XP_047272800.1  poly(A) RNA polymerase GLD2 isoform X1

  13. XM_047416852.1 → XP_047272808.1  poly(A) RNA polymerase GLD2 isoform X3

    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927

  14. XM_047416848.1 → XP_047272804.1  poly(A) RNA polymerase GLD2 isoform X2

  15. XM_047416854.1 → XP_047272810.1  poly(A) RNA polymerase GLD2 isoform X4

  16. XM_011543225.3 → XP_011541527.1  poly(A) RNA polymerase GLD2 isoform X1

    See identical proteins and their annotated locations for XP_011541527.1

    Conserved Domains (1) summary
    COG5260
    Location:154 → 493
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  17. XM_047416858.1 → XP_047272814.1  poly(A) RNA polymerase GLD2 isoform X6

    UniProtKB/TrEMBL
    D6RAF2

  18. XM_047416845.1 → XP_047272801.1  poly(A) RNA polymerase GLD2 isoform X1

  19. XM_047416849.1 → XP_047272805.1  poly(A) RNA polymerase GLD2 isoform X2

  20. XM_047416855.1 → XP_047272811.1  poly(A) RNA polymerase GLD2 isoform X4

  21. XM_011543224.3 → XP_011541526.1  poly(A) RNA polymerase GLD2 isoform X1

    See identical proteins and their annotated locations for XP_011541526.1

    Conserved Domains (1) summary
    COG5260
    Location:154 → 493
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  22. XM_047416847.1 → XP_047272803.1  poly(A) RNA polymerase GLD2 isoform X2

  23. XM_047416862.1 → XP_047272818.1  poly(A) RNA polymerase GLD2 isoform X10

  24. XM_047416860.1 → XP_047272816.1  poly(A) RNA polymerase GLD2 isoform X8

  25. XM_047416861.1 → XP_047272817.1  poly(A) RNA polymerase GLD2 isoform X9

  26. XM_047416864.1 → XP_047272820.1  poly(A) RNA polymerase GLD2 isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    80096704..80172520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351881.1 → XP_054207856.1  poly(A) RNA polymerase GLD2 isoform X1

  2. XM_054351891.1 → XP_054207866.1  poly(A) RNA polymerase GLD2 isoform X3

    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927

  3. XM_054351899.1 → XP_054207874.1  poly(A) RNA polymerase GLD2 isoform X6

    UniProtKB/TrEMBL
    D6RAF2

  4. XM_054351887.1 → XP_054207862.1  poly(A) RNA polymerase GLD2 isoform X2

  5. XM_054351880.1 → XP_054207855.1  poly(A) RNA polymerase GLD2 isoform X1

  6. XM_054351898.1 → XP_054207873.1  poly(A) RNA polymerase GLD2 isoform X6

    UniProtKB/TrEMBL
    D6RAF2

  7. XM_054351886.1 → XP_054207861.1  poly(A) RNA polymerase GLD2 isoform X2

  8. XM_054351901.1 → XP_054207876.1  poly(A) RNA polymerase GLD2 isoform X7

  9. XM_054351897.1 → XP_054207872.1  poly(A) RNA polymerase GLD2 isoform X5

  10. XM_054351892.1 → XP_054207867.1  poly(A) RNA polymerase GLD2 isoform X3

    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927

  11. XM_054351894.1 → XP_054207869.1  poly(A) RNA polymerase GLD2 isoform X4

  12. XM_054351884.1 → XP_054207859.1  poly(A) RNA polymerase GLD2 isoform X1

  13. XM_054351893.1 → XP_054207868.1  poly(A) RNA polymerase GLD2 isoform X3

    UniProtKB/Swiss-Prot
    Q6PIY7, Q86WZ2, Q8N927

  14. XM_054351889.1 → XP_054207864.1  poly(A) RNA polymerase GLD2 isoform X2

  15. XM_054351895.1 → XP_054207870.1  poly(A) RNA polymerase GLD2 isoform X4

  16. XM_054351883.1 → XP_054207858.1  poly(A) RNA polymerase GLD2 isoform X1

  17. XM_054351900.1 → XP_054207875.1  poly(A) RNA polymerase GLD2 isoform X6

    UniProtKB/TrEMBL
    D6RAF2

  18. XM_054351885.1 → XP_054207860.1  poly(A) RNA polymerase GLD2 isoform X1

  19. XM_054351890.1 → XP_054207865.1  poly(A) RNA polymerase GLD2 isoform X2

  20. XM_054351896.1 → XP_054207871.1  poly(A) RNA polymerase GLD2 isoform X4

  21. XM_054351882.1 → XP_054207857.1  poly(A) RNA polymerase GLD2 isoform X1

  22. XM_054351888.1 → XP_054207863.1  poly(A) RNA polymerase GLD2 isoform X2

  23. XM_054351906.1 → XP_054207881.1  poly(A) RNA polymerase GLD2 isoform X11

  24. XM_054351904.1 → XP_054207879.1  poly(A) RNA polymerase GLD2 isoform X10

  25. XM_054351902.1 → XP_054207877.1  poly(A) RNA polymerase GLD2 isoform X8

  26. XM_054351903.1 → XP_054207878.1  poly(A) RNA polymerase GLD2 isoform X9

  27. XM_054351905.1 → XP_054207880.1  poly(A) RNA polymerase GLD2 isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PIY7.1 GenPept UniProtKB/Swiss-Prot:Q6PIY7

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