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CDC20B cell division cycle 20B [ Homo sapiens (human) ]

Gene ID: 166979, updated on 5-Mar-2024

Summary

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Official Symbol
CDC20Bprovided by HGNC
Official Full Name
cell division cycle 20Bprovided by HGNC
Primary source
HGNC:HGNC:24222
See related
Ensembl:ENSG00000164287 MIM:620335; AllianceGenome:HGNC:24222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G6VTS76519
Summary
Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process and positive regulation of anaphase-promoting complex-dependent catabolic process. Predicted to be part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See CDC20B in Genome Data Viewer
Location:
5q11.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (55112971..55173177, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (55940297..56000463, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (54408799..54469005, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene granzyme A pseudogene 1 Neighboring gene granzyme A Neighboring gene Sharpr-MPRA regulatory region 4084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16009 Neighboring gene glutathione peroxidase 8 (putative) Neighboring gene microRNA 449a Neighboring gene microRNA 449b Neighboring gene microRNA 449c Neighboring gene MPRA-validated peak5244 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22551 Neighboring gene Sharpr-MPRA regulatory region 9706 Neighboring gene uncharacterized LOC124900978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:54527615-54528254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:54528255-54528894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16013 Neighboring gene Sharpr-MPRA regulatory region 6084 Neighboring gene multiciliate differentiation and DNA synthesis associated cell cycle protein Neighboring gene cyclin O

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Circular RNA hsa_circ_0008896 accelerates atherosclerosis by promoting the proliferation, migration and invasion of vascular smooth muscle cells via hsa-miR-633/CDC20B (cell division cycle 20B) axis. Hou X, et al. Bioengineered, 2022 Mar. PMID 35212610, Free PMC Article
  2. CDC20B is required for deuterosome-mediated centriole production in multiciliated cells. Revinski DR, et al. Nat Commun, 2018 Nov 7. PMID 30405130, Free PMC Article
  3. A Whole-Genome CRISPR Screen Identifies AHR Loss as a Mechanism of Resistance to a PARP7 Inhibitor. Chen H, et al. Mol Cancer Ther, 2022 Jul 5. PMID 35439318, Free PMC Article
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular RNA hsa_circ_0008896 accelerates atherosclerosis by promoting the proliferation, migration and invasion of vascular smooth muscle cells via hsa-miR-633/CDC20B (cell division cycle 20B) axis.
    Title: Circular RNA hsa_circ_0008896 accelerates atherosclerosis by promoting the proliferation, migration and invasion of vascular smooth muscle cells via hsa-miR-633/CDC20B (cell division cycle 20B) axis.
  2. CDC20B protein associates to deuterosomes and is required for centriole release and subsequent cilia production.
    Title: CDC20B is required for deuterosome-mediated centriole production in multiciliated cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37927

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables anaphase-promoting complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin ligase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in de novo centriole assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in deuterosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cell division cycle protein 20 homolog B
Names
CDC20 cell division cycle 20 homolog B
CDC20-like protein
cell division cycle 20 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145734.2 → NP_001139206.2  cell division cycle protein 20 homolog B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region but maintains the reading frame, compared to variant 3. This variant encodes isoform 2, which is shorter than isoform 3.
    Source sequence(s)
    AB086378, AC091977, AK095246, DB237622
    Consensus CDS
    CCDS47207.1
    UniProtKB/Swiss-Prot
    Q86Y33
    Related
    ENSP00000315720.6, ENST00000322374.10
    Conserved Domains (3) summary
    COG2319
    Location:183 → 476
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:277 → 313
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:236 → 475
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001170402.1 → NP_001163873.1  cell division cycle protein 20 homolog B isoform 3

    See identical proteins and their annotated locations for NP_001163873.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC091977, AK095246, BC136572, DB237622
    Consensus CDS
    CCDS54852.1
    UniProtKB/Swiss-Prot
    B7WNV8, B9EGL8, C9J6X8, C9JHE9, C9JKL5, Q86Y31, Q86Y32, Q86Y33, Q8IUZ8, Q8N1S1, Q8NG56
    Related
    ENSP00000370781.2, ENST00000381375.7
    Conserved Domains (3) summary
    COG2319
    Location:230 → 518
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:276 → 313
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:276 → 517
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_152623.2 → NP_689836.2  cell division cycle protein 20 homolog B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. This results in a shorter protein (isoform 1), compared to isoform 3.
    Source sequence(s)
    AC091977, AI471861, AK095246, DB237622
    Consensus CDS
    CCDS3966.1
    UniProtKB/Swiss-Prot
    Q86Y33
    Related
    ENSP00000296733.1, ENST00000296733.5
    Conserved Domains (3) summary
    COG2319
    Location:230 → 514
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:276 → 313
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:276 → 513
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    55112971..55173177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    55940297..56000463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86Y33.3 GenPept UniProtKB/Swiss-Prot:Q86Y33

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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