Krt2 keratin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt2provided by MGI
Official Full Name: keratin 2provided by MGI
Primary source: MGI:MGI:96699
See related: Ensembl:ENSMUSG00000064201 AllianceGenome:MGI:96699
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Krt2e; Krt2-2; Krt2-17
Summary: Enables cytoskeletal protein binding activity. A structural constituent of skin epidermis. Involved in positive regulation of epidermis development. Acts upstream of or within intermediate filament organization and keratinocyte development. Located in cytoplasm and keratin filament. Is expressed in several structures, including gut; integumental system; male reproductive gland or organ; nervous system; and neural retina. Used to study bullous congenital ichthyosiform erythroderma. Human ortholog(s) of this gene implicated in bullous congenital ichthyosiform erythroderma and ichthyosis. Orthologous to human KRT2 (keratin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 15 F2; 15 57.03 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101719124..101727391, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101810689..101818956, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrates that the loss of the main cytoskeletal components of plantar epidermis, i.e. K2 and K10, can be only partly compensated by the upregulation of other keratins.
Title: Keratins K2 and K10 are essential for the epidermal integrity of plantar skin.
Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation.
Title: Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation.
increased CK2/SIRT1 expression by cilostazol can be a therapeutic strategy to suppress the tau-related neurodegeneration in the Alzheimer's disease brain
Title: Attenuation of β-amyloid-induced tauopathy via activation of CK2α/SIRT1: targeting for cilostazol.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC200956P1 (e-PCR)
- UniSTS:271874

NoName (e-PCR)
- UniSTS:224397

BB005427 (e-PCR)
- UniSTS:186048

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of skin epidermis	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of skin epidermis	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intermediate filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IEA Inferred from Electronic Annotation more info
involved_in keratinization	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte activation	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within keratinocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in keratinocyte migration	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte migration	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in peptide cross-linking	IEA Inferred from Electronic Annotation more info
involved_in peptide cross-linking	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cornified envelope	IEA Inferred from Electronic Annotation more info
located_in cornified envelope	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: keratin, type II cytoskeletal 2 epidermal

Names: CK-2e; K2e; cytokeratin-2e; epithelial keratin-2e; keratin 2 epidermis; keratin complex 2, basic, gene 17; keratin complex 2, gene 17; keratin-2e; type-II keratin Kb2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010668.2 → NP_034798.2 keratin, type II cytoskeletal 2 epidermal

See identical proteins and their annotated locations for NP_034798.2

Status: VALIDATED

Source sequence(s)

AK161078, AK161098, BE945724

Consensus CDS

CCDS37220.1

UniProtKB/Swiss-Prot

Q0VBW1, Q3TTY5, Q61869

Related

ENSMUSP00000023712.8, ENSMUST00000023712.8

Conserved Domains (2) summary

pfam00038
Location:198 → 511

Filament; Intermediate filament protein

pfam16208
Location:29 → 80

Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

101719124..101727391 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248357.1 → XP_030104217.1 keratin, type II cytoskeletal 2 epidermal isoform X1

Conserved Domains (2) summary

pfam00038
Location:144 → 457

Filament; Intermediate filament protein

pfam16208
Location:14 → 141

Keratin_2_head; Keratin type II head