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Klf12 Kruppel-like transcription factor 12 [ Mus musculus (house mouse) ]

Gene ID: 16597, updated on 11-Nov-2024

Summary

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Official Symbol
Klf12provided by MGI
Official Full Name
Kruppel-like transcription factor 12provided by MGI
Primary source
MGI:MGI:1333796
See related
Ensembl:ENSMUSG00000072294 AllianceGenome:MGI:1333796
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AP-2rep; 2700063E05Rik; B130052C06Rik; D530033K05Rik
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human KLF12 (KLF transcription factor 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in whole brain E14.5 (RPKM 4.9), CNS E14 (RPKM 4.0) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Klf12 in Genome Data Viewer
Location:
14 E2.2- E2.3; 14 50.9 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (100103617..100719681, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (99866181..100285891, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37452 Neighboring gene predicted gene, 22970 Neighboring gene predicted pseudogene 5958 Neighboring gene RIKEN cDNA 2810416A17 gene Neighboring gene STARR-seq mESC enhancer starr_37454 Neighboring gene STARR-seq mESC enhancer starr_37455 Neighboring gene RIKEN cDNA 4930517O19 gene Neighboring gene STARR-positive B cell enhancer mm9_chr14:100610424-100610725 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37462 Neighboring gene predicted gene, 41231 Neighboring gene STARR-seq mESC enhancer starr_37463 Neighboring gene STARR-positive B cell enhancer mm9_chr14:100858327-100858628 Neighboring gene STARR-positive B cell enhancer mm9_chr14:100860836-100861137 Neighboring gene predicted gene, 34199 Neighboring gene predicted gene, 26367 Neighboring gene predicted gene, 24345 Neighboring gene ribosomal protein L10A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KLF12 Regulates Mouse NK Cell Proliferation. Lam VC, et al. J Immunol, 2019 Aug 15. PMID 31300511, Free PMC Article
  2. Regulation of KLF12 by microRNA-20b and microRNA-106a in cystogenesis. Shin Y, et al. FASEB J, 2018 Jul. PMID 29475398
  3. Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12). Roth C, et al. Genomics, 2000 Feb 1. PMID 10704285
  4. KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer. Pan X, et al. Mol Oncol, 2023 Dec. PMID 37606530, Free PMC Article
  5. A high level of KLF12 causes folic acid-resistant neural tube defects by activating the Shh signaling pathway in mice†. Liu Y, et al. Biol Reprod, 2021 Oct 11. PMID 34104947

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer.
    Title: KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer.
  2. A high level of KLF12 causes folic acid-resistant neural tube defects by activating the Shh signaling pathway in micedagger.
    Title: A high level of KLF12 causes folic acid-resistant neural tube defects by activating the Shh signaling pathway in mice†.
  3. we found that KLF12 regulates mouse NK cell proliferation
    Title: KLF12 Regulates Mouse NK Cell Proliferation.
  4. Klf12 expression is down-regulated in kidney tissues of Pkd2f/f mice. miR-20b-5p and miR-106a-5p directly target Klf12 mRNA by binding to the 3'-UTR of Klf12.
    Title: Regulation of KLF12 by microRNA-20b and microRNA-106a in cystogenesis.
  5. KLF12 is involved in the maturation processes of collecting ducts after birth, and UT-A1 is a target gene of KLF12.
    Title: Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Krueppel-like factor 12
Names
Kruppel-like factor 12
transcriptional repressor AP-2rep

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411709.1 → NP_001398638.1  Krueppel-like factor 12

    Status: VALIDATED

    Source sequence(s)
    AC113486, AC116856, AC117638, AC125446
    UniProtKB/Swiss-Prot
    O35738, Q6NWV9
    Related
    ENSMUSP00000153901.2, ENSMUST00000228216.2

  2. NM_010636.4 → NP_034766.2  Krueppel-like factor 12

    See identical proteins and their annotated locations for NP_034766.2

    Status: VALIDATED

    Source sequence(s)
    AC113486, AC116856, AC117638, AC125446
    Consensus CDS
    CCDS36998.1
    UniProtKB/Swiss-Prot
    O35738, Q6NWV9
    Conserved Domains (4) summary
    COG5048
    Location:225 → 401
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319 → 341
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:363 → 388
    zf-H2C2_2; Zinc-finger double domain
    cd21441
    Location:27 → 224
    KLF12_N; N-terminal domain of Kruppel-like factor 12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    100103617..100719681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158486.1 → XP_036014379.1  Krueppel-like factor 12 isoform X1

    UniProtKB/Swiss-Prot
    O35738, Q6NWV9
    Related
    ENSMUSP00000094844.5, ENSMUST00000097079.5
    Conserved Domains (4) summary
    COG5048
    Location:225 → 401
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319 → 341
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:363 → 388
    zf-H2C2_2; Zinc-finger double domain
    cd21441
    Location:27 → 224
    KLF12_N; N-terminal domain of Kruppel-like factor 12

  2. XM_011244971.4 → XP_011243273.1  Krueppel-like factor 12 isoform X3

    See identical proteins and their annotated locations for XP_011243273.1

    Conserved Domains (3) summary
    COG5048
    Location:206 → 382
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:300 → 322
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:344 → 369
    zf-H2C2_2; Zinc-finger double domain

  3. XM_036158490.1 → XP_036014383.1  Krueppel-like factor 12 isoform X4

    Conserved Domains (4) summary
    COG5048
    Location:175 → 351
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:269 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:313 → 338
    zf-H2C2_2; Zinc-finger double domain
    cl40450
    Location:1 → 174
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

  4. XM_030247664.2 → XP_030103524.1  Krueppel-like factor 12 isoform X4

    Conserved Domains (4) summary
    COG5048
    Location:175 → 351
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:269 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:313 → 338
    zf-H2C2_2; Zinc-finger double domain
    cl40450
    Location:1 → 174
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

  5. XM_036158488.1 → XP_036014381.1  Krueppel-like factor 12 isoform X4

    Conserved Domains (4) summary
    COG5048
    Location:175 → 351
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:269 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:313 → 338
    zf-H2C2_2; Zinc-finger double domain
    cl40450
    Location:1 → 174
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

  6. XM_036158485.1 → XP_036014378.1  Krueppel-like factor 12 isoform X1

    UniProtKB/Swiss-Prot
    O35738, Q6NWV9
    Conserved Domains (4) summary
    COG5048
    Location:225 → 401
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319 → 341
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:363 → 388
    zf-H2C2_2; Zinc-finger double domain
    cd21441
    Location:27 → 224
    KLF12_N; N-terminal domain of Kruppel-like factor 12

  7. XM_006518625.5 → XP_006518688.1  Krueppel-like factor 12 isoform X3

    See identical proteins and their annotated locations for XP_006518688.1

    Conserved Domains (3) summary
    COG5048
    Location:206 → 382
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:300 → 322
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:344 → 369
    zf-H2C2_2; Zinc-finger double domain

  8. XM_017315889.3 → XP_017171378.1  Krueppel-like factor 12 isoform X4

    Conserved Domains (4) summary
    COG5048
    Location:175 → 351
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:269 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:313 → 338
    zf-H2C2_2; Zinc-finger double domain
    cl40450
    Location:1 → 174
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

  9. XM_036158489.1 → XP_036014382.1  Krueppel-like factor 12 isoform X4

    Conserved Domains (4) summary
    COG5048
    Location:175 → 351
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:269 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:313 → 338
    zf-H2C2_2; Zinc-finger double domain
    cl40450
    Location:1 → 174
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

  10. XM_030247662.2 → XP_030103522.1  Krueppel-like factor 12 isoform X4

    Conserved Domains (4) summary
    COG5048
    Location:175 → 351
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:269 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:313 → 338
    zf-H2C2_2; Zinc-finger double domain
    cl40450
    Location:1 → 174
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

  11. XM_036158487.1 → XP_036014380.1  Krueppel-like factor 12 isoform X4

    Conserved Domains (4) summary
    COG5048
    Location:175 → 351
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:269 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:313 → 338
    zf-H2C2_2; Zinc-finger double domain
    cl40450
    Location:1 → 174
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

  12. XM_011244970.4 → XP_011243272.1  Krueppel-like factor 12 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:218 → 394
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312 → 334
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:356 → 381
    zf-H2C2_2; Zinc-finger double domain

  13. XM_011244968.4 → XP_011243270.1  Krueppel-like factor 12 isoform X1

    See identical proteins and their annotated locations for XP_011243270.1

    UniProtKB/Swiss-Prot
    O35738, Q6NWV9
    Conserved Domains (4) summary
    COG5048
    Location:225 → 401
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319 → 341
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:363 → 388
    zf-H2C2_2; Zinc-finger double domain
    cd21441
    Location:27 → 224
    KLF12_N; N-terminal domain of Kruppel-like factor 12

  14. XM_036158491.1 → XP_036014384.1  Krueppel-like factor 12 isoform X5

    Conserved Domains (1) summary
    cl40450
    Location:27 → 224
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

  15. XM_036158492.1 → XP_036014385.1  Krueppel-like factor 12 isoform X6

    Conserved Domains (1) summary
    cl40450
    Location:27 → 224
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35738.2 GenPept UniProtKB/Swiss-Prot:O35738

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