Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnn4provided by MGI
Official Full Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4provided by MGI
Primary source: MGI:MGI:1277957
See related: Ensembl:ENSMUSG00000054342 AllianceGenome:MGI:1277957
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IK1; SK4; KCA4; mIK1; IKCA1; SKCas; mKCa4; KCa3.1; mIKCa1
Summary: Enables intermediate conductance calcium-activated potassium channel activity. Involved in potassium ion transmembrane transport. Acts upstream of or within several processes, including cell volume homeostasis; phospholipid translocation; and saliva secretion. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytosol. Predicted to be active in neuron projection; neuronal cell body; and plasma membrane. Is expressed in several structures, including alimentary system; liver; metanephros; nervous system; and skeleton. Human ortholog(s) of this gene implicated in angiosarcoma; cerebral infarction; dehydrated hereditary stomatocytosis 2; hypertension; and myocardial infarction. Orthologous to human KCNN4 (potassium calcium-activated channel subfamily N member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 85.0), liver E14.5 (RPKM 56.8) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 10.37 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (24069750..24084635)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (24369826..24385212)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

M2 macrophage-derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL-1 myocytes via the NF-kappaB (p65)/STAT3 signaling pathway.
Title: M2 macrophage‑derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL‑1 myocytes via the NF‑κB (p65)/STAT3 signaling pathway.
KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation.
Title: KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation.
Endothelial KCa3.1 and KCa2.3 Mediate S1P (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure Homeostasis.
Title: Endothelial K(Ca)3.1 and K(Ca)2.3 Mediate S1P (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure Homeostasis.
Involvement of KCa3.1 channel activity in immediate perioperative cognitive and neuroinflammatory outcomes.
Title: Involvement of KCa3.1 channel activity in immediate perioperative cognitive and neuroinflammatory outcomes.
KCa3.1 inhibition-induced activation of the JNK/c-Jun signaling pathway enhances IL-10 expression in peripherally-induced regulatory T cells.
Title: K(Ca)3.1 inhibition-induced activation of the JNK/c-Jun signaling pathway enhances IL-10 expression in peripherally-induced regulatory T cells.
Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection.
Title: Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection.
Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease.
Title: Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease.
Downregulation of the Ca(2+)-activated K(+) channel KCa3.1 in mouse preosteoblast cells treated with vitamin D receptor agonist.
Title: Downregulation of the Ca(2+)-activated K(+) channel K(Ca)3.1 in mouse preosteoblast cells treated with vitamin D receptor agonist.
Gal-3 (Galectin-3) and KCa3.1 Mediate Heterogeneous Cell Coupling and Myocardial Fibrogenesis Driven by betaAR (beta-Adrenoceptor) Activation.
Title: Gal-3 (Galectin-3) and K(Ca)3.1 Mediate Heterogeneous Cell Coupling and Myocardial Fibrogenesis Driven by βAR (β-Adrenoceptor) Activation.
Macrophages facilitate post myocardial infarction arrhythmias: roles of gap junction and KCa3.1.
Title: Macrophages facilitate post myocardial infarction arrhythmias: roles of gap junction and KCa3.1.

Submit: New GeneRIF Correction See all GeneRIFs (87)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kcnn4 (e-PCR), detects polymorphism
- UniSTS:143673

AF042487 (e-PCR)
- UniSTS:163411

Kcnn4 (e-PCR), detects polymorphism
- UniSTS:507006

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-activated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables intermediate conductance calcium-activated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intermediate conductance calcium-activated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables intermediate conductance calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables small conductance calcium-activated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell volume homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hepatocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in macropinocytosis	IEA Inferred from Electronic Annotation more info
involved_in monoatomic anion transport	ISO Inferred from Sequence Orthology more info
involved_in mononuclear cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell volume	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hepatic stellate cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid translocation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G0 to G1 transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of angiotensin levels in blood	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of renin secretion into blood stream	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within saliva secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in stabilization of membrane potential	IEA Inferred from Electronic Annotation more info
involved_in stabilization of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in vesicle	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: intermediate conductance calcium-activated potassium channel protein 4

Names: SKCa 4; SKCa4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163510.2 → NP_001156982.1 intermediate conductance calcium-activated potassium channel protein 4 isoform a

See identical proteins and their annotated locations for NP_001156982.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (a). Variants 1-3 all encode the same isoform (a).

Source sequence(s)

AC159140

Consensus CDS

CCDS20948.1

UniProtKB/Swiss-Prot

O89109, Q3U1J8, Q9CY39

Related

ENSMUSP00000133065.2, ENSMUST00000171904.3

Conserved Domains (3) summary

smart01053
Location:302 → 374

CaMBD; Calmodulin binding domain

pfam03530
Location:15 → 121

SK_channel; Calcium-activated SK potassium channel

pfam07885
Location:235 → 288

Ion_trans_2; Ion channel
NM_001412606.1 → NP_001399535.1 intermediate conductance calcium-activated potassium channel protein 4 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 2. Variants 1-3 all encode the same isoform (a).

Source sequence(s)

AC159140

UniProtKB/Swiss-Prot

O89109, Q3U1J8, Q9CY39
NM_001412607.1 → NP_001399536.1 intermediate conductance calcium-activated potassium channel protein 4 isoform b

Status: VALIDATED

Source sequence(s)

AC159140
NM_001412608.1 → NP_001399537.1 intermediate conductance calcium-activated potassium channel protein 4 isoform c

Status: VALIDATED

Source sequence(s)

AC159140
NM_001412609.1 → NP_001399538.1 intermediate conductance calcium-activated potassium channel protein 4 isoform b

Status: VALIDATED

Source sequence(s)

AC159140
NM_008433.5 → NP_032459.3 intermediate conductance calcium-activated potassium channel protein 4 isoform a

See identical proteins and their annotated locations for NP_032459.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 3' UTR compared to variant 2. Variants 1-3 all encode the same isoform (a).

Source sequence(s)

AC159140

Consensus CDS

CCDS20948.1

UniProtKB/Swiss-Prot

O89109, Q3U1J8, Q9CY39

Related

ENSMUSP00000146012.2, ENSMUST00000205428.2

Conserved Domains (3) summary

smart01053
Location:302 → 374

CaMBD; Calmodulin binding domain

pfam03530
Location:15 → 121

SK_channel; Calcium-activated SK potassium channel

pfam07885
Location:235 → 288

Ion_trans_2; Ion channel