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Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 [ Mus musculus (house mouse) ]

Gene ID: 16516, updated on 18-Sep-2024

Summary

Official Symbol
Kcnj15provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 15provided by MGI
Primary source
MGI:MGI:1310000
See related
Ensembl:ENSMUSG00000062609 AllianceGenome:MGI:1310000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IRKK; Kir4.2; 4930414N08Rik
Summary
Enables potassium channel activity. Acts upstream of or within potassium ion transport. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to human KCNJ15 (potassium inwardly rectifying channel subfamily J member 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 32.3), lung adult (RPKM 4.3) and 2 other tissues See more
Orthologs
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Genomic context

See Kcnj15 in Genome Data Viewer
Location:
16 C4; 16 55.86 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (95058417..95101119)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (95257558..95300260)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41599 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene predicted gene, 31641 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:95484660-95484843 Neighboring gene predicted gene, 31754 Neighboring gene STARR-positive B cell enhancer mm9_chr16:95563080-95563380 Neighboring gene STARR-positive B cell enhancer mm9_chr16:95572113-95572413 Neighboring gene STARR-positive B cell enhancer mm9_chr16:95581838-95582139 Neighboring gene STARR-positive B cell enhancer mm9_chr16:95649181-95649482 Neighboring gene STARR-positive B cell enhancer mm9_chr16:95650074-95650374 Neighboring gene ETS transcription factor Neighboring gene STARR-seq mESC enhancer starr_41600 Neighboring gene STARR-seq mESC enhancer starr_41602 Neighboring gene predicted gene, 31845

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IC
Inferred by Curator
more info
PubMed 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ATP-sensitive inward rectifier potassium channel 15
Names
inward rectifier K+ channel Kir4.2
potassium channel, inwardly rectifying subfamily J member 15

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039056.2NP_001034145.1  ATP-sensitive inward rectifier potassium channel 15 isoform b

    See identical proteins and their annotated locations for NP_001034145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 5, 7, 9 and 11 encode the same isoform (b).
    Source sequence(s)
    AC154691, AK165436
    Consensus CDS
    CCDS37410.1
    UniProtKB/Swiss-Prot
    O88932, Q9JK34
    UniProtKB/TrEMBL
    Q3TR79, Q53Z04
    Related
    ENSMUSP00000109485.2, ENSMUST00000113854.8
    Conserved Domains (2) summary
    pfam01007
    Location:30171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178349
    IRK_C; Inward rectifier potassium channel C-terminal domain
  2. NM_001039057.2NP_001034146.1  ATP-sensitive inward rectifier potassium channel 15 isoform a

    See identical proteins and their annotated locations for NP_001034146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1, 4, 6, 8, and 10 encode the same isoform (a).
    Source sequence(s)
    AC154691, AI116801, AK165436
    Consensus CDS
    CCDS28351.1
    UniProtKB/TrEMBL
    B7ZNJ9, Q3TNE6, Q3TR79, Q3UQ02
    Related
    ENSMUSP00000045218.8, ENSMUST00000037154.14
    Conserved Domains (2) summary
    pfam01007
    Location:57198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205376
    IRK_C; Inward rectifier potassium channel C-terminal domain
  3. NM_001271687.1NP_001258616.1  ATP-sensitive inward rectifier potassium channel 15 isoform a

    See identical proteins and their annotated locations for NP_001258616.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4, 6, 8, and 10 encode the same isoform (a).
    Source sequence(s)
    AC154691, AI891955, AK165436
    Consensus CDS
    CCDS28351.1
    UniProtKB/TrEMBL
    B7ZNJ9, Q3TNE6, Q3TR79, Q3UQ02
    Conserved Domains (2) summary
    pfam01007
    Location:57198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205376
    IRK_C; Inward rectifier potassium channel C-terminal domain
  4. NM_001271689.1NP_001258618.1  ATP-sensitive inward rectifier potassium channel 15 isoform b

    See identical proteins and their annotated locations for NP_001258618.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 5, 7, 9 and 11 encode the same isoform (b).
    Source sequence(s)
    AC154546, AC154691
    Consensus CDS
    CCDS37410.1
    UniProtKB/Swiss-Prot
    O88932, Q9JK34
    UniProtKB/TrEMBL
    Q3TR79, Q53Z04
    Related
    ENSMUSP00000109486.2, ENSMUST00000113855.8
    Conserved Domains (2) summary
    pfam01007
    Location:30171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178349
    IRK_C; Inward rectifier potassium channel C-terminal domain
  5. NM_001271690.1NP_001258619.1  ATP-sensitive inward rectifier potassium channel 15 isoform a

    See identical proteins and their annotated locations for NP_001258619.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 4, 6, 8, and 10 encode the same isoform (a).
    Source sequence(s)
    AC154691, AK165346, AK165436
    Consensus CDS
    CCDS28351.1
    UniProtKB/TrEMBL
    B7ZNJ9, Q3TNE6, Q3TR79, Q3UQ02
    Related
    ENSMUSP00000109492.2, ENSMUST00000113861.8
    Conserved Domains (2) summary
    pfam01007
    Location:57198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205376
    IRK_C; Inward rectifier potassium channel C-terminal domain
  6. NM_001271691.1NP_001258620.1  ATP-sensitive inward rectifier potassium channel 15 isoform b

    See identical proteins and their annotated locations for NP_001258620.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 5, 7, 9 and 11 encode the same isoform (b).
    Source sequence(s)
    AC154691, AK165436, AW012236
    Consensus CDS
    CCDS37410.1
    UniProtKB/Swiss-Prot
    O88932, Q9JK34
    UniProtKB/TrEMBL
    Q3TR79, Q53Z04
    Conserved Domains (2) summary
    pfam01007
    Location:30171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178349
    IRK_C; Inward rectifier potassium channel C-terminal domain
  7. NM_001271692.1NP_001258621.1  ATP-sensitive inward rectifier potassium channel 15 isoform a

    See identical proteins and their annotated locations for NP_001258621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1, 4, 6, 8, and 10 encode the same isoform (a).
    Source sequence(s)
    AC154546, AC154691
    Consensus CDS
    CCDS28351.1
    UniProtKB/TrEMBL
    B7ZNJ9, Q3TNE6, Q3TR79, Q3UQ02
    Conserved Domains (2) summary
    pfam01007
    Location:57198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205376
    IRK_C; Inward rectifier potassium channel C-terminal domain
  8. NM_001271693.1NP_001258622.1  ATP-sensitive inward rectifier potassium channel 15 isoform b

    See identical proteins and their annotated locations for NP_001258622.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 5, 7, 9 and 11 encode the same isoform (b).
    Source sequence(s)
    AC154691, AK165436, AW258994, AY377988
    Consensus CDS
    CCDS37410.1
    UniProtKB/Swiss-Prot
    O88932, Q9JK34
    UniProtKB/TrEMBL
    Q3TR79, Q53Z04
    Conserved Domains (2) summary
    pfam01007
    Location:30171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178349
    IRK_C; Inward rectifier potassium channel C-terminal domain
  9. NM_001271694.1NP_001258623.1  ATP-sensitive inward rectifier potassium channel 15 isoform a

    See identical proteins and their annotated locations for NP_001258623.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1, 4, 6, 8, and 10 encode the same isoform (a).
    Source sequence(s)
    AC154691, AK165436, AW319416
    Consensus CDS
    CCDS28351.1
    UniProtKB/TrEMBL
    B7ZNJ9, Q3TNE6, Q3TR79, Q3UQ02
    Conserved Domains (2) summary
    pfam01007
    Location:57198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205376
    IRK_C; Inward rectifier potassium channel C-terminal domain
  10. NM_001271695.1NP_001258624.1  ATP-sensitive inward rectifier potassium channel 15 isoform b

    See identical proteins and their annotated locations for NP_001258624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 5, 7, 9 and 11 encode the same isoform (b).
    Source sequence(s)
    AC154691, AI891955, AK165436, BB843850
    Consensus CDS
    CCDS37410.1
    UniProtKB/Swiss-Prot
    O88932, Q9JK34
    UniProtKB/TrEMBL
    Q3TR79, Q53Z04
    Conserved Domains (2) summary
    pfam01007
    Location:30171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178349
    IRK_C; Inward rectifier potassium channel C-terminal domain
  11. NM_019664.5NP_062638.1  ATP-sensitive inward rectifier potassium channel 15 isoform b

    See identical proteins and their annotated locations for NP_062638.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 5, 7, 9 and 11 encode the same isoform (b).
    Source sequence(s)
    AC154691, AK165436, AW260030, AY377988
    Consensus CDS
    CCDS37410.1
    UniProtKB/Swiss-Prot
    O88932, Q9JK34
    UniProtKB/TrEMBL
    Q3TR79, Q53Z04
    Related
    ENSMUSP00000109487.2, ENSMUST00000113856.8
    Conserved Domains (2) summary
    pfam01007
    Location:30171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178349
    IRK_C; Inward rectifier potassium channel C-terminal domain

RNA

  1. NR_073406.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) uses an alternate splice site and two alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC154546, AC154691

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    95058417..95101119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522944.3XP_006523007.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    See identical proteins and their annotated locations for XP_006523007.1

    UniProtKB/TrEMBL
    B7ZNJ9, Q3TNE6, Q3TR79, Q3UQ02
    Related
    ENSMUSP00000109493.2, ENSMUST00000113862.8
    Conserved Domains (2) summary
    pfam01007
    Location:57198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205376
    IRK_C; Inward rectifier potassium channel C-terminal domain
  2. XM_006522951.4XP_006523014.1  ATP-sensitive inward rectifier potassium channel 15 isoform X3

    See identical proteins and their annotated locations for XP_006523014.1

    UniProtKB/Swiss-Prot
    O88932, Q9JK34
    UniProtKB/TrEMBL
    Q3TR79, Q53Z04
    Conserved Domains (2) summary
    pfam01007
    Location:30171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178349
    IRK_C; Inward rectifier potassium channel C-terminal domain
  3. XM_006522942.4XP_006523005.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    See identical proteins and their annotated locations for XP_006523005.1

    UniProtKB/TrEMBL
    B7ZNJ9, Q3TNE6, Q3TR79, Q3UQ02
    Conserved Domains (2) summary
    pfam01007
    Location:57198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205376
    IRK_C; Inward rectifier potassium channel C-terminal domain
  4. XM_006522950.4XP_006523013.1  ATP-sensitive inward rectifier potassium channel 15 isoform X2

    See identical proteins and their annotated locations for XP_006523013.1

    UniProtKB/TrEMBL
    Q3TR79
    Conserved Domains (2) summary
    pfam01007
    Location:46187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194365
    IRK_C; Inward rectifier potassium channel C-terminal domain
  5. XM_006522945.4XP_006523008.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    See identical proteins and their annotated locations for XP_006523008.1

    UniProtKB/TrEMBL
    B7ZNJ9, Q3TNE6, Q3TR79, Q3UQ02
    Conserved Domains (2) summary
    pfam01007
    Location:57198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205376
    IRK_C; Inward rectifier potassium channel C-terminal domain
  6. XM_017316883.2XP_017172372.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    UniProtKB/TrEMBL
    B7ZNJ9, Q3TNE6, Q3TR79, Q3UQ02
    Related
    ENSMUSP00000109490.2, ENSMUST00000113859.8
    Conserved Domains (2) summary
    pfam01007
    Location:57198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205376
    IRK_C; Inward rectifier potassium channel C-terminal domain
  7. XM_017316885.1XP_017172374.1  ATP-sensitive inward rectifier potassium channel 15 isoform X3

    UniProtKB/Swiss-Prot
    O88932, Q9JK34
    UniProtKB/TrEMBL
    Q3TR79, Q53Z04
    Related
    ENSMUSP00000109489.3, ENSMUST00000113858.3
    Conserved Domains (2) summary
    pfam01007
    Location:30171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178349
    IRK_C; Inward rectifier potassium channel C-terminal domain
  8. XM_036159796.1XP_036015689.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    UniProtKB/TrEMBL
    B7ZNJ9, Q3TNE6, Q3TR79, Q3UQ02
    Conserved Domains (2) summary
    pfam01007
    Location:57198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205376
    IRK_C; Inward rectifier potassium channel C-terminal domain
  9. XM_017316884.1XP_017172373.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    UniProtKB/TrEMBL
    B7ZNJ9, Q3TNE6, Q3TR79, Q3UQ02
    Conserved Domains (2) summary
    pfam01007
    Location:57198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205376
    IRK_C; Inward rectifier potassium channel C-terminal domain
  10. XM_006522947.3XP_006523010.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    See identical proteins and their annotated locations for XP_006523010.1

    UniProtKB/TrEMBL
    B7ZNJ9, Q3TNE6, Q3TR79, Q3UQ02
    Conserved Domains (2) summary
    pfam01007
    Location:57198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205376
    IRK_C; Inward rectifier potassium channel C-terminal domain
  11. XM_006522946.4XP_006523009.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    See identical proteins and their annotated locations for XP_006523009.1

    UniProtKB/TrEMBL
    B7ZNJ9, Q3TNE6, Q3TR79, Q3UQ02
    Conserved Domains (2) summary
    pfam01007
    Location:57198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205376
    IRK_C; Inward rectifier potassium channel C-terminal domain
  12. XM_006522952.5XP_006523015.1  ATP-sensitive inward rectifier potassium channel 15 isoform X3

    See identical proteins and their annotated locations for XP_006523015.1

    UniProtKB/Swiss-Prot
    O88932, Q9JK34
    UniProtKB/TrEMBL
    Q3TR79, Q53Z04
    Conserved Domains (2) summary
    pfam01007
    Location:30171
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:178349
    IRK_C; Inward rectifier potassium channel C-terminal domain