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ADGRF3 adhesion G protein-coupled receptor F3 [ Homo sapiens (human) ]

Gene ID: 165082, updated on 7-Apr-2024

Summary

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Official Symbol
ADGRF3provided by HGNC
Official Full Name
adhesion G protein-coupled receptor F3provided by HGNC
Primary source
HGNC:HGNC:18989
See related
Ensembl:ENSG00000173567 AllianceGenome:HGNC:18989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR23; GPR113
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
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Genomic context

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Location:
2p23.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (26308173..26346789, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (26343551..26385469, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (26531041..26569657, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene GRB2 associated regulator of MAPK1 subtype 2 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26465316-26465856 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26467342-26468022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26468835-26469562 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Neighboring gene uncharacterized LOC105374334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26536028-26536873 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26540931-26541430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15470 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26568936-26569703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15471 Neighboring gene selenoprotein I Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15472 Neighboring gene dynein regulatory complex subunit 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26681071-26681640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26680500-26681070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26683329-26684034 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:26685720-26686919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26703326-26703826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26704893-26705698 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:26712674-26712916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15474 Neighboring gene otoferlin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26728504-26729004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26734217-26735140 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:26744163-26744328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26759696-26760624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26760625-26761553 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26765926-26766660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26780985-26781778

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Overexpression of membrane proteins in primary and metastatic gastrointestinal neuroendocrine tumors. Carr JC, et al. Ann Surg Oncol, 2013 Dec. PMID 24114056, Free PMC Article
  2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. Fredriksson R, et al. FEBS Lett, 2002 Nov 20. PMID 12435584
  3. Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics. Crockett DK, et al. Proteomics, 2005 Apr. PMID 15717329
  4. Identification of G protein-coupled receptor genes from the human genome sequence. Takeda S, et al. FEBS Lett, 2002 Jun 5. PMID 12044878
  5. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of GPR113 is associated with Small bowel primary and metastatic neuroendocrine tumors.
    Title: Overexpression of membrane proteins in primary and metastatic gastrointestinal neuroendocrine tumors.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16767

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adhesion G-protein coupled receptor F3
Names
G protein-coupled receptor 113
G protein-coupled receptor PGR23
probable G-protein coupled receptor 113
seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145168.1 → NP_001138640.1  adhesion G-protein coupled receptor F3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001138640.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC010896, AY140955
    Consensus CDS
    CCDS46239.1
    UniProtKB/Swiss-Prot
    B4DF15, E9PEV1, Q53TA5, Q6UXT7, Q6UXX3, Q86SL7, Q8IXD8, Q8IZF5, Q8TDT3
    Related
    ENSP00000307831.1, ENST00000311519.5
    Conserved Domains (3) summary
    pfam01825
    Location:713 → 758
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:431 → 477
    HRM; Hormone receptor domain
    cl21561
    Location:770 → 1016
    7tm_4; Olfactory receptor

  2. NM_001145169.1 → NP_001138641.1  adhesion G-protein coupled receptor F3 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has alternate 5' and 3' sequences, as compared to variant 1. The resulting isoform (2) lacks an internal segment in the N-terminal region and has a shorter and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AA459569, AK293887, AY140955, BC043211
    Consensus CDS
    CCDS46238.1
    UniProtKB/Swiss-Prot
    Q8IZF5
    Related
    ENSP00000388537.2, ENST00000421160.6
    Conserved Domains (3) summary
    cd15253
    Location:698 → 968
    7tmB2_GPR113; orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:362 → 408
    HRM; Hormone receptor domain
    pfam01825
    Location:644 → 689
    GPS; GPCR proteolysis site, GPS, motif

  3. NM_001321971.2 → NP_001308900.1  adhesion G-protein coupled receptor F3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC010896, AK293887, AY358172, BC043211
    Consensus CDS
    CCDS92721.1
    UniProtKB/TrEMBL
    A0A494C083
    Related
    ENSP00000498434.1, ENST00000651242.2
    Conserved Domains (3) summary
    pfam01825
    Location:645 → 690
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:363 → 409
    HRM; Hormone receptor domain
    cl21561
    Location:702 → 948
    7tm_4; Olfactory receptor

  4. NM_001321975.2 → NP_001308904.1  adhesion G-protein coupled receptor F3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC010896, AY140955, BC043211, HY209981
    UniProtKB/TrEMBL
    B3KVM9
    Related
    ENST00000459892.5
    Conserved Domains (3) summary
    cd15253
    Location:370 → 640
    7tmB2_GPR113; orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:316 → 361
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:34 → 80
    HRM; Hormone receptor domain

  5. NM_001393343.1 → NP_001380272.1  adhesion G-protein coupled receptor F3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC010896
    UniProtKB/TrEMBL
    B3KVM9
    Conserved Domains (3) summary
    cd15253
    Location:370 → 640
    7tmB2_GPR113; orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:316 → 361
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:34 → 80
    HRM; Hormone receptor domain

  6. NM_153835.4 → NP_722577.2  adhesion G-protein coupled receptor F3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has alternate 5' and 3' sequences and lacks two internal in-frame coding exons, as compared to variant 1. The resulting isoform (3) has shorter and different N- and C-termini and lack an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC010896, AY358172, BC043211
    Consensus CDS
    CCDS33159.2
    UniProtKB/Swiss-Prot
    Q8IZF5
    Related
    ENSP00000327396.6, ENST00000333478.10
    Conserved Domains (3) summary
    pfam01825
    Location:514 → 559
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:232 → 278
    HRM; Hormone receptor domain
    cl21561
    Location:571 → 817
    7tm_4; Olfactory receptor

RNA

  1. NR_135916.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AY140955, AY358172, BC043211
    Related
    ENST00000435303.1

  2. NR_171656.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010896

  3. NR_171657.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010896

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    26308173..26346789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443563.1 → XP_047299519.1  adhesion G-protein coupled receptor F3 isoform X2

  2. XM_011532621.4 → XP_011530923.1  adhesion G-protein coupled receptor F3 isoform X1

    Conserved Domains (3) summary
    pfam01825
    Location:654 → 699
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:372 → 418
    HRM; Hormone receptor domain
    cl21561
    Location:711 → 957
    7tm_4; Olfactory receptor

  3. XM_047443565.1 → XP_047299521.1  adhesion G-protein coupled receptor F3 isoform X5

  4. XM_011532622.3 → XP_011530924.1  adhesion G-protein coupled receptor F3 isoform X3

    Conserved Domains (3) summary
    pfam01825
    Location:644 → 689
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:362 → 408
    HRM; Hormone receptor domain
    cl21561
    Location:701 → 947
    7tm_4; Olfactory receptor

  5. XM_047443564.1 → XP_047299520.1  adhesion G-protein coupled receptor F3 isoform X4

  6. XM_011532623.3 → XP_011530925.1  adhesion G-protein coupled receptor F3 isoform X4

    See identical proteins and their annotated locations for XP_011530925.1

    Conserved Domains (3) summary
    pfam01825
    Location:638 → 683
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:356 → 402
    HRM; Hormone receptor domain
    cl21561
    Location:695 → 941
    7tm_4; Olfactory receptor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    26343551..26385469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340854.1 → XP_054196829.1  adhesion G-protein coupled receptor F3 isoform X6

  2. XM_054340855.1 → XP_054196830.1  adhesion G-protein coupled receptor F3 isoform X5

  3. XM_054340850.1 → XP_054196825.1  adhesion G-protein coupled receptor F3 isoform X2

  4. XM_054340849.1 → XP_054196824.1  adhesion G-protein coupled receptor F3 isoform X1

  5. XM_054340851.1 → XP_054196826.1  adhesion G-protein coupled receptor F3 isoform X3

  6. XM_054340853.1 → XP_054196828.1  adhesion G-protein coupled receptor F3 isoform X4

  7. XM_054340852.1 → XP_054196827.1  adhesion G-protein coupled receptor F3 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZF5.1 GenPept UniProtKB/Swiss-Prot:Q8IZF5

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