Itih2 inter-alpha trypsin inhibitor, heavy chain 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itih2provided by MGI
Official Full Name: inter-alpha trypsin inhibitor, heavy chain 2provided by MGI
Primary source: MGI:MGI:96619
See related: Ensembl:ENSMUSG00000037254 AllianceGenome:MGI:96619
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Intin2; Itih-2; ITI-HC2
Summary: Predicted to enable hyaluronic acid binding activity. Predicted to be involved in hyaluronan metabolic process and negative regulation of peptidase activity. Located in collagen-containing extracellular matrix. Is expressed in germ cell of testis; gut; liver; and meninges. Orthologous to human ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver E18 (RPKM 372.8), liver E14 (RPKM 211.7) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A1; 2 6.89 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (10099408..10135492, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (10094591..10130683, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Mit4 (e-PCR), detects polymorphism
- UniSTS:129303

AI747202 (e-PCR)
- UniSTS:178565

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in hyaluronan metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inter-alpha-trypsin inhibitor heavy chain H2

Names: ITI heavy chain H2; inter-alpha-inhibitor heavy chain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010582.4 → NP_034712.3 inter-alpha-trypsin inhibitor heavy chain H2 precursor

Status: VALIDATED

Source sequence(s)

AL772367

Consensus CDS

CCDS15677.2

UniProtKB/Swiss-Prot

A2AKU6, Q3UZM0, Q61703

Related

ENSMUSP00000046530.9, ENSMUST00000042290.14

Conserved Domains (3) summary

smart00609
Location:56 → 185

VIT; Vault protein Inter-alpha-Trypsin domain

cd01461
Location:307 → 488

vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...

pfam06668
Location:735 → 921

ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus