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DCN decorin [ Homo sapiens (human) ]

Gene ID: 1634, updated on 23-Mar-2024

Summary

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Official Symbol
DCNprovided by HGNC
Official Full Name
decorinprovided by HGNC
Primary source
HGNC:HGNC:2705
See related
Ensembl:ENSG00000011465 MIM:125255; AllianceGenome:HGNC:2705
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B
Summary
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
Expression
Broad expression in ovary (RPKM 562.9), gall bladder (RPKM 411.1) and 18 other tissues See more
Orthologs
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Genomic context

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Location:
12q21.33
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (91140484..91182817, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (91117966..91160293, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (91534261..91576594, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratocan Neighboring gene VISTA enhancer hs2540 Neighboring gene lumican Neighboring gene uncharacterized LOC124903075 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:91666219-91666772 Neighboring gene uncharacterized LOC105369896 Neighboring gene uncharacterized LOC107984544

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. HBx downregulated decorin and decorin-derived peptides inhibit the proliferation and tumorigenicity of hepatocellular carcinoma cells. Li Y, et al. FASEB J, 2023 Apr. PMID 36929160
  2. Study on the expression profile and role of decorin in the progression of pancreatic cancer. Zhang L, et al. Aging (Albany NY), 2021 May 21. PMID 34021540, Free PMC Article
  3. Cardioprotective Effect of Decorin in Type 2 Diabetes. Chen F, et al. Front Endocrinol (Lausanne), 2020. PMID 33365011, Free PMC Article
  4. Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans. Wong TH, et al. Aging (Albany NY), 2020 Nov 26. PMID 33257596, Free PMC Article
  5. Decorin in the Tumor Microenvironment. Baghy K, et al. Adv Exp Med Biol, 2020. PMID 32845500

See all (262) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The effects of TGF-beta1 and IFN-alpha2b on decorin, decorin isoforms and type I collagen in hypertrophic scar dermal fibroblasts.
    Title: The effects of TGF-β1 and IFN-α2b on decorin, decorin isoforms and type I collagen in hypertrophic scar dermal fibroblasts.
  2. Maternally Expressed Gene 3 Negatively Regulated Decorin to Supresse Angiogenesis, Proliferation and Migration of Endothelial Cells.
    Title: Maternally Expressed Gene 3 Negatively Regulated Decorin to Supresse Angiogenesis, Proliferation and Migration of Endothelial Cells.
  3. The aberrant levels of decorin induce damages of human salivary gland epithelial cells and polarization of macrophages.
    Title: The aberrant levels of decorin induce damages of human salivary gland epithelial cells and polarization of macrophages.
  4. HBx downregulated decorin and decorin-derived peptides inhibit the proliferation and tumorigenicity of hepatocellular carcinoma cells.
    Title: HBx downregulated decorin and decorin-derived peptides inhibit the proliferation and tumorigenicity of hepatocellular carcinoma cells.
  5. The levels of peripheral blood TNF-alpha, Decorin and neutrophils MAPK1 mRNA levels of patients with preeclampsia and their clinical significance.
    Title: The levels of peripheral blood TNF-α, Decorin and neutrophils MAPK1 mRNA levels of patients with preeclampsia and their clinical significance.
  6. Resistance Exercise-Induced Increases in Muscle Myostatin mRNA and Protein Expression Are Subsequently Decreased in Circulation in the Presence of Increased Levels of the Extracellular Matrix Stabilizing Protein Decorin.
    Title: Resistance Exercise-Induced Increases in Muscle Myostatin mRNA and Protein Expression Are Subsequently Decreased in Circulation in the Presence of Increased Levels of the Extracellular Matrix Stabilizing Protein Decorin.
  7. Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss.
    Title: Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss.
  8. Serum Decorin, Biglycan, and Extracellular Matrix Component Expression in Preterm Birth.
    Title: Serum Decorin, Biglycan, and Extracellular Matrix Component Expression in Preterm Birth.
  9. Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases.
    Title: Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases.
  10. A novel ocular function for decorin in the aqueous humor outflow.
    Title: A novel ocular function for decorin in the aqueous humor outflow.
Submit: New GeneRIF Correction See all GeneRIFs (189)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Congenital stromal corneal dystrophy
MedGen: C1864738 OMIM: 610048 GeneReviews: Congenital Stromal Corneal Dystrophy
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EBI GWAS Catalog

Description
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables extracellular matrix binding IEA
Inferred from Electronic Annotation
more info
  
enables extracellular matrix structural constituent conferring compression resistance ISS
Inferred from Sequence or Structural Similarity
more info
  
enables extracellular matrix structural constituent conferring compression resistance RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables glycosaminoglycan binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of vascular endothelial growth factor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of macroautophagy IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of macroautophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of mitochondrial depolarization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of mitochondrial fission IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
  
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
colocalizes_with collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
decorin
Names
bone proteoglycan II
dermatan sulphate proteoglycans II
proteoglycan core protein
small leucine-rich protein 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011672.2 RefSeqGene

    Range
    5000..47333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001920.5 → NP_001911.1  decorin isoform a preproprotein

    See identical proteins and their annotated locations for NP_001911.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A1) represents the longest transcript and encodes the longest isoform. Both variants A1 and A2 encode the same isoform (a).
    Source sequence(s)
    AC007115, AW444736, BM672011, BX094949, BX571756, CD689331
    Consensus CDS
    CCDS9039.1
    UniProtKB/Swiss-Prot
    P07585, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9
    UniProtKB/TrEMBL
    Q6FH10
    Related
    ENSP00000052754.5, ENST00000052754.10
    Conserved Domains (3) summary
    sd00033
    Location:62 → 82
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01462
    Location:54 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    cl26018
    Location:70 → 298
    NEL; C-terminal novel E3 ligase, LRR-interacting

  2. NM_133503.4 → NP_598010.1  decorin isoform a preproprotein

    See identical proteins and their annotated locations for NP_598010.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A2) differs in the 5' UTR compared to variant A1. Both variants A1 and A2 encode the same isoform (a).
    Source sequence(s)
    AC007115, AW444736, BM672011, BX094949, BX571756
    Consensus CDS
    CCDS9039.1
    UniProtKB/Swiss-Prot
    P07585, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9
    UniProtKB/TrEMBL
    Q6FH10
    Conserved Domains (3) summary
    sd00033
    Location:62 → 82
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01462
    Location:54 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    cl26018
    Location:70 → 298
    NEL; C-terminal novel E3 ligase, LRR-interacting

  3. NM_133504.3 → NP_598011.1  decorin isoform b precursor

    See identical proteins and their annotated locations for NP_598011.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) differs in the 5' UTR and lacks two alternate exons in the coding region compared to variant A1. The encoded isoform (b) is shorter than isoform a. This isoform (b) may undergo proteolytic processing similar to isoform a.
    Source sequence(s)
    AC007115, AF138301, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244
    Consensus CDS
    CCDS9040.1
    UniProtKB/Swiss-Prot
    P07585
    UniProtKB/TrEMBL
    Q6FH10
    Related
    ENSP00000413723.2, ENST00000420120.6
    Conserved Domains (4) summary
    smart00013
    Location:54 → 77
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:70 → 92
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:112 → 172
    LRR_8; Leucine rich repeat
    cl26793
    Location:70 → 196
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

  4. NM_133505.3 → NP_598012.1  decorin isoform c precursor

    See identical proteins and their annotated locations for NP_598012.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) differs in the 5' UTR and lacks three alternate exons in the coding region compared to variant A1. The encoded isoform (c) is shorter than isoform a. This isoform (c) may undergo proteolytic processing similar to isoform a.
    Source sequence(s)
    AC007115, AF138302, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244
    Consensus CDS
    CCDS9041.1
    UniProtKB/TrEMBL
    F8VNV6
    Related
    ENSP00000401021.1, ENST00000425043.5
    Conserved Domains (3) summary
    smart00013
    Location:54 → 76
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:76 → 99
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:74 → 134
    LRR_8; Leucine rich repeat

  5. NM_133506.3 → NP_598013.1  decorin isoform d precursor

    See identical proteins and their annotated locations for NP_598013.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (D) differs in the 5' UTR and lacks four alternate exons in the coding region compared to variant A1. The encoded isoform (d) is shorter than isoform a. This isoform (d) may undergo proteolytic processing similar to isoform a.
    Source sequence(s)
    AC007115, AF138303, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244
    Consensus CDS
    CCDS9042.1
    UniProtKB/TrEMBL
    A0A0S2Z3L8
    Related
    ENSP00000399815.2, ENST00000441303.6
    Conserved Domains (3) summary
    smart00013
    Location:54 → 85
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:62 → 82
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:84 → 125
    LRR_8; Leucine rich repeat

  6. NM_133507.3 → NP_598014.1  decorin isoform e precursor

    See identical proteins and their annotated locations for NP_598014.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (E) differs in the 5' UTR and lacks five alternate exons in the coding region compared to variant A1. The encoded isoform (e) is shorter than isoform a. This isoform (e) may undergo proteolytic processing similar to isoform a.
    Source sequence(s)
    AC007115, AF138304, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244
    Consensus CDS
    CCDS44951.1
    UniProtKB/TrEMBL
    A0A7I2PRI8
    Related
    ENSP00000398514.2, ENST00000456569.2
    Conserved Domains (1) summary
    cl02423
    Location:54 → 71
    LRRNT; Leucine rich repeat N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    91140484..91182817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    91117966..91160293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07585.1 GenPept UniProtKB/Swiss-Prot:P07585

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