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TMEM92 transmembrane protein 92 [ Homo sapiens (human) ]

Gene ID: 162461, updated on 5-Mar-2024

Summary

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Official Symbol
TMEM92provided by HGNC
Official Full Name
transmembrane protein 92provided by HGNC
Primary source
HGNC:HGNC:26579
See related
Ensembl:ENSG00000167105 MIM:619604; AllianceGenome:HGNC:26579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine (RPKM 10.1), duodenum (RPKM 7.9) and 7 other tissues See more
Orthologs
all
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Genomic context

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Location:
17q21.33
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (50271406..50281485)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (51138488..51148563)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48348767..48358846)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48335091-48335661 Neighboring gene uncharacterized LOC124904028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8692 Neighboring gene Sharpr-MPRA regulatory region 4171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48354331-48354878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:48354879-48355426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8693 Neighboring gene TMEM92 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr17:48380397-48381379 Neighboring gene NANOG hESC enhancer GRCh37_chr17:48388769-48389287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12381 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:48395384-48395963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48395964-48396542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8695 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8696 Neighboring gene Sharpr-MPRA regulatory region 10047 Neighboring gene xylosyltransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Transmembrane protein 92 performs a tumor-promoting function in breast carcinoma by contributing to the cell growth, invasion, migration and epithelial-mesenchymal transition. Lin MZ, et al. Tissue Cell, 2020 Dec. PMID 32835947
  2. A prognostic 4-gene expression signature for squamous cell lung carcinoma. Li J, et al. J Cell Physiol, 2017 Dec. PMID 28160492
  3. MiR-23a/-24-induced gene silencing results in mesothelial cell integration of pancreatic cancer. Listing H, et al. Br J Cancer, 2015 Jan 6. PMID 25422915, Free PMC Article
  4. Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families. Alazami AM, et al. Cell Rep, 2015 Jan 13. PMID 25558065
  5. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. Pei J, et al. Cell Signal, 2012 Mar. PMID 22120523, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transmembrane protein 92 performs a tumor-promoting function in breast carcinoma by contributing to the cell growth, invasion, migration and epithelial-mesenchymal transition.
    Title: Transmembrane protein 92 performs a tumor-promoting function in breast carcinoma by contributing to the cell growth, invasion, migration and epithelial-mesenchymal transition.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ33318

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
transmembrane protein 92

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054733.1 RefSeqGene

    Range
    8061..15080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001168215.2 → NP_001161687.1  transmembrane protein 92 precursor

    See identical proteins and their annotated locations for NP_001161687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC015909, AK090637, AW293202, AY358204
    Consensus CDS
    CCDS11562.1
    UniProtKB/Swiss-Prot
    Q6UXU6, Q8NBF0
    Related
    ENSP00000300433.3, ENST00000300433.7
    Conserved Domains (1) summary
    pfam11669
    Location:34 → 127
    WBP-1; WW domain-binding protein 1

  2. NM_153229.3 → NP_694961.2  transmembrane protein 92 precursor

    See identical proteins and their annotated locations for NP_694961.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC015909, AK090637, AW293202, DB072318
    Consensus CDS
    CCDS11562.1
    UniProtKB/Swiss-Prot
    Q6UXU6, Q8NBF0
    Related
    ENSP00000425144.1, ENST00000507382.2
    Conserved Domains (1) summary
    pfam11669
    Location:34 → 127
    WBP-1; WW domain-binding protein 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    50271406..50281485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    51138488..51148563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UXU6.1 GenPept UniProtKB/Swiss-Prot:Q6UXU6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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