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DGKQ diacylglycerol kinase theta [ Homo sapiens (human) ]

Gene ID: 1609, updated on 14-Nov-2024

Summary

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Official Symbol
DGKQprovided by HGNC
Official Full Name
diacylglycerol kinase thetaprovided by HGNC
Primary source
HGNC:HGNC:2856
See related
Ensembl:ENSG00000145214 MIM:601207; AllianceGenome:HGNC:2856
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAGK; DAGK4; DAGK7
Summary
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in small intestine (RPKM 9.9), duodenum (RPKM 8.3) and 25 other tissues See more
Orthologs
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Genomic context

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See DGKQ in Genome Data Viewer
Location:
4p16.3
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (958887..973569, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (956995..971678, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (952675..967357, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene cyclin G associated kinase Neighboring gene uncharacterized LOC105374341 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:872957-874156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:880593-881094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:881095-881594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:905677-906582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:906583-907488 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21140 Neighboring gene transmembrane protein 175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:938924-939517 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:957241-957400 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:961731-962444 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:962445-963158 Neighboring gene uncharacterized LOC124900645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:963506-964024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:965861-966501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:973450-974030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21142 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:981121-981298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:983059-983560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:983561-984060 Neighboring gene solute carrier family 26 member 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:986529-987340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:987341-988152 Neighboring gene uncharacterized LOC124900646 Neighboring gene alpha-L-iduronidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3. Endele S, et al. Genomics, 1996 Apr 1. PMID 8617502
  2. Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. Houssa B, et al. J Biol Chem, 1997 Apr 18. PMID 9099683
  3. Negative regulation of diacylglycerol kinase theta mediates adenosine-dependent hepatocyte preconditioning. Baldanzi G, et al. Cell Death Differ, 2010 Jun. PMID 20057501
  4. Silencing diacylglycerol kinase-theta expression reduces steroid hormone biosynthesis and cholesterol metabolism in human adrenocortical cells. Cai K, et al. Biochim Biophys Acta, 2014 Apr 4. PMID 24369117, Free PMC Article
  5. GAK rs1564282 and DGKQ rs11248060 increase the risk for Parkinson's disease in a Chinese population. Chen YP, et al. J Clin Neurosci, 2013 Jun. PMID 23618683

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association study of MCCC1/LAMP3 and DGKQ variants with Parkinson's disease in patients of Malay ancestry.
    Title: Association study of MCCC1/LAMP3 and DGKQ variants with Parkinson's disease in patients of Malay ancestry.
  2. Roles of DGKs in neurons: Postsynaptic functions?
    Title: Roles of DGKs in neurons: Postsynaptic functions?
  3. these data demonstrate that DGKtheta; plays an important role in steroid hormone production in human adrenocortical cells
    Title: Silencing diacylglycerol kinase-theta expression reduces steroid hormone biosynthesis and cholesterol metabolism in human adrenocortical cells.
  4. The SF1 and SREBP1 activate DGKtheta; transcription in a cAMP-dependent manner in human adrenocortical cells.
    Title: cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1.
  5. This study found that the minor alleles of GAK rs1564282 and DGKQ rs11248060 significantly increase the risk of PD in Han Chinese populations.
    Title: GAK rs1564282 and DGKQ rs11248060 increase the risk for Parkinson's disease in a Chinese population.
  6. Data suggest that diacylglycerol kinase theta is a key mediator of bile-acid-stimulated modulation of farnesoid X receptor/mTOR complex 2/Akt signaling pathway and glucose metabolism/homoeostasis in hepatocytes.
    Title: Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes.
  7. DGKtheta; translocation and activity is regulated by the concerted activity of EGFR and PKC.
    Title: Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor.
  8. DGK-theta; directly interacts with, and is activated by, basic proteins such as histone H1 and Tau with nm affinity, consistent with a potential role for a polybasic protein or protein domain in the activation of this enzyme.
    Title: Dual regulation of diacylglycerol kinase (DGK)-θ: polybasic proteins promote activation by phospholipids and increase substrate affinity.
  9. Data show that cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17.
    Title: Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17.
  10. Nuclear DGK-theta co-localizes with phosphatidylinositol 4,5-bisphosphate (PIP(2)) in domains that correspond to nuclear speckles.
    Title: Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
EBI GWAS Catalog
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
EBI GWAS Catalog
Genomewide association study for susceptibility genes contributing to familial Parkinson disease.
EBI GWAS Catalog
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
EBI GWAS Catalog
Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent diacylglycerol kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP-dependent diacylglycerol kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP-dependent diacylglycerol kinase activity TAS
Traceable Author Statement
more info
  
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables alkylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to bile acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in diacylglycerol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycerolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerolipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of peptidyl-threonine phosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in platelet activation TAS
Traceable Author Statement
more info
  
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cortisol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of progesterone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to cAMP IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in thrombin-activated receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
diacylglycerol kinase theta
Names
DAG kinase theta
DGK-theta
DGKtheta
diacylglycerol kinase, theta 110kDa
diglyceride kinase theta
testis tissue sperm-binding protein Li 38a
NP_001338.2
XP_011511713.1
XP_011511714.1
XP_011511716.1
XP_011511717.1
XP_047305643.1
XP_047305644.1
XP_054205037.1
XP_054205038.1
XP_054205039.1
XP_054205040.1
XP_054205041.1
XP_054205042.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347.4 → NP_001338.2  diacylglycerol kinase theta

    See identical proteins and their annotated locations for NP_001338.2

    Status: REVIEWED

    Source sequence(s)
    AB209503, AC019103, BC063801, DN990411
    Consensus CDS
    CCDS3342.1
    UniProtKB/Swiss-Prot
    P52824, Q6P3W4
    UniProtKB/TrEMBL
    A0A140VKC1, E9KL49
    Related
    ENSP00000273814.3, ENST00000273814.8
    Conserved Domains (6) summary
    cd01783
    Location:395 → 492
    DAGK_delta_RA; Ubiquitin-like domain of Diacylgylcerol kinase (DAGK)
    smart00045
    Location:741 → 893
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:590 → 714
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:61 → 108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00040
    Location:122 → 169
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00155
    Location:296 → 348
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    958887..973569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513411.2 → XP_011511713.1  diacylglycerol kinase theta isoform X2

    UniProtKB/TrEMBL
    E9KL49
    Conserved Domains (5) summary
    smart00045
    Location:741 → 893
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:590 → 714
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:61 → 108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00040
    Location:122 → 169
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00155
    Location:395 → 475
    UBQ; Ubiquitin-like proteins

  2. XM_047449687.1 → XP_047305643.1  diacylglycerol kinase theta isoform X1

  3. XM_011513412.2 → XP_011511714.1  diacylglycerol kinase theta isoform X3

    Conserved Domains (5) summary
    cd01783
    Location:395 → 492
    DAGK_delta_RA; Ubiquitin-like domain of Diacylgylcerol kinase (DAGK)
    cd00029
    Location:61 → 108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00040
    Location:122 → 169
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00155
    Location:296 → 348
    UBQ; Ubiquitin-like proteins
    cl01255
    Location:590 → 629
    DAGK_cat; Diacylglycerol kinase catalytic domain

  4. XM_011513414.3 → XP_011511716.1  diacylglycerol kinase theta isoform X4

    See identical proteins and their annotated locations for XP_011511716.1

    Conserved Domains (4) summary
    cd01783
    Location:395 → 492
    DAGK_delta_RA; Ubiquitin-like domain of Diacylgylcerol kinase (DAGK)
    cd00029
    Location:61 → 108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00040
    Location:122 → 169
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00155
    Location:296 → 348
    UBQ; Ubiquitin-like proteins

  5. XM_047449688.1 → XP_047305644.1  diacylglycerol kinase theta isoform X4

  6. XM_011513415.2 → XP_011511717.1  diacylglycerol kinase theta isoform X5

    Conserved Domains (3) summary
    cd00029
    Location:61 → 108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00040
    Location:122 → 169
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl00155
    Location:395 → 481
    UBQ; Ubiquitin-like proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    956995..971678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349063.1 → XP_054205038.1  diacylglycerol kinase theta isoform X2

  2. XM_054349062.1 → XP_054205037.1  diacylglycerol kinase theta isoform X1

  3. XM_054349064.1 → XP_054205039.1  diacylglycerol kinase theta isoform X3

  4. XM_054349066.1 → XP_054205041.1  diacylglycerol kinase theta isoform X4

  5. XM_054349065.1 → XP_054205040.1  diacylglycerol kinase theta isoform X4

  6. XM_054349067.1 → XP_054205042.1  diacylglycerol kinase theta isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52824.2 GenPept UniProtKB/Swiss-Prot:P52824

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