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DGKB diacylglycerol kinase beta [ Homo sapiens (human) ]

Gene ID: 1607, updated on 11-Apr-2024

Summary

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Official Symbol
DGKBprovided by HGNC
Official Full Name
diacylglycerol kinase betaprovided by HGNC
Primary source
HGNC:HGNC:2850
See related
Ensembl:ENSG00000136267 MIM:604070; AllianceGenome:HGNC:2850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DGK; DAGK2; DGK-BETA
Summary
Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
Expression
Biased expression in brain (RPKM 7.2), adrenal (RPKM 0.9) and 2 other tissues See more
Orthologs
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Genomic context

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See DGKB in Genome Data Viewer
Location:
7p21.2
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (14145049..14974858, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (14277079..15107587, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (14184674..15014483, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene solute carrier family 34 member 2 pseudogene Neighboring gene uncharacterized LOC105375162 Neighboring gene NANOG hESC enhancer GRCh37_chr7:14104855-14105356 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:14119884-14121083 Neighboring gene MPRA-validated peak6403 silencer Neighboring gene ribosomal protein L6 pseudogene 21 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 26 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:14308715-14309214 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:14308213-14308714 Neighboring gene MPRA-validated peak6405 silencer Neighboring gene VISTA enhancer hs816 Neighboring gene uncharacterized LOC105375164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:14779612-14780128 Neighboring gene general transcription factor IIIA pseudogene 5 Neighboring gene uncharacterized LOC124901592 Neighboring gene alkylglycerol monooxygenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Both the C1 domain and a basic amino acid cluster at the C-terminus are important for the neurite and branch induction ability of DGKβ. Kano T, et al. Biochem Biophys Res Commun, 2014 Apr 25. PMID 24695318
  2. Diacylglycerol kinases: at the hub of cell signalling. Mérida I, et al. Biochem J, 2008 Jan 1. PMID 18062770
  3. DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma. Kang H, et al. Cell Rep Med, 2023 Jan 17. PMID 36603576, Free PMC Article
  4. GCK, GCKR, FADS1, DGKB/TMEM195 and CDKAL1 Gene Polymorphisms in Women with Gestational Diabetes. Tarnowski M, et al. Can J Diabetes, 2017 Aug. PMID 28359772
  5. Single nucleotide polymorphisms of the DGKB and VCAM1 genes are associated with granulocyte colony stimulating factor-mediated peripheral blood stem cell mobilization. Mishima S, et al. Transfus Apher Sci, 2017 Apr. PMID 27839966

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma.
    Title: DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma.
  2. RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output.
    Title: Discovering human diabetes-risk gene function with genetics and physiological assays.
  3. Association with the efficiency of hematopoietic stem cells (HSC) mobilization to PB were found in the SNPs of the DGKB gene involved in cell transport and SDF-1-induced migration ability and of the VCAM1 gene which is essential for HSC homing, suggesting that SNPs involved in cell migration ability might be partly involved in HSC mobilization to peripheral blood.
    Title: Single nucleotide polymorphisms of the DGKB and VCAM1 genes are associated with granulocyte colony stimulating factor-mediated peripheral blood stem cell mobilization.
  4. in addition to kinase activity, plasma membrane localization via the C1 domain and basic amino acids at the C-terminus were indispensable for neurite induction by DGKbeta
    Title: Both the C1 domain and a basic amino acid cluster at the C-terminus are important for the neurite and branch induction ability of DGKβ.
  5. forced expression of diacylglycerol kinase beta abrogated DAG accumulation at the phagosome, leading to impaired respiratory burst.
    Title: Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation.
  6. findings further suggest that DGL-alpha and -beta may regulate neurite outgrowth by engaging temporally and spatially distinct molecular pathways
    Title: Diacylglycerol lipase-alpha and -beta control neurite outgrowth in neuro-2a cells through distinct molecular mechanisms.
  7. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
    Title: Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
  8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  9. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.
  10. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
    Title: Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
EBI GWAS Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
EBI GWAS Catalog
Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.
EBI GWAS Catalog
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
EBI GWAS Catalog
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
EBI GWAS Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0718

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent diacylglycerol kinase activity TAS
Traceable Author Statement
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in diacylglycerol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycerolipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in platelet activation TAS
Traceable Author Statement
more info
  
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
diacylglycerol kinase beta
Names
90 kDa diacylglycerol kinase
DAG kinase beta
diacylglycerol kinase, beta 90kDa
diglyceride kinase beta
NP_001337634.1
NP_001337635.1
NP_001337636.1
NP_001337637.1
NP_001337638.1
NP_001337640.1
NP_001337641.1
NP_001337643.1
NP_001337644.1
NP_001337645.1
NP_001337646.1
NP_001337647.1
NP_001337648.1
NP_001337649.1
NP_001337650.1
NP_001337651.1
NP_001337652.1
NP_001337653.1
NP_663733.1
XP_011513456.1
XP_016867279.1
XP_016867280.1
XP_016867281.1
XP_047275885.1
XP_047275886.1
XP_054213340.1
XP_054213341.1
XP_054213342.1
XP_054213343.1
XP_054213344.1
XP_054213345.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029494.2 RefSeqGene

    Range
    77027..834729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001350705.1 → NP_001337634.1  diacylglycerol kinase beta isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Consensus CDS
    CCDS47547.1
    UniProtKB/Swiss-Prot
    A4D116, A4D117, A8MXU2, O75241, Q2M377, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29, Q9Y6T7
    UniProtKB/TrEMBL
    B7Z9A9
    Related
    ENSP00000385780.2, ENST00000403951.6
    Conserved Domains (6) summary
    smart00045
    Location:582 → 762
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:440 → 561
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245 → 294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153 → 222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310 → 359
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 149
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  2. NM_001350706.2 → NP_001337635.1  diacylglycerol kinase beta isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Consensus CDS
    CCDS47547.1
    UniProtKB/Swiss-Prot
    A4D116, A4D117, A8MXU2, O75241, Q2M377, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29, Q9Y6T7
    UniProtKB/TrEMBL
    B7Z9A9
    Related
    ENSP00000382260.3, ENST00000399322.7
    Conserved Domains (6) summary
    smart00045
    Location:582 → 762
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:440 → 561
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245 → 294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153 → 222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310 → 359
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 149
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  3. NM_001350707.2 → NP_001337636.1  diacylglycerol kinase beta isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform 3.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Consensus CDS
    CCDS87481.1
    UniProtKB/TrEMBL
    B5MBY2, B7Z9A9
    Conserved Domains (6) summary
    smart00045
    Location:581 → 761
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:439 → 560
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245 → 294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153 → 222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310 → 359
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 149
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  4. NM_001350708.1 → NP_001337637.1  diacylglycerol kinase beta isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform 3.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Consensus CDS
    CCDS87481.1
    UniProtKB/TrEMBL
    B5MBY2, B7Z9A9
    Conserved Domains (6) summary
    smart00045
    Location:581 → 761
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:439 → 560
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245 → 294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153 → 222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310 → 359
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 149
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  5. NM_001350709.2 → NP_001337638.1  diacylglycerol kinase beta isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform 3.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Consensus CDS
    CCDS87481.1
    UniProtKB/TrEMBL
    B5MBY2, B7Z9A9
    Related
    ENSP00000384909.1, ENST00000402815.6
    Conserved Domains (6) summary
    smart00045
    Location:581 → 761
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:439 → 560
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245 → 294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153 → 222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310 → 359
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 149
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  6. NM_001350711.2 → NP_001337640.1  diacylglycerol kinase beta isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 8 and 9, encodes isoform 4.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Consensus CDS
    CCDS87480.1
    UniProtKB/TrEMBL
    B5MCD5, B5MDK1, B7Z9A9
    Conserved Domains (6) summary
    smart00045
    Location:574 → 754
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:432 → 553
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:238 → 287
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:146 → 215
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:303 → 352
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 142
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  7. NM_001350712.1 → NP_001337641.1  diacylglycerol kinase beta isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 7 and 9, encodes isoform 4.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Consensus CDS
    CCDS87480.1
    UniProtKB/TrEMBL
    B5MCD5, B5MDK1, B7Z9A9
    Conserved Domains (6) summary
    smart00045
    Location:574 → 754
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:432 → 553
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:238 → 287
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:146 → 215
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:303 → 352
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 142
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  8. NM_001350714.2 → NP_001337643.1  diacylglycerol kinase beta isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 7 and 8, encodes isoform 4.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    Consensus CDS
    CCDS87480.1
    UniProtKB/TrEMBL
    B5MCD5, B5MDK1, B7Z9A9
    Related
    ENSP00000385031.1, ENST00000407950.5
    Conserved Domains (6) summary
    smart00045
    Location:574 → 754
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:432 → 553
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:238 → 287
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:146 → 215
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:303 → 352
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 142
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  9. NM_001350715.1 → NP_001337644.1  diacylglycerol kinase beta isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variant 11, encodes isoform 5.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    UniProtKB/TrEMBL
    B7Z9A9
    Conserved Domains (6) summary
    smart00045
    Location:575 → 755
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:433 → 554
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:238 → 287
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:146 → 215
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:303 → 352
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 142
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  10. NM_001350716.2 → NP_001337645.1  diacylglycerol kinase beta isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 10, encodes isoform 5.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    UniProtKB/TrEMBL
    B7Z9A9
    Conserved Domains (6) summary
    smart00045
    Location:575 → 755
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:433 → 554
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:238 → 287
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:146 → 215
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:303 → 352
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 142
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  11. NM_001350717.2 → NP_001337646.1  diacylglycerol kinase beta isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform 6.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    UniProtKB/TrEMBL
    B7Z9A9
    Conserved Domains (6) summary
    smart00045
    Location:570 → 750
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:428 → 549
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245 → 294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153 → 222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310 → 359
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 149
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  12. NM_001350718.1 → NP_001337647.1  diacylglycerol kinase beta isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform 6.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    UniProtKB/TrEMBL
    B7Z9A9
    Conserved Domains (6) summary
    smart00045
    Location:570 → 750
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:428 → 549
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245 → 294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153 → 222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310 → 359
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 149
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  13. NM_001350719.2 → NP_001337648.1  diacylglycerol kinase beta isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform 6.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    UniProtKB/TrEMBL
    B7Z9A9
    Conserved Domains (6) summary
    smart00045
    Location:570 → 750
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:428 → 549
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245 → 294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153 → 222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310 → 359
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 149
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  14. NM_001350720.1 → NP_001337649.1  diacylglycerol kinase beta isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform 7.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    UniProtKB/TrEMBL
    B7Z9A9
    Conserved Domains (6) summary
    smart00045
    Location:563 → 743
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:421 → 542
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:238 → 287
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:146 → 215
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:303 → 352
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 142
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  15. NM_001350721.2 → NP_001337650.1  diacylglycerol kinase beta isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform 7.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    UniProtKB/TrEMBL
    B7Z9A9
    Conserved Domains (6) summary
    smart00045
    Location:563 → 743
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:421 → 542
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:238 → 287
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:146 → 215
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:303 → 352
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 142
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  16. NM_001350722.2 → NP_001337651.1  diacylglycerol kinase beta isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 18, encodes isoform 8.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    UniProtKB/TrEMBL
    B7Z9A9
    Conserved Domains (6) summary
    smart00045
    Location:540 → 720
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:398 → 519
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:203 → 252
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:111 → 180
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:268 → 317
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:14 → 107
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  17. NM_001350723.2 → NP_001337652.1  diacylglycerol kinase beta isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 17, encodes isoform 8.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    UniProtKB/TrEMBL
    B7Z9A9
    Conserved Domains (6) summary
    smart00045
    Location:540 → 720
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:398 → 519
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:203 → 252
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:111 → 180
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:268 → 317
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:14 → 107
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  18. NM_001350724.2 → NP_001337653.1  diacylglycerol kinase beta isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) encodes isoform 9.
    Source sequence(s)
    AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
    UniProtKB/TrEMBL
    B7Z9A9
    Conserved Domains (6) summary
    smart00045
    Location:532 → 712
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:390 → 511
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:196 → 245
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:104 → 173
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:261 → 310
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7 → 100
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  19. NM_145695.2 → NP_663733.1  diacylglycerol kinase beta isoform 2

    See identical proteins and their annotated locations for NP_663733.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a distinct 3' UTR and 3' coding region compared to variant (1). The encoded protein (2) has a shorter, alternate C-terminus compared to isoform (1).
    Source sequence(s)
    AC005039, BC105005, DA321150
    Consensus CDS
    CCDS47548.1
    UniProtKB/TrEMBL
    B7ZL83
    Related
    ENSP00000386066.3, ENST00000406247.7
    Conserved Domains (6) summary
    smart00045
    Location:582 → 762
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:440 → 561
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245 → 294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153 → 222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310 → 359
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 149
    DAG_kinase_N; Diacylglycerol kinase N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    14145049..14974858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515154.3 → XP_011513456.1  diacylglycerol kinase beta isoform X1

    See identical proteins and their annotated locations for XP_011513456.1

    UniProtKB/Swiss-Prot
    A4D116, A4D117, A8MXU2, O75241, Q2M377, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29, Q9Y6T7
    UniProtKB/TrEMBL
    B7Z9A9
    Conserved Domains (6) summary
    smart00045
    Location:582 → 762
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:440 → 561
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245 → 294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153 → 222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310 → 359
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 149
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  2. XM_047419929.1 → XP_047275885.1  diacylglycerol kinase beta isoform X3

  3. XM_017011790.2 → XP_016867279.1  diacylglycerol kinase beta isoform X2

    UniProtKB/TrEMBL
    B7ZL83
    Conserved Domains (7) summary
    smart00046
    Location:440 → 561
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:245 → 294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:153 → 222
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:310 → 361
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:154 → 218
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:6 → 149
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cl02440
    Location:582 → 679
    DAGK_acc; Diacylglycerol kinase accessory domain

  4. XM_017011791.2 → XP_016867280.1  diacylglycerol kinase beta isoform X4

  5. XM_047419930.1 → XP_047275886.1  diacylglycerol kinase beta isoform X6

  6. XM_017011792.3 → XP_016867281.1  diacylglycerol kinase beta isoform X5

RNA

  1. XR_001744571.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    14277079..15107587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357365.1 → XP_054213340.1  diacylglycerol kinase beta isoform X1

    UniProtKB/Swiss-Prot
    A4D116, A4D117, A8MXU2, O75241, Q2M377, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29, Q9Y6T7

  2. XM_054357367.1 → XP_054213342.1  diacylglycerol kinase beta isoform X3

  3. XM_054357366.1 → XP_054213341.1  diacylglycerol kinase beta isoform X2

  4. XM_054357368.1 → XP_054213343.1  diacylglycerol kinase beta isoform X4

  5. XM_054357370.1 → XP_054213345.1  diacylglycerol kinase beta isoform X6

  6. XM_054357369.1 → XP_054213344.1  diacylglycerol kinase beta isoform X5

RNA

  1. XR_008487537.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004080.2: Suppressed sequence

    Description
    NM_004080.2: This RefSeq was removed because currently there is insufficient support for the 5' end of the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6T7.2 GenPept UniProtKB/Swiss-Prot:Q9Y6T7

Gene LinkOut

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