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ZDHHC15 zinc finger DHHC-type palmitoyltransferase 15 [ Homo sapiens (human) ]

Gene ID: 158866, updated on 3-Apr-2024

Summary

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Official Symbol
ZDHHC15provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 15provided by HGNC
Primary source
HGNC:HGNC:20342
See related
Ensembl:ENSG00000102383 MIM:300576; AllianceGenome:HGNC:20342
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRX91; DHHC15
Summary
The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Expression
Broad expression in brain (RPKM 1.4), thyroid (RPKM 0.9) and 21 other tissues See more
Orthologs
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Genomic context

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Location:
Xq13.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (75368427..75523037, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (73802127..73956714, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (74588262..74742872, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905200 Neighboring gene uracil phosphoribosyltransferase homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29773 Neighboring gene TERF1 pseudogene 7 Neighboring gene ribosomal protein L21 pseudogene 134 Neighboring gene uncharacterized LOC107985664 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:74780229-74780730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:74780731-74781230 Neighboring gene PEST containing nuclear protein pseudogene 4 Neighboring gene BRAF pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma. Liu ZY, et al. BMC Cancer, 2023 May 9. PMID 37161425, Free PMC Article
  2. ZDHHC15 as a candidate gene for autism spectrum disorder. Casellas-Vidal D, et al. Am J Med Genet A, 2023 Apr. PMID 36565021
  3. Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation. Fan X, et al. Stem Cell Res Ther, 2021 Feb 4. PMID 33541421, Free PMC Article
  4. Loss of ZDHHC15 expression in a woman with a balanced translocation t(X;15)(q13.3;cen) and severe mental retardation. Mansouri MR, et al. Eur J Hum Genet, 2005 Aug. PMID 15915161
  5. Palmitoylation controls recycling in lysosomal sorting and trafficking. McCormick PJ, et al. Traffic, 2008 Nov. PMID 18817523, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma.
    Title: ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma.
  2. ZDHHC15 as a candidate gene for autism spectrum disorder.
    Title: ZDHHC15 as a candidate gene for autism spectrum disorder.
  3. Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.
    Title: Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2012-07-25)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2012-07-25)

ClinGen Genome Curation Page

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31812, MGC119974, MGC119975, MGC119976

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-cysteine S-myristoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-cysteine S-stearoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to postsynapse ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein targeting to Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptic vesicle maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynapse ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC15
Names
DHHC-15
acyltransferase ZDHHC15
zinc finger DHHC domain-containing protein 15
zinc finger DHHC-type containing 15
zinc finger, DHHC domain containing 15
NP_001139728.1
NP_001139729.1
NP_659406.1
XP_006724687.1
XP_016884785.1
XP_024308110.1
XP_047297821.1
XP_047297822.1
XP_047297823.1
XP_047297824.1
XP_047297825.1
XP_054182523.1
XP_054182524.1
XP_054182525.1
XP_054182526.1
XP_054182527.1
XP_054182528.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012974.1 RefSeqGene

    Range
    5466..160076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001146256.2 → NP_001139728.1  palmitoyltransferase ZDHHC15 isoform 2

    See identical proteins and their annotated locations for NP_001139728.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is lacking an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) missing a 9 aa segment compared to isoform 1.
    Source sequence(s)
    AK056374, AK122885, AK123754, AK128587, AL137013, BQ028106
    Consensus CDS
    CCDS55454.1
    UniProtKB/TrEMBL
    B3KY34
    Related
    ENSP00000445420.1, ENST00000541184.1
    Conserved Domains (1) summary
    cl19890
    Location:117 → 299
    zf-DHHC; DHHC palmitoyltransferase

  2. NM_001146257.2 → NP_001139729.1  palmitoyltransferase ZDHHC15 isoform 3

    See identical proteins and their annotated locations for NP_001139729.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is lacking an in-frame coding exon and differs at the 3' end compared to variant 1. This results in a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC020717, AY358786
    UniProtKB/Swiss-Prot
    Q96MV8

  3. NM_144969.3 → NP_659406.1  palmitoyltransferase ZDHHC15 isoform 1

    See identical proteins and their annotated locations for NP_659406.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK056374, AK122885, AK123754, AK128587, AL137013, BQ028106
    Consensus CDS
    CCDS14430.1
    UniProtKB/Swiss-Prot
    B3KVG7, Q3SY30, Q6UWH3, Q96MV8
    UniProtKB/TrEMBL
    B3KY34
    Related
    ENSP00000362465.3, ENST00000373367.8
    Conserved Domains (1) summary
    cl19890
    Location:126 → 308
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    75368427..75523037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452342.1 → XP_024308110.1  palmitoyltransferase ZDHHC15 isoform X5

    Conserved Domains (1) summary
    cl19890
    Location:18 → 200
    zf-DHHC; DHHC palmitoyltransferase

  2. XM_047441867.1 → XP_047297823.1  palmitoyltransferase ZDHHC15 isoform X3

  3. XM_047441866.1 → XP_047297822.1  palmitoyltransferase ZDHHC15 isoform X3

  4. XM_006724624.5 → XP_006724687.1  palmitoyltransferase ZDHHC15 isoform X1

    See identical proteins and their annotated locations for XP_006724687.1

    UniProtKB/Swiss-Prot
    B3KVG7, Q3SY30, Q6UWH3, Q96MV8
    UniProtKB/TrEMBL
    B3KY34
    Conserved Domains (1) summary
    cl19890
    Location:126 → 308
    zf-DHHC; DHHC palmitoyltransferase

  5. XM_047441865.1 → XP_047297821.1  palmitoyltransferase ZDHHC15 isoform X1

    UniProtKB/Swiss-Prot
    B3KVG7, Q3SY30, Q6UWH3, Q96MV8

  6. XM_047441869.1 → XP_047297825.1  palmitoyltransferase ZDHHC15 isoform X6

  7. XM_047441868.1 → XP_047297824.1  palmitoyltransferase ZDHHC15 isoform X4

  8. XM_017029296.3 → XP_016884785.1  palmitoyltransferase ZDHHC15 isoform X2

    UniProtKB/TrEMBL
    B3KY34

RNA

  1. XR_001755658.3 RNA Sequence

  2. XR_938393.3 RNA Sequence

  3. XR_007068181.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    73802127..73956714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326552.1 → XP_054182527.1  palmitoyltransferase ZDHHC15 isoform X5

  2. XM_054326549.1 → XP_054182524.1  palmitoyltransferase ZDHHC15 isoform X3

  3. XM_054326548.1 → XP_054182523.1  palmitoyltransferase ZDHHC15 isoform X1

    UniProtKB/Swiss-Prot
    B3KVG7, Q3SY30, Q6UWH3, Q96MV8

  4. XM_054326553.1 → XP_054182528.1  palmitoyltransferase ZDHHC15 isoform X6

  5. XM_054326551.1 → XP_054182526.1  palmitoyltransferase ZDHHC15 isoform X4

  6. XM_054326550.1 → XP_054182525.1  palmitoyltransferase ZDHHC15 isoform X2

RNA

  1. XR_008485456.1 RNA Sequence

  2. XR_008485455.1 RNA Sequence

  3. XR_008485457.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96MV8.1 GenPept UniProtKB/Swiss-Prot:Q96MV8

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