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CXorf65 chromosome X open reading frame 65 [ Homo sapiens (human) ]

Gene ID: 158830, updated on 5-Mar-2024

Summary

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Official Symbol
CXorf65provided by HGNC
Official Full Name
chromosome X open reading frame 65provided by HGNC
Primary source
HGNC:HGNC:33713
See related
Ensembl:ENSG00000204165 AllianceGenome:HGNC:33713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 7.7), lymph node (RPKM 2.7) and 5 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
Xq13.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (71103889..71106740, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (69537985..69540832, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (70323739..70326590, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene sorting nexin 12 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:70288147-70288340 Neighboring gene Sharpr-MPRA regulatory region 4327 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:70320272-70320882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29736 Neighboring gene forkhead box O4 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:70330888-70332087 Neighboring gene interleukin 2 receptor subunit gamma Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:70342400-70343599 Neighboring gene mediator complex subunit 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Gm614 Protects Germinal Center B Cells From Death by Suppressing Caspase-1 Transcription in Lupus-Prone Mice. He Y, et al. Front Immunol, 2020. PMID 33193409, Free PMC Article
  2. Generation and analysis of 280,000 human expressed sequence tags. Hillier LD, et al. Genome Res, 1996 Sep. PMID 8889549
  3. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

General protein information

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Preferred Names
uncharacterized protein CXorf65

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021141.1 RefSeqGene

    Range
    5049..7900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025265.3 → NP_001020436.1  uncharacterized protein CXorf65

    See identical proteins and their annotated locations for NP_001020436.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AL590764, DB457782, DB523273
    Consensus CDS
    CCDS35324.1
    UniProtKB/Swiss-Prot
    A6NEN9
    Related
    ENSP00000363369.4, ENST00000374251.6
    Conserved Domains (1) summary
    pfam15874
    Location:2 → 102
    Il2rg; Putative Interleukin 2 receptor, gamma chain

RNA

  1. NR_033212.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in a 5' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL590764, BC144434
    Related
    ENST00000438526.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    71103889..71106740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262244.5 → XP_005262301.1  uncharacterized protein CXorf65 isoform X1

    Conserved Domains (1) summary
    pfam15874
    Location:2 → 83
    Il2rg; Putative Interleukin 2 receptor, gamma chain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    69537985..69540832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326546.1 → XP_054182521.1  uncharacterized protein CXorf65 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NEN9.1 GenPept UniProtKB/Swiss-Prot:A6NEN9

Gene LinkOut

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