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FAM120AOS family with sequence similarity 120 member A opposite strand [ Homo sapiens (human) ]

Gene ID: 158293, updated on 5-Mar-2024

Summary

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Official Symbol
FAM120AOSprovided by HGNC
Official Full Name
family with sequence similarity 120 member A opposite strandprovided by HGNC
Primary source
HGNC:HGNC:23389
See related
Ensembl:ENSG00000188938 AllianceGenome:HGNC:23389
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf10OS
Summary
Differences in the expression level of this gene are associated with the survival rate of those with glioma. [provided by RefSeq, May 2017]
Expression
Ubiquitous expression in thyroid (RPKM 13.5), colon (RPKM 12.6) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
9q22.31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (93443332..93453601, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (105610738..105621013, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (96205614..96215883, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 829, pseudogene Neighboring gene uncharacterized LOC107987097 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:96213447-96213996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20045 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28621 Neighboring gene Sharpr-MPRA regulatory region 4009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96222857-96223356 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:96228924-96229490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28623 Neighboring gene family with sequence similarity 120 member A Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:96244807-96245307 Neighboring gene MIA SH3 domain ER export factor 2 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr9:96271147-96271342 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:96273606-96273793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96337173-96337768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96337769-96338363 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96350491-96350991 Neighboring gene Sharpr-MPRA regulatory region 10393 Neighboring gene PHD finger protein 2 Neighboring gene microRNA 548au

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Independent validation of a mathematical genomic model for survival of glioma patients. Nikas JB. Am J Cancer Res, 2016. PMID 27429853, Free PMC Article
  2. A genome-wide association study of body mass index across early life and childhood. Warrington NM, et al. Int J Epidemiol, 2015 Apr. PMID 25953783, Free PMC Article
  3. A mathematical model for short-term vs. long-term survival in patients with glioma. Nikas JB. Am J Cancer Res, 2014. PMID 25520874, Free PMC Article
  4. The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34. Holden S, et al. Gene, 2003 Oct 30. PMID 14585507
  5. Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families. Alazami AM, et al. Cell Rep, 2015 Jan 13. PMID 25558065

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31534

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein FAM120AOS
Names
FAM120A opposite strand protein
family with sequence similarity 120A opposite strand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054727.2 RefSeqGene

    Range
    5020..15269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322224.3 → NP_001309153.1  uncharacterized protein FAM120AOS isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL353629, AL583839, AW016692
    Consensus CDS
    CCDS83385.1
    UniProtKB/TrEMBL
    E9PCY8, Q5T040
    Related
    ENSP00000414298.1, ENST00000423591.5

  2. NM_198841.4 → NP_942138.2  uncharacterized protein FAM120AOS isoform 1

    See identical proteins and their annotated locations for NP_942138.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK056096, AL353629, AL583839, AW016692, BC038803
    Consensus CDS
    CCDS6705.1
    UniProtKB/Swiss-Prot
    A6NN20, Q5T036
    UniProtKB/TrEMBL
    B3KPB1
    Related
    ENSP00000364561.5, ENST00000375412.11

RNA

  1. NR_136229.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the first exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL353629, AL583839, AW016692

  2. NR_136230.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the first exon and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL353629, AL583839, AW016692

  3. NR_136231.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL353629, AL583839, AW016692

  4. NR_136232.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an alternate first exon and an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL353629, AL583839, AW016692

  5. NR_136233.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an alternate first exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL353629, AL583839, AW016692

  6. NR_136234.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains an alternate first exon and an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL353629, AL583839, AW016692

  7. NR_136235.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) contains an alternate first exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL353629, AL583839, AW016692

  8. NR_136236.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) contains an alternate first exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL353629, AL583839, AW016692

  9. NR_136237.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) contains an alternate first exon and an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL353629, AL583839, AW016692

  10. NR_136238.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) contains an alternate first exon and an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL353629, AL583839, AW016692

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    93443332..93453601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    105610738..105621013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T036.1 GenPept UniProtKB/Swiss-Prot:Q5T036

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