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TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough [ Homo sapiens (human) ]

Gene ID: 157542, updated on 5-Mar-2024

Summary

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Official Symbol
TMEM276-ZFTRAF1provided by HGNC
Official Full Name
TMEM276-ZFTRAF1 readthroughprovided by HGNC
Primary source
HGNC:HGNC:56752
See related
Ensembl:ENSG00000291316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LOC84773-CYHR1
Summary
This locus represents naturally occurring read-through transcription between the neighboring LOC84773 and cysteine and histidine rich 1 (CYHR1). It encodes a fusion protein that shares sequence identity with proteins encoded by both independent genes. [provided by RefSeq, Feb 2022]
Orthologs
all
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Genomic context

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Location:
8q24.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144449582..144465701, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145619341..145635457, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145675314..145690875, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145651263-145652026 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19684 Neighboring gene VPS28 subunit of ESCRT-I Neighboring gene tonsoku like, DNA repair protein Neighboring gene TONSL antisense RNA 1 Neighboring gene microRNA 6893 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145668715-145669223 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19685 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19686 Neighboring gene zinc finger TRAF-type containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145687825-145688502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145688503-145689180 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145689275-145689888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145692087-145692923 Neighboring gene microRNA 10400 Neighboring gene transmembrane protein 276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19695 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145698787-145699682 Neighboring gene kinesin family member C2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145699683-145700576 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145701473-145702366 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19696 Neighboring gene forkhead box H1 Neighboring gene protein phosphatase 1 regulatory subunit 16A Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145709653-145710352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145710353-145711052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145715271-145715770 Neighboring gene uncharacterized LOC101928953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145725199-145725860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19697

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Homology

General protein information

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Preferred Names
uncharacterized protein LOC157542
Names
LOC84773-CYHR1 readthrough
TMEM276-CYHR1 readthrough

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408008.1 → NP_001394937.1  uncharacterized protein LOC157542 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  2. NM_001408009.1 → NP_001394938.1  uncharacterized protein LOC157542 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  3. NM_001408010.1 → NP_001394939.1  uncharacterized protein LOC157542 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  4. NM_001408011.1 → NP_001394940.1  uncharacterized protein LOC157542 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  5. NM_001408017.1 → NP_001394946.1  uncharacterized protein LOC157542 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  6. NM_001408018.1 → NP_001394947.1  uncharacterized protein LOC157542 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  7. NM_001408019.1 → NP_001394948.1  uncharacterized protein LOC157542 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  8. NM_001408020.1 → NP_001394949.1  uncharacterized protein LOC157542 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  9. NM_001408021.1 → NP_001394950.1  uncharacterized protein LOC157542 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  10. NM_001408022.1 → NP_001394951.1  uncharacterized protein LOC157542 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  11. NM_001408023.1 → NP_001394952.1  uncharacterized protein LOC157542 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  12. NM_001408024.1 → NP_001394953.1  uncharacterized protein LOC157542 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  13. NM_001408025.1 → NP_001394954.1  uncharacterized protein LOC157542 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  14. NM_001408026.1 → NP_001394955.1  uncharacterized protein LOC157542 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  15. NM_001408027.1 → NP_001394956.1  uncharacterized protein LOC157542 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  16. NM_001408028.1 → NP_001394957.1  uncharacterized protein LOC157542 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  17. NM_001408029.1 → NP_001394958.1  uncharacterized protein LOC157542 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084125

  18. NM_138496.3 → NP_612505.1  uncharacterized protein LOC157542 isoform 1 precursor

    See identical proteins and their annotated locations for NP_612505.1

    Status: VALIDATED

    Source sequence(s)
    AC084125
    UniProtKB/Swiss-Prot
    Q6ZMK1
    Related
    ENSP00000387426.2, ENST00000438911.6
    Conserved Domains (2) summary
    cl17238
    Location:83 → 114
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl19105
    Location:124 → 185
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    144449582..144465701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    145619341..145635457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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