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Ggt7 gamma-glutamyltransferase 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 156275, updated on 28-Oct-2024

Summary

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Official Symbol
Ggt7provided by RGD
Official Full Name
gamma-glutamyltransferase 7provided by RGD
Primary source
RGD:619870
See related
EnsemblRapid:ENSRNOG00000018441 AllianceGenome:RGD:619870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ggtl3
Summary
Predicted to enable glutathione hydrolase activity. Predicted to be involved in glutathione catabolic process and negative regulation of response to oxidative stress. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human GGT7 (gamma-glutamyltransferase 7). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Brain (RPKM 72.4), Thymus (RPKM 8.6) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ggt7 in Genome Data Viewer
Location:
3q42
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (164438240..164464059, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (143978073..144004597, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (151005960..151029941, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 6 Neighboring gene U1 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA18 Neighboring gene acyl-CoA synthetase short-chain family member 2 Neighboring gene glutathione synthetase Neighboring gene myosin heavy chain 7B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular characterization of a novel gamma-glutamyl transpeptidase homologue found in rat brain. Yamaguchi T, et al. J Biochem, 2000 Jul. PMID 10876163
  2. γ-Glutamyl transferase 7 is a novel regulator of glioblastoma growth. Bui TT, et al. BMC Cancer, 2015 Apr 7. PMID 25884624, Free PMC Article
  3. Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism. He X, et al. Biochem Biophys Res Commun, 2002 Sep 27. PMID 12270127
  4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene C4 gamma-glutamyl transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutathione hydrolase 7
Names
GGT 7
gamma-glutamyltransferase-like 3
gamma-glutamyltranspeptidase 7
NP_569107.2
XP_008760522.1
XP_038960082.1
XP_038960083.1
XP_038960084.1
XP_038960085.1
XP_038960086.1
XP_038960087.1
XP_038960088.1
XP_038960090.1
XP_063139093.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130423.2 → NP_569107.2  glutathione hydrolase 7

    See identical proteins and their annotated locations for NP_569107.2

    Status: VALIDATED

    Source sequence(s)
    AA925130, AF244973, CB761916
    UniProtKB/Swiss-Prot
    Q99MZ4
    UniProtKB/TrEMBL
    A6KI39, A6KI40
    Related
    ENSRNOP00000025315.4, ENSRNOT00000025315.7
    Conserved Domains (1) summary
    pfam01019
    Location:155 → 653
    G_glu_transpept; Gamma-glutamyltranspeptidase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    164438240..164464059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104160.2 → XP_038960088.1  glutathione hydrolase 7 isoform X9

    UniProtKB/TrEMBL
    A6KI39
    Conserved Domains (1) summary
    pfam01019
    Location:79 → 589
    G_glu_transpept; Gamma-glutamyltranspeptidase

  2. XM_039104156.2 → XP_038960084.1  glutathione hydrolase 7 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A1D7, A6KI39
    Related
    ENSRNOP00000085996.1, ENSRNOT00000103394.2
    Conserved Domains (1) summary
    pfam01019
    Location:155 → 660
    G_glu_transpept; Gamma-glutamyltranspeptidase

  3. XM_039104154.2 → XP_038960082.1  glutathione hydrolase 7 isoform X1

    UniProtKB/TrEMBL
    A6KI39
    Conserved Domains (1) summary
    pfam01019
    Location:155 → 665
    G_glu_transpept; Gamma-glutamyltranspeptidase

  4. XM_039104158.2 → XP_038960086.1  glutathione hydrolase 7 isoform X6

    UniProtKB/Swiss-Prot
    Q99MZ4
    UniProtKB/TrEMBL
    A6KI39, A6KI40
    Conserved Domains (1) summary
    pfam01019
    Location:155 → 653
    G_glu_transpept; Gamma-glutamyltranspeptidase

  5. XM_008762300.4 → XP_008760522.1  glutathione hydrolase 7 isoform X4

    UniProtKB/TrEMBL
    A6KI39
    Related
    ENSRNOP00000101168.1, ENSRNOT00000161417.1
    Conserved Domains (1) summary
    pfam01019
    Location:155 → 658
    G_glu_transpept; Gamma-glutamyltranspeptidase

  6. XM_039104157.2 → XP_038960085.1  glutathione hydrolase 7 isoform X5

    UniProtKB/TrEMBL
    A6KI39
    Conserved Domains (1) summary
    pfam01019
    Location:155 → 657
    G_glu_transpept; Gamma-glutamyltranspeptidase

  7. XM_039104155.2 → XP_038960083.1  glutathione hydrolase 7 isoform X2

    UniProtKB/TrEMBL
    A6KI39
    Conserved Domains (1) summary
    pfam01019
    Location:155 → 662
    G_glu_transpept; Gamma-glutamyltranspeptidase

  8. XM_063283023.1 → XP_063139093.1  glutathione hydrolase 7 isoform X8

    Related
    ENSRNOP00000084236.2, ENSRNOT00000110295.2

  9. XM_039104159.2 → XP_038960087.1  glutathione hydrolase 7 isoform X7

    UniProtKB/TrEMBL
    A6KI39
    Conserved Domains (1) summary
    pfam01019
    Location:100 → 610
    G_glu_transpept; Gamma-glutamyltranspeptidase

  10. XM_039104162.2 → XP_038960090.1  glutathione hydrolase 7 isoform X10

    Conserved Domains (1) summary
    cl19223
    Location:1 → 424
    G_glu_transpept; Gamma-glutamyltranspeptidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MZ4.2 GenPept UniProtKB/Swiss-Prot:Q99MZ4

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