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ZNF746 zinc finger protein 746 [ Homo sapiens (human) ]

Gene ID: 155061, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF746provided by HGNC
Official Full Name
zinc finger protein 746provided by HGNC
Primary source
HGNC:HGNC:21948
See related
Ensembl:ENSG00000181220 MIM:613914; AllianceGenome:HGNC:21948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PARIS
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and ubiquitin protein ligase binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of neuron death; and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 10.6), bone marrow (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF746 in Genome Data Viewer
Location:
7q36.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149472696..149497809, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150654556..150679673, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (149169787..149194900, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26814 Neighboring gene tRNA-Cys (anticodon GCA) 11-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149118879-149119378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18755 Neighboring gene zinc finger protein 777 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18758 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18759 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:149191224-149192423 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149193218-149194161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26816 Neighboring gene tRNA-Cys (anticodon GCA) 16-1 Neighboring gene tRNA-Cys (anticodon GCA) 22-1 Neighboring gene zinc finger family member 767, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genetic Analysis of ZNF Protein Family Members for Early-Onset Parkinson's Disease in Chinese Population. Li CY, et al. Mol Neurobiol, 2021 Jul. PMID 33723766
  2. PARIS-DJ-1 Interaction Regulates Mitochondrial Functions in Cardiomyocytes, Which Is Critically Important in Cardiac Hypertrophy. Mukherjee D, et al. Mol Cell Biol, 2020 Dec 21. PMID 33077496, Free PMC Article
  3. Inhibition of ZNF746 suppresses invasion and epithelial to mesenchymal transition in H460 non-small cell lung cancer cells. Kim B, et al. Oncol Rep, 2014 Jan. PMID 24145959
  4. SUMO-specific protease SENP3 enhances MDM2-mediated ubiquitination of PARIS/ZNF746 in HeLa cells. Nishida T. Biochem Biophys Res Commun, 2022 Jul 30. PMID 35623300
  5. ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma. Kim H, et al. Biochem Biophys Res Commun, 2021 Jul 23. PMID 34062393

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification.
    Title: PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification.
  2. ZNF746 promotes M2 macrophage polarisation and favours tumour progression in breast cancer via the Jagged1/Notch pathway.
    Title: ZNF746 promotes M2 macrophage polarisation and favours tumour progression in breast cancer via the Jagged1/Notch pathway.
  3. Genetic Analysis of ZNF Protein Family Members for Early-Onset Parkinson's Disease in Chinese Population.
    Title: Genetic Analysis of ZNF Protein Family Members for Early-Onset Parkinson's Disease in Chinese Population.
  4. ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma.
    Title: ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma.
  5. PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency.
    Title: PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency.
  6. PARIS-DJ-1 Interaction Regulates Mitochondrial Functions in Cardiomyocytes, Which Is Critically Important in Cardiac Hypertrophy.
    Title: PARIS-DJ-1 Interaction Regulates Mitochondrial Functions in Cardiomyocytes, Which Is Critically Important in Cardiac Hypertrophy.
  7. RNF4-mediated SUMO-targeted ubiquitination relieves PARIS/ZNF746-mediated transcriptional repression.
    Title: RNF4-mediated SUMO-targeted ubiquitination relieves PARIS/ZNF746-mediated transcriptional repression.
  8. We show that parkin is inactivated leading to the accumulation of parkin interacting substrate protein (PARIS) (zinc finger protein 746) (ZNF746) in 3 models of Parkinson's disease
    Title: Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease.
  9. the findings suggest that ZNF746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3beta and F-box/WD repeat-containing protein 7.
    Title: Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3β and F-box and WD repeat domain-containing 7.
  10. Taken together, these results suggest that PARIS and PIASy modulate PGC-1a gene transcription through distinct molecular mechanisms.
    Title: SUMOylation of the KRAB zinc-finger transcription factor PARIS/ZNF746 regulates its transcriptional activity.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31413

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein heterooligomerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein homooligomerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 746
Names
parkin-interacting substrate
parkin-interacting sustrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163474.2 → NP_001156946.1  zinc finger protein 746 isoform 1

    See identical proteins and their annotated locations for NP_001156946.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC004932, AI991498, AK291814, BC068505
    Consensus CDS
    CCDS55180.1
    UniProtKB/Swiss-Prot
    Q6NUN9
    Related
    ENSP00000508891.1, ENST00000685153.1
    Conserved Domains (6) summary
    cd07765
    Location:106 → 135
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:106 → 156
    KRAB; krueppel associated box
    COG5048
    Location:512 → 589
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:513 → 533
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:567 → 589
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:525 → 549
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001363517.2 → NP_001350446.1  zinc finger protein 746 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC004932, AC073314
    Consensus CDS
    CCDS87562.1
    UniProtKB/TrEMBL
    A0A2R8YDQ5
    Related
    ENSP00000493970.1, ENST00000644635.1
    Conserved Domains (4) summary
    smart00349
    Location:111 → 171
    KRAB; krueppel associated box
    COG5048
    Location:526 → 603
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:527 → 547
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:581 → 603
    zf-C2H2; Zinc finger, C2H2 type

  3. NM_001394198.1 → NP_001381127.1  zinc finger protein 746 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC004932, AC073314
    Consensus CDS
    CCDS94227.1
    UniProtKB/TrEMBL
    A0A8J9FQ52
    Related
    ENSP00000395007.3, ENST00000458143.7
    Conserved Domains (6) summary
    smart00349
    Location:111 → 171
    KRAB; krueppel associated box
    sd00017
    Location:528 → 548
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:582 → 604
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:569 → 593
    zf-H2C2_2; Zinc-finger double domain
    pfam16622
    Location:522 → 548
    zf-C2H2_11; zinc-finger C2H2-type

  4. NM_152557.5 → NP_689770.3  zinc finger protein 746 isoform 2

    See identical proteins and their annotated locations for NP_689770.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks one residue near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AC004932, AC073314, AI991498, BC068505, BM512385
    Consensus CDS
    CCDS5897.1
    UniProtKB/Swiss-Prot
    A8K6Z9, Q6NUN9, Q6ZRF9
    Related
    ENSP00000345140.3, ENST00000340622.8
    Conserved Domains (6) summary
    cd07765
    Location:106 → 135
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:106 → 156
    KRAB; krueppel associated box
    COG5048
    Location:511 → 588
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:512 → 532
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:566 → 588
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:524 → 548
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    149472696..149497809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419925.1 → XP_047275881.1  zinc finger protein 746 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    150654556..150679673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357354.1 → XP_054213329.1  zinc finger protein 746 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NUN9.1 GenPept UniProtKB/Swiss-Prot:Q6NUN9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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