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CLEC2L C-type lectin domain family 2 member L [ Homo sapiens (human) ]

Gene ID: 154790, updated on 5-Mar-2024

Summary

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Official Symbol
CLEC2Lprovided by HGNC
Official Full Name
C-type lectin domain family 2 member Lprovided by HGNC
Primary source
HGNC:HGNC:21969
See related
Ensembl:ENSG00000236279 AllianceGenome:HGNC:21969
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable carbohydrate binding activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 5.6), endometrium (RPKM 0.5) and 1 other tissue See more
Orthologs
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Genomic context

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See CLEC2L in Genome Data Viewer
Location:
7q34
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (139523685..139544985)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (140836984..140858283)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (139208431..139229731)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139136252-139137140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:139137141-139138027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:139138916-139139802 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:139146664-139147433 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:139150055-139150776 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:139152221-139152942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:139153665-139154386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139154387-139155106 Neighboring gene RNA, U6 small nuclear 911, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139164565-139165065 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139164064-139164564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18697 Neighboring gene killer cell lectin like receptor G2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139226381-139227154 Neighboring gene ST13, Hsp70 interacting protein pseudogene 17 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139229072-139229673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139253336-139253836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139253837-139254337 Neighboring gene uncharacterized LOC105375530 Neighboring gene ERH pseudogene 1 Neighboring gene homeodomain interacting protein kinase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26765 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:139311135-139311345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18698 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:139365244-139366443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26767 Neighboring gene NANOG hESC enhancer GRCh37_chr7:139377579-139378080 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:139411674-139412500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139415914-139416414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139416415-139416915 Neighboring gene Sharpr-MPRA regulatory region 6205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18700 Neighboring gene Sharpr-MPRA regulatory region 3006 Neighboring gene MPRA-validated peak6784 silencer Neighboring gene thromboxane A synthase 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:139528736-139529935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26770 Neighboring gene uncharacterized LOC107986853

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
  2. Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931, Free PMC Article
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32986

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C-type lectin domain family 2 member L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080511.4 → NP_001073980.2  C-type lectin domain family 2 member L isoform 1

    See identical proteins and their annotated locations for NP_001073980.2

    Status: VALIDATED

    Source sequence(s)
    AC005531, HY072821
    Consensus CDS
    CCDS47724.1
    UniProtKB/Swiss-Prot
    P0C7M8
    Related
    ENSP00000390661.2, ENST00000422142.7
    Conserved Domains (1) summary
    cd03593
    Location:100 → 210
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  2. NM_001353368.2 → NP_001340297.1  C-type lectin domain family 2 member L isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005531
    Conserved Domains (1) summary
    cd03593
    Location:75 → 185
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    139523685..139544985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011770.3 → XP_016867259.1  C-type lectin domain family 2 member L isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    140836984..140858283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357343.1 → XP_054213318.1  C-type lectin domain family 2 member L isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C7M8.1 GenPept UniProtKB/Swiss-Prot:P0C7M8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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