Hoxa10 homeobox A10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hoxa10provided by MGI
Official Full Name: homeobox A10provided by MGI
Primary source: MGI:MGI:96171
See related: Ensembl:ENSMUSG00000000938 AllianceGenome:MGI:96171
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hox-1.8; Hoxa-10
Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of a cluster on chromosome 6 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression: Biased expression in limb E14.5 (RPKM 27.5), subcutaneous fat pad adult (RPKM 20.5) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 25.4 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (52208177..52217658, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (52231197..52240854, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HOXA10 promotes Gdf5 expression in articular chondrocytes.
Title: HOXA10 promotes Gdf5 expression in articular chondrocytes.
LncRNA NEAT1 affects endometrial receptivity by regulating HOXA10 promoter activity.
Title: LncRNA NEAT1 affects endometrial receptivity by regulating HOXA10 promoter activity.
Loss of HOXA10 causes endometrial hyperplasia progressing to endometrial cancer.
Title: Loss of HOXA10 causes endometrial hyperplasia progressing to endometrial cancer.
Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle.
Title: Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle.
Bone-targeted lncRNA OGRU alleviates unloading-induced bone loss via miR-320-3p/Hoxa10 axis.
Title: Bone-targeted lncRNA OGRU alleviates unloading-induced bone loss via miR-320-3p/Hoxa10 axis.
IHC profiling of HOXA10 revealed inverse correlations between HOXA10 expression and Gleason pattern, Gleason score, and pathological stage (P < 0.01).
Title: HOXA10 expression profiling in prostate cancer.
CAPN7 impairs embryo implantation via downregulating HOXA10 expression.
Title: Calpain7 impairs embryo implantation by downregulating β3-integrin expression via degradation of HOXA10.
These results suggest that progesterone receptor overexpression in endometrial stromal cells, likely due to high progesterone levels, triggers cyclin D3 and Hoxa-10 overexpression, which may be involved in the pathological mechanisms of the mouse uterine decidual reaction.
Title: Hoxa-10 and Cyclin D3 Overexpression in the Decidual Reaction in a Superovulation Protocol in Young Adult C57BL/6J Mice.
Gene-environment interactions driven by early life xenoestrogen exposure likely contributes to increased risk of estrogen-related disease in adults.-
Title: Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol-A) exposure.
Hmgn5 might act downstream of Hoxa10 to regulate the expression of Cox-2, Vegf and Mmp2.
Title: Hmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mice.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hoxa10 (e-PCR), detects polymorphism
- UniSTS:143361

Hoxa10 (e-PCR), detects polymorphism
- UniSTS:143362

ECD01033 (e-PCR)
- UniSTS:282141

Hoxa10 (e-PCR), detects polymorphism
- UniSTS:536637

ECD00308 (e-PCR)
- UniSTS:281421

PMC140663P1 (e-PCR)
- UniSTS:270953

UniSTS:474751 (e-PCR)
- UniSTS:474751

Hoxa11 (e-PCR), detects polymorphism
- UniSTS:474751

RH135238 (e-PCR)
- UniSTS:218515

AA893141 (e-PCR)
- UniSTS:250019

U20370 (e-PCR)
- UniSTS:179373

ECD00416 (e-PCR)
- UniSTS:281527

L08757 (e-PCR)
- UniSTS:124870

REN100642 (e-PCR)
- UniSTS:425439

REN100644 (e-PCR)
- UniSTS:425441

REN100658 (e-PCR)
- UniSTS:425455

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic limb morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within male gonad development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within multicellular organism development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in prostate gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proximal/distal pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
involved_in response to testosterone	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within single fertilization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within uterus development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homeobox protein Hox-A10

Names: homeo box A10; homeobox protein Hox-1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.