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PPP1R2B PPP1R2 family member B [ Homo sapiens (human) ]

Gene ID: 153743, updated on 7-Apr-2024

Summary

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Official Symbol
PPP1R2Bprovided by HGNC
Official Full Name
PPP1R2 family member Bprovided by HGNC
Primary source
HGNC:HGNC:16318
See related
Ensembl:ENSG00000231989 AllianceGenome:HGNC:16318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP1R2P3
Summary
Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in regulation of phosphoprotein phosphatase activity. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See PPP1R2B in Genome Data Viewer
Location:
5q33.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (156850295..156852528)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (157369312..157371545)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (156277306..156279539)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene sarcoglycan delta Neighboring gene uncharacterized LOC105377673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23494 Neighboring gene NANOG hESC enhancer GRCh37_chr5:156225176-156225677 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:156229076-156229967 Neighboring gene RNA, U6 small nuclear 556, pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:156340819-156341764 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:156339619-156340818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23496 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:156441149-156441653 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:156441654-156442157 Neighboring gene apolipoprotein O pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:156477155-156477714 Neighboring gene T cell immunoglobulin and mucin domain containing 4 Neighboring gene hepatitis A virus cellular receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa. Korrodi-Gregório L, et al. BMC Cell Biol, 2013 Mar 18. PMID 23506001, Free PMC Article
  2. Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes. Korrodi-Gregório L, et al. BMC Evol Biol, 2013 Nov 6. PMID 24195737, Free PMC Article
  3. Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences. Sanséau P, et al. Mamm Genome, 1994 Aug. PMID 7949733
  4. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. Ceulemans H, et al. Bioessays, 2002 Apr. PMID 11948623
  5. Identification of the human testis protein phosphatase 1 interactome. Fardilha M, et al. Biochem Pharmacol, 2011 Nov 15. PMID 21382349

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PPP1R2P3 protein binds directly to PPP1CC and that this inhibitor cannot be phosphorylated by GSK3.
    Title: Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC87149

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase inhibitor 2 family member B
Names
protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 3
protein phosphatase 1, regulatory subunit 2 pseudogene 3
protein phosphatase inhibitor 2-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_206858.3 → NP_996740.2  protein phosphatase inhibitor 2 family member B

    Status: VALIDATED

    Source sequence(s)
    AC011414, BC066922
    Consensus CDS
    CCDS87340.1
    UniProtKB/Swiss-Prot
    G1AUC5, Q6NXS1
    UniProtKB/TrEMBL
    E7EMN6
    Related
    ENSP00000490297.1, ENST00000522232.3
    Conserved Domains (1) summary
    pfam04979
    Location:45 → 164
    IPP-2; Protein phosphatase inhibitor 2 (IPP-2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    156850295..156852528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    157369312..157371545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_038443.1: Suppressed sequence

    Description
    NR_038443.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NXS1.2 GenPept UniProtKB/Swiss-Prot:Q6NXS1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous