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BTNL9 butyrophilin like 9 [ Homo sapiens (human) ]

Gene ID: 153579, updated on 3-Apr-2024

Summary

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Official Symbol
BTNL9provided by HGNC
Official Full Name
butyrophilin like 9provided by HGNC
Primary source
HGNC:HGNC:24176
See related
Ensembl:ENSG00000165810 MIM:620648; AllianceGenome:HGNC:24176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTN3; BTN8; VDLS1900
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in fat (RPKM 71.4), lung (RPKM 16.7) and 4 other tissues See more
Orthologs
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Genomic context

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See BTNL9 in Genome Data Viewer
Location:
5q35.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (181040266..181061521)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (181596648..181622763)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180467266..180488521)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene butyrophilin like 3 Neighboring gene RNA, U6 small nuclear 1036, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr5:180463160-180463538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180463783-180464709 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:180472882-180473409 Neighboring gene microRNA 8089 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180480410-180480974 Neighboring gene ribosomal protein L13 pseudogene 10 Neighboring gene tRNA-Val (anticodon CAC) 1-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A stop-gain variant in BTNL9 is associated with atherogenic lipid profiles. Carlson JC, et al. HGG Adv, 2023 Jan 12. PMID 36340932, Free PMC Article
  2. Butyrophilin-Like 9 (BTNL9) Suppresses Invasion and Correlates with Favorable Prognosis of Uveal Melanoma. Jiang Z, et al. Med Sci Monit, 2019 Apr 30. PMID 31039142, Free PMC Article
  3. Integrative omics analysis identifies biomarkers of idiopathic pulmonary fibrosis. Zheng P, et al. Cell Mol Life Sci, 2022 Jan 11. PMID 35015148
  4. BTNL9 is frequently downregulated and inhibits proliferation and metastasis via the P53/CDC25C and P53/GADD45 pathways in breast cancer. Mo Q, et al. Biochem Biophys Res Commun, 2021 May 14. PMID 33756341
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA CALML3-AS1 modulated by m[6]A modification induces BTNL9 methylation to drive non-small-cell lung cancer progression.
    Title: LncRNA CALML3-AS1 modulated by m(6)A modification induces BTNL9 methylation to drive non-small-cell lung cancer progression.
  2. A stop-gain variant in BTNL9 is associated with atherogenic lipid profiles.
    Title: A stop-gain variant in BTNL9 is associated with atherogenic lipid profiles.
  3. Integrative omics analysis identifies biomarkers of idiopathic pulmonary fibrosis.
    Title: Integrative omics analysis identifies biomarkers of idiopathic pulmonary fibrosis.
  4. BTNL9 is frequently downregulated and inhibits proliferation and metastasis via the P53/CDC25C and P53/GADD45 pathways in breast cancer.
    Title: BTNL9 is frequently downregulated and inhibits proliferation and metastasis via the P53/CDC25C and P53/GADD45 pathways in breast cancer.
  5. Authors investigated the function of BTNL9 in UM proliferation and invasion. BTNL9 mRNAs in adjacent tissues were remarkably higher than in UM tissues. The percentages of BTNL9 low expression and high expression were 56.45% and 43.55%, respectively.
    Title: Butyrophilin-Like 9 (BTNL9) Suppresses Invasion and Correlates with Favorable Prognosis of Uveal Melanoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ99557

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
butyrophilin-like protein 9
Names
butyrophilin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308245.2 → NP_001295174.1  butyrophilin-like protein 9 isoform b precursor

    See identical proteins and their annotated locations for NP_001295174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 3' exon structure, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    BC062459, DC379841
    Consensus CDS
    CCDS78104.1
    UniProtKB/Swiss-Prot
    Q6UXG8
    Related
    ENSP00000366037.2, ENST00000376841.6
    Conserved Domains (1) summary
    cd05713
    Location:52 → 151
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)

  2. NM_152547.5 → NP_689760.2  butyrophilin-like protein 9 isoform a precursor

    See identical proteins and their annotated locations for NP_689760.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AY358358, BC042112, DC379841
    Consensus CDS
    CCDS4460.2
    UniProtKB/Swiss-Prot
    A6NL42, Q6P660, Q6UXG8, Q96DM5
    Related
    ENSP00000330200.9, ENST00000327705.14
    Conserved Domains (4) summary
    cd05713
    Location:52 → 151
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:46 → 150
    IG_like; Immunoglobulin like
    cd13733
    Location:329 → 503
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cl21462
    Location:281 → 317
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    181040266..181061521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454380.2 → XP_024310148.1  butyrophilin-like protein 9 isoform X1

    UniProtKB/TrEMBL
    A0A1S5UZ21
    Conserved Domains (3) summary
    cd13733
    Location:358 → 532
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cd05713
    Location:52 → 151
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    cl21462
    Location:281 → 317
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  2. XM_006714824.5 → XP_006714887.1  butyrophilin-like protein 9 isoform X4

    Conserved Domains (3) summary
    cd05713
    Location:52 → 151
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:46 → 150
    IG_like; Immunoglobulin like
    cd13733
    Location:322 → 496
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

  3. XM_047416816.1 → XP_047272772.1  butyrophilin-like protein 9 isoform X2

  4. XM_006714823.5 → XP_006714886.1  butyrophilin-like protein 9 isoform X3

    Conserved Domains (3) summary
    cd05713
    Location:52 → 151
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:46 → 150
    IG_like; Immunoglobulin like
    cd13733
    Location:322 → 496
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

  5. XM_017009113.3 → XP_016864602.1  butyrophilin-like protein 9 isoform X5

  6. XM_011534444.4 → XP_011532746.1  butyrophilin-like protein 9 isoform X7

    See identical proteins and their annotated locations for XP_011532746.1

    UniProtKB/Swiss-Prot
    Q6UXG8
    Conserved Domains (1) summary
    cd05713
    Location:52 → 151
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)

  7. XM_017009115.3 → XP_016864604.1  butyrophilin-like protein 9 isoform X8

    Related
    ENSP00000425424.1, ENST00000491209.5

  8. XM_047416817.1 → XP_047272773.1  butyrophilin-like protein 9 isoform X6

  9. XM_047416818.1 → XP_047272774.1  butyrophilin-like protein 9 isoform X6

  10. XM_047416819.1 → XP_047272775.1  butyrophilin-like protein 9 isoform X9

  11. XM_017009117.2 → XP_016864606.1  butyrophilin-like protein 9 isoform X10

    UniProtKB/TrEMBL
    Q8N324

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    181596648..181622763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351804.1 → XP_054207779.1  butyrophilin-like protein 9 isoform X1

  2. XM_054351805.1 → XP_054207780.1  butyrophilin-like protein 9 isoform X2

  3. XM_054351807.1 → XP_054207782.1  butyrophilin-like protein 9 isoform X4

  4. XM_054351806.1 → XP_054207781.1  butyrophilin-like protein 9 isoform X3

  5. XM_054351808.1 → XP_054207783.1  butyrophilin-like protein 9 isoform X5

  6. XM_054351811.1 → XP_054207786.1  butyrophilin-like protein 9 isoform X7

  7. XM_054351812.1 → XP_054207787.1  butyrophilin-like protein 9 isoform X8

  8. XM_054351809.1 → XP_054207784.1  butyrophilin-like protein 9 isoform X6

  9. XM_054351810.1 → XP_054207785.1  butyrophilin-like protein 9 isoform X6

  10. XM_054351813.1 → XP_054207788.1  butyrophilin-like protein 9 isoform X9

  11. XM_054351814.1 → XP_054207789.1  butyrophilin-like protein 9 isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UXG8.1 GenPept UniProtKB/Swiss-Prot:Q6UXG8

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