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TEX28 testis expressed 28 [ Homo sapiens (human) ]

Gene ID: 1527, updated on 14-Nov-2024

Summary

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Official Symbol
TEX28provided by HGNC
Official Full Name
testis expressed 28provided by HGNC
Primary source
HGNC:HGNC:2563
See related
Ensembl:ENSG00000278057 MIM:300092; AllianceGenome:HGNC:2563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
fTEX; MRX99; CXorf2; TEX28P1; TEX28P2
Summary
Predicted to be located in membrane. Predicted to be active in endomembrane system. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis (RPKM 2.4) See more
Orthologs
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Genomic context

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See TEX28 in Genome Data Viewer
Location:
Xq28
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (154271265..154295211, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152507099..152531726, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X (PATCHES) NW_003871103.3 (1705244..1729190, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TEX28 pseudogene 3 Neighboring gene opsin 1, medium wave sensitive 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153523339-153523840 Neighboring gene transketolase like 1 Neighboring gene uncharacterized LOC105373386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30055

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Evaluation of the X-linked high-grade myopia locus (MYP1) with cone dysfunction and color vision deficiencies. Metlapally R, et al. Invest Ophthalmol Vis Sci, 2009 Apr. PMID 19098318, Free PMC Article
  2. An insertion/deletion TEX28 polymorphism and its application to analysis of red/green visual pigment gene arrays. Ueyama H, et al. J Hum Genet, 2004. PMID 15378397
  3. Identification of a gene within the tandem array of red and green color pigment genes. Hanna MC, et al. Genomics, 1997 Aug 1. PMID 9268643
  4. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. Denoeud F, et al. Genome Res, 2007 Jun. PMID 17567994, Free PMC Article
  5. Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets. Mihalič F, et al. Nat Commun, 2023 Sep 13. PMID 37704626, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TEX28 gene CNVs (copy number variations) appear to be associated with the MYP1 X-linked myopia phenotypes.
    Title: Evaluation of the X-linked high-grade myopia locus (MYP1) with cone dysfunction and color vision deficiencies.
  2. proposed a structure of the second gene of 3-gene arrays, Green-pTEX-Green-pTEX-Green-fTEX and Red-pTEX-Red-pTEX-Red-fTEX, in color-vision-deficient subjects
    Title: An insertion/deletion TEX28 polymorphism and its application to analysis of red/green visual pigment gene arrays.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
testis-specific protein TEX28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205201.2 → NP_001192130.1  testis-specific protein TEX28

    See identical proteins and their annotated locations for NP_001192130.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC245140
    Consensus CDS
    CCDS14744.2
    UniProtKB/Swiss-Prot
    B1B1E8, D3DWW5, O15482
    Related
    ENSP00000478834.1, ENST00000619903.4
    Conserved Domains (1) summary
    pfam10267
    Location:48 → 380
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  2. NM_001586.3 → NP_001577.1  testis-specific protein TEX28

    See identical proteins and their annotated locations for NP_001577.1

    Status: VALIDATED

    Source sequence(s)
    AC245140
    Consensus CDS
    CCDS14744.2
    UniProtKB/Swiss-Prot
    B1B1E8, D3DWW5, O15482
    Related
    ENSP00000482010.1, ENST00000617225.5
    Conserved Domains (1) summary
    pfam10267
    Location:48 → 380
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    154271265..154295211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531118.3 → XP_011529420.1  testis-specific protein TEX28 isoform X2

    See identical proteins and their annotated locations for XP_011529420.1

    Conserved Domains (1) summary
    pfam10267
    Location:51 → 383
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  2. XM_011531117.1 → XP_011529419.1  testis-specific protein TEX28 isoform X2

    See identical proteins and their annotated locations for XP_011529419.1

    Conserved Domains (1) summary
    pfam10267
    Location:51 → 383
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  3. XM_011531116.1 → XP_011529418.1  testis-specific protein TEX28 isoform X1

    Conserved Domains (1) summary
    pfam10267
    Location:110 → 442
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    152507099..152531726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15482.1 GenPept UniProtKB/Swiss-Prot:O15482

Gene LinkOut

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