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PAQR3 progestin and adipoQ receptor family member 3 [ Homo sapiens (human) ]

Gene ID: 152559, updated on 3-Apr-2024

Summary

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Official Symbol
PAQR3provided by HGNC
Official Full Name
progestin and adipoQ receptor family member 3provided by HGNC
Primary source
HGNC:HGNC:30130
See related
Ensembl:ENSG00000163291 MIM:614577; AllianceGenome:HGNC:30130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RKTG
Summary
This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Expression
Broad expression in testis (RPKM 20.7), brain (RPKM 8.5) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
4q21.21
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (78887076..78939438, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (82222838..82275056, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (79833032..79860592, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:79696740-79697370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:79698003-79698633 Neighboring gene uncharacterized LOC124900722 Neighboring gene uncharacterized LOC105377299 Neighboring gene BMP2K divergent transcript Neighboring gene BMP2 inducible kinase Neighboring gene Sharpr-MPRA regulatory region 10702 Neighboring gene RNA, 7SL, cytoplasmic 127, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15515 Neighboring gene long intergenic non-protein coding RNA 1088 Neighboring gene uncharacterized LOC124900723 Neighboring gene MPRA-validated peak5059 silencer Neighboring gene N-alpha-acetyltransferase 11, NatA catalytic subunit Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:80169419-80169920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:80218690-80219258

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Golgi scaffold protein PAQR3 as a candidate suppressor of gastric cardia adenocarcinoma via regulating TGF-β/Smad pathway. Wu YL, et al. J Clin Lab Anal, 2022 Sep. PMID 35870178, Free PMC Article
  2. Silencing of PAQR3 suppresses extracellular matrix accumulation in high glucose-stimulated human glomerular mesangial cells via PI3K/AKT signaling pathway. Li H, et al. Eur J Pharmacol, 2018 Aug 5. PMID 29787774
  3. Aberrant promoter methylation of the PAQR3 gene is associated with prostate cancer. Lounglaithong K, et al. Pathol Res Pract, 2018 Jan. PMID 29122400
  4. PAQR3 overexpression suppresses the aggressive phenotype of esophageal squamous cell carcinoma cells via inhibition of ERK signaling. Bai G, et al. Biomed Pharmacother, 2017 Oct. PMID 28802234
  5. PAQR3 Inhibits the Proliferation and Tumorigenesis in Esophageal Cancer Cells. Zhou F, et al. Oncol Res, 2017 May 24. PMID 28548040, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Systematic pan-cancer analyses of the potential function of the Golgi scaffold protein PAQR3.
    Title: Systematic pan-cancer analyses of the potential function of the Golgi scaffold protein PAQR3.
  2. Golgi scaffold protein PAQR3 as a candidate suppressor of gastric cardia adenocarcinoma via regulating TGF-beta/Smad pathway.
    Title: Golgi scaffold protein PAQR3 as a candidate suppressor of gastric cardia adenocarcinoma via regulating TGF-β/Smad pathway.
  3. Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis.
    Title: Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis.
  4. PAQR3 inhibits proliferation and aggravates ferroptosis in acute lymphoblastic leukemia through modulation Nrf2 stability.
    Title: PAQR3 inhibits proliferation and aggravates ferroptosis in acute lymphoblastic leukemia through modulation Nrf2 stability.
  5. PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy.
    Title: PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy.
  6. Associations of the BRAF V600E Mutation and PAQR3 Protein Expression with Papillary Thyroid Carcinoma Clinicopathological Features.
    Title: Associations of the BRAF V600E Mutation and PAQR3 Protein Expression with Papillary Thyroid Carcinoma Clinicopathological Features.
  7. MiR-15b facilitates breast cancer progression via repressing tumor suppressor PAQR3.
    Title: MiR-15b facilitates breast cancer progression via repressing tumor suppressor PAQR3.
  8. PAQR3 might regulate the phosphorylation of FoxO1 and the expressions of GCK and LDLR through NF-kappaB pathway, thereby regulating the glucose and lipid metabolism disorders induced by insulin resistance.
    Title: PAQR3 regulates phosphorylation of FoxO1 in insulin-resistant HepG2 cells via NF-κB signaling pathway.
  9. Ubiquitination modification through the coordinated action of PAQR3 with HUWE1 plays a crucial role in regulating the activity of hepatic PPARalpha in response to starvation.
    Title: Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1.
  10. Silencing of PAQR3 suppresses extracellular matrix accumulation in high glucose-stimulated human glomerular mesangial cells via PI3K/AKT signaling pathway
    Title: Silencing of PAQR3 suppresses extracellular matrix accumulation in high glucose-stimulated human glomerular mesangial cells via PI3K/AKT signaling pathway.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein localization to Golgi apparatus IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
progestin and adipoQ receptor family member 3
Names
Raf kinase trapping to Golgi
progestin and adipoQ receptor family member III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053104.1 RefSeqGene

    Range
    5001..32561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040202.2 → NP_001035292.1  progestin and adipoQ receptor family member 3 isoform 1

    See identical proteins and their annotated locations for NP_001035292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC093841, AY424281, BX648346, DA410845
    Consensus CDS
    CCDS34020.1
    UniProtKB/Swiss-Prot
    A8K5B7, B3KP59, Q6PIQ1, Q6TCH7, Q86X05, Q8NCP9
    UniProtKB/TrEMBL
    F8W784
    Related
    ENSP00000421981.1, ENST00000512733.5
    Conserved Domains (1) summary
    pfam03006
    Location:64 → 283
    HlyIII; Haemolysin-III related

  2. NM_001350105.2 → NP_001337034.1  progestin and adipoQ receptor family member 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Both variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC093841
    Conserved Domains (1) summary
    cl03831
    Location:1 → 165
    HlyIII; Haemolysin-III related

  3. NM_001350106.2 → NP_001337035.1  progestin and adipoQ receptor family member 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Both variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC093841
    Conserved Domains (1) summary
    cl03831
    Location:1 → 165
    HlyIII; Haemolysin-III related

RNA

  1. NR_146462.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC093841

  2. NR_146463.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC093841

  3. NR_146464.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC093841

  4. NR_146465.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC093841

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    78887076..78939438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449645.1 → XP_047305601.1  progestin and adipoQ receptor family member 3 isoform X4

  2. XM_005262769.6 → XP_005262826.1  progestin and adipoQ receptor family member 3 isoform X2

    See identical proteins and their annotated locations for XP_005262826.1

    UniProtKB/TrEMBL
    F8W784
    Related
    ENSP00000344203.6, ENST00000342820.10
    Conserved Domains (1) summary
    cl03831
    Location:64 → 264
    HlyIII; Haemolysin-III related

  3. XM_024453910.2 → XP_024309678.1  progestin and adipoQ receptor family member 3 isoform X3

    Conserved Domains (1) summary
    cl03831
    Location:1 → 165
    HlyIII; Haemolysin-III related

  4. XM_047449643.1 → XP_047305599.1  progestin and adipoQ receptor family member 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K5B7, B3KP59, Q6PIQ1, Q6TCH7, Q86X05, Q8NCP9
    Related
    ENSP00000425080.1, ENST00000511594.5

RNA

  1. XR_938694.4 RNA Sequence

  2. XR_007096371.1 RNA Sequence

  3. XR_007096372.1 RNA Sequence

  4. XR_002959712.2 RNA Sequence

  5. XR_007096373.1 RNA Sequence

    Related
    ENST00000515853.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    82222838..82275056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348992.1 → XP_054204967.1  progestin and adipoQ receptor family member 3 isoform X4

  2. XM_054348991.1 → XP_054204966.1  progestin and adipoQ receptor family member 3 isoform X3

  3. XM_054348990.1 → XP_054204965.1  progestin and adipoQ receptor family member 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K5B7, B3KP59, Q6PIQ1, Q6TCH7, Q86X05, Q8NCP9

RNA

  1. XR_008486927.1 RNA Sequence

  2. XR_008486926.1 RNA Sequence

  3. XR_008486925.1 RNA Sequence

  4. XR_008486928.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177453.2: Suppressed sequence

    Description
    NM_177453.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TCH7.2 GenPept UniProtKB/Swiss-Prot:Q6TCH7

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