CXADR CXADR Ig-like cell adhesion molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CXADRprovided by HGNC
Official Full Name: CXADR Ig-like cell adhesion moleculeprovided by HGNC
Primary source: HGNC:HGNC:2559
See related: Ensembl:ENSG00000154639 MIM:602621; AllianceGenome:HGNC:2559
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAR; HCAR; CAR4/6
Summary: The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]
Expression: Ubiquitous expression in skin (RPKM 12.7), duodenum (RPKM 7.3) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 21q21.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	21	NC_000021.9 (17513043..17636262)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	21	NC_060945.1 (15868092..15991279)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	21	NC_000021.8 (18885361..18965928)

Chromosome 21 - NC_000021.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CXADR promote epithelial-mesenchymal transition in endometriosis by modulating AKT/GSK-3beta signaling.
Title: CXADR promote epithelial-mesenchymal transition in endometriosis by modulating AKT/GSK-3β signaling.
CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders.
Title: CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders.
Induction of the Coxsackievirus and Adenovirus Receptor in Macrophages During the Formation of Atherosclerotic Plaques.
Title: Induction of the Coxsackievirus and Adenovirus Receptor in Macrophages During the Formation of Atherosclerotic Plaques.
Naturally occurring variants in the transmembrane and cytoplasmic domains of the human Coxsackie- and adenovirus receptor have no impact on virus internalisation.
Title: Naturally occurring variants in the transmembrane and cytoplasmic domains of the human Coxsackie- and adenovirus receptor have no impact on virus internalisation.
CAR transcription levels were significantly lower (P=0.012) in patients with myocarditis compared with controls, and a significant decrease was observed (P=0.023) in CAR mRNA levels among patients with borderline myocarditis compared with the no myocarditis group.
Title: Differential expression of coxsackievirus and adenovirus receptor in endomyocardial tissue of patients with myocarditis.
Loss of CXADR expression is associated with Epithelial-Mesenchymal Plasticity in breast cancer.
Title: CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial-Mesenchymal Plasticity in Breast Cancer.
EGF suppresses specifically CAR signaling mainly through transcriptional regulation and drives the xenobiotic response toward a pregnane X receptor (PXR)-mediated mechanism.
Title: Epidermal Growth Factor Represses Constitutive Androstane Receptor Expression in Primary Human Hepatocytes and Favors Regulation by Pregnane X Receptor.
The results pf this study demonstrated that CAR is expressed by mature neurons throughout the brain. In addition, we propose divergent roles for CAR in immature neurons, during neurogenesis, and at the mature synapse.
Title: Coxsackievirus Adenovirus Receptor Loss Impairs Adult Neurogenesis, Synapse Content, and Hippocampus Plasticity.
data indicate that glycosylation of the extracellular CAR domain has only minor importance for the function of CAR as Coxsackievirus B3 (CVB3) receptor and that the D2 domain is not essential per se but contributes to receptor function by promoting the exposure of the D1 domain on the cell surface
Title: The Coxsackievirus and Adenovirus Receptor: Glycosylation and the Extracellular D2 Domain Are Not Required for Coxsackievirus B3 Infection.
CAR expression has potential as a marker for monitoring and/or predicting the outcome of gene therapy, and increasing its expression levels may contribute to the upregulation of cellular sensitivity towards adenovirus infection.
Title: Loss of coxsackie and adenovirus receptor expression in human colorectal cancer: A potential impact on the efficacy of adenovirus-mediated gene therapy in Chinese Han population.

Submit: New GeneRIF Correction See all GeneRIFs (93)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH15618 (e-PCR)
- UniSTS:86278

PMC64780P1 (e-PCR)
- UniSTS:273419

PMC64780P2 (e-PCR)
- UniSTS:273420

SHGC-143084 (e-PCR)
- UniSTS:171789

RH79230 (e-PCR)
- UniSTS:91949

D8S2278 (e-PCR)
- UniSTS:473906

RH10657 (e-PCR)
- UniSTS:91223

L18426 (e-PCR)
- UniSTS:34648

SHGC-51804 (e-PCR)
- UniSTS:64613

CXADR_1589 (e-PCR)
- UniSTS:277143

CXADR_v557 (e-PCR)
- UniSTS:277143

SHGC-37161 (e-PCR)
- UniSTS:35502

G19855 (e-PCR)
- UniSTS:68853

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables cell adhesive protein binding involved in AV node cell-bundle of His cell communication	IC Inferred by Curator more info	PubMed
enables connexin binding	ISS Inferred from Sequence or Structural Similarity more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables virus receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in AV node cell to bundle of His cell communication	ISS Inferred from Sequence or Structural Similarity more info
involved_in AV node cell-bundle of His cell adhesion involved in cell communication	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell junction organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial structure maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamma-delta T cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in germ cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in homotypic cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of AV node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in transepithelial transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in cell junction	IDA Inferred from Direct Assay more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
is_active_in intercalated disc	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: coxsackievirus and adenovirus receptor

Names: 46 kD coxsackievirus and adenovirus receptor (CAR) protein; CVB3-binding protein; HCVADR; coxsackie virus and adenovirus receptor; coxsackievirus B-adenovirus receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029458.2 RefSeqGene

Range

5002..62059

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001207063.2 → NP_001193992.1 coxsackievirus and adenovirus receptor isoform 2 precursor

See identical proteins and their annotated locations for NP_001193992.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, alternatively referred to as beta or CAR4/7) lacks two consecutive alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform (1).

Source sequence(s)

AP000967, AY072912, CV570985

Consensus CDS

CCDS56205.1

UniProtKB/Swiss-Prot

P78310

Related

ENSP00000383030.1, ENST00000400166.5

Conserved Domains (2) summary

smart00410
Location:29 → 137

IG_like; Immunoglobulin like

pfam07686
Location:23 → 138

V-set; Immunoglobulin V-set domain
NM_001207064.2 → NP_001193993.1 coxsackievirus and adenovirus receptor isoform 3 precursor

See identical proteins and their annotated locations for NP_001193993.1

Status: REVIEWED

Description

Transcript Variant: This variant (3, alternatively referred to as gamma or CAR3/7) lacks three consecutive alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform (1).

Source sequence(s)

AP000967, AY072911, CV570985

Consensus CDS

CCDS56206.1

UniProtKB/Swiss-Prot

P78310

Related

ENSP00000383029.1, ENST00000400165.5

Conserved Domains (2) summary

smart00410
Location:29 → 137

IG_like; Immunoglobulin like

pfam07686
Location:23 → 138

V-set; Immunoglobulin V-set domain
NM_001207065.2 → NP_001193994.1 coxsackievirus and adenovirus receptor isoform 4 precursor

See identical proteins and their annotated locations for NP_001193994.1

Status: REVIEWED

Description

Transcript Variant: This variant (4, alternatively referred to as delta or CAR2/7) lacks four consecutive alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform (1).

Source sequence(s)

AP000967, AY072910, CV570985

Consensus CDS

CCDS56207.1

UniProtKB/Swiss-Prot

P78310

Related

ENSP00000348620.6, ENST00000356275.10
NM_001207066.2 → NP_001193995.1 coxsackievirus and adenovirus receptor isoform 5 precursor

See identical proteins and their annotated locations for NP_001193995.1

Status: REVIEWED

Description

Transcript Variant: This variant (5, alternatively referred to as CAREx8) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AP000967, CV570985

Consensus CDS

CCDS56204.1

UniProtKB/Swiss-Prot

P78310

Related

ENSP00000383033.1, ENST00000400169.1

Conserved Domains (3) summary

smart00410
Location:155 → 229

IG_like; Immunoglobulin like

cd00096
Location:149 → 153

Ig; Ig strand A' [structural motif]

cd20960
Location:20 → 136

IgV_CAR_like; Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins
NM_001338.5 → NP_001329.1 coxsackievirus and adenovirus receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_001329.1

Status: REVIEWED

Description

Transcript Variant: This variant (1, alternatively referred to as alpha or CAREx7) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK313526, AP000967

Consensus CDS

CCDS33519.1

UniProtKB/Swiss-Prot

B2R8V8, B7WPI3, D3YHP0, O00694, P78310, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4

Related

ENSP00000284878.7, ENST00000284878.12

Conserved Domains (2) summary

smart00409
Location:155 → 229

IG; Immunoglobulin

cd20960
Location:20 → 136

IgV_CAR_like; Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000021.9 Reference GRCh38.p14 Primary Assembly

Range

17513043..17636262

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011529476.3 → XP_011527778.1 coxsackievirus and adenovirus receptor isoform X1

Conserved Domains (3) summary

smart00410
Location:155 → 229

IG_like; Immunoglobulin like

cd00096
Location:149 → 153

Ig; Ig strand A' [structural motif]

cd20960
Location:20 → 136

IgV_CAR_like; Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins
XM_011529478.3 → XP_011527780.1 coxsackievirus and adenovirus receptor isoform X3

Conserved Domains (2) summary

smart00410
Location:29 → 137

IG_like; Immunoglobulin like

pfam07686
Location:23 → 138

V-set; Immunoglobulin V-set domain
XM_011529479.2 → XP_011527781.1 coxsackievirus and adenovirus receptor isoform X4

See identical proteins and their annotated locations for XP_011527781.1

UniProtKB/Swiss-Prot

P78310

Conserved Domains (2) summary

smart00410
Location:29 → 137

IG_like; Immunoglobulin like

pfam07686
Location:23 → 138

V-set; Immunoglobulin V-set domain
XM_011529477.3 → XP_011527779.1 coxsackievirus and adenovirus receptor isoform X2

Conserved Domains (2) summary

smart00410
Location:29 → 137

IG_like; Immunoglobulin like

pfam07686
Location:23 → 138

V-set; Immunoglobulin V-set domain

RNA

XR_001754814.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060945.1 Alternate T2T-CHM13v2.0

Range

15868092..15991279

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054324367.1 → XP_054180342.1 coxsackievirus and adenovirus receptor isoform X3
XM_054324365.1 → XP_054180340.1 coxsackievirus and adenovirus receptor isoform X1
XM_054324368.1 → XP_054180343.1 coxsackievirus and adenovirus receptor isoform X4
XM_054324366.1 → XP_054180341.1 coxsackievirus and adenovirus receptor isoform X2