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C22orf15 chromosome 22 open reading frame 15 [ Homo sapiens (human) ]

Gene ID: 150248, updated on 3-Apr-2024

Summary

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Official Symbol
C22orf15provided by HGNC
Official Full Name
chromosome 22 open reading frame 15provided by HGNC
Primary source
HGNC:HGNC:15558
See related
Ensembl:ENSG00000169314 AllianceGenome:HGNC:15558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
N27C7-3
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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Location:
22q11.23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (23762990..23765863)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (24210184..24213057)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24105177..24108050)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 70 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24087516-24088016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24088017-24088517 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24093057-24093732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18759 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24095085-24095758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24096535-24097035 Neighboring gene V-set pre-B cell surrogate light chain 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24107697-24108496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24108497-24109296 Neighboring gene uncharacterized LOC107985577 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 Neighboring gene matrix metallopeptidase 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24122834-24123832

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A genome annotation-driven approach to cloning the human ORFeome. Collins JE, et al. Genome Biol, 2004. PMID 15461802, Free PMC Article
  2. The DNA sequence of human chromosome 22. Dunham I, et al. Nature, 1999 Dec 2. PMID 10591208
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36561

General protein information

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Preferred Names
uncharacterized protein C22orf15
Names
protein N27C7-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331041.2 → NP_001317970.1  uncharacterized protein C22orf15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP000348, AP000349
    Consensus CDS
    CCDS82698.1
    UniProtKB/TrEMBL
    A0A0G2JR10, F8W7S3
    Related
    ENSP00000305096.5, ENST00000305199.9

  2. NM_001376903.1 → NP_001363832.1  uncharacterized protein C22orf15 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP000348, AP000349
    Consensus CDS
    CCDS93130.1
    UniProtKB/TrEMBL
    A0A0G2JR07
    Related
    ENSP00000372271.3, ENST00000382821.3
    Conserved Domains (1) summary
    pfam15874
    Location:7 → 106
    Il2rg; Putative Interleukin 2 receptor, gamma chain

  3. NM_001376904.1 → NP_001363833.1  uncharacterized protein C22orf15 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AP000348, AP000349
    Conserved Domains (1) summary
    pfam15874
    Location:7 → 106
    Il2rg; Putative Interleukin 2 receptor, gamma chain

  4. NM_001376905.1 → NP_001363834.1  uncharacterized protein C22orf15 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AP000348, AP000349
    Conserved Domains (1) summary
    pfam15874
    Location:7 → 83
    Il2rg; Putative Interleukin 2 receptor, gamma chain

  5. NM_182520.3 → NP_872326.2  uncharacterized protein C22orf15 isoform 1

    See identical proteins and their annotated locations for NP_872326.2

    Status: VALIDATED

    Source sequence(s)
    AP000348, AP000349
    Consensus CDS
    CCDS13814.2
    UniProtKB/Swiss-Prot
    Q6ICJ7, Q8WYQ4
    UniProtKB/TrEMBL
    A0A0G2JR24
    Related
    ENSP00000384965.4, ENST00000402217.8
    Conserved Domains (1) summary
    pfam15874
    Location:2 → 101
    Il2rg; Putative Interleukin 2 receptor, gamma chain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    23762990..23765863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452160.2 → XP_024307928.1  uncharacterized protein C22orf15 isoform X1

    Conserved Domains (1) summary
    pfam15874
    Location:2 → 90
    Il2rg; Putative Interleukin 2 receptor, gamma chain

  2. XM_047441152.1 → XP_047297108.1  uncharacterized protein C22orf15 isoform X5

  3. XM_011529908.3 → XP_011528210.2  uncharacterized protein C22orf15 isoform X3

  4. XM_047441153.1 → XP_047297109.1  uncharacterized protein C22orf15 isoform X7

  5. XM_024452161.2 → XP_024307929.1  uncharacterized protein C22orf15 isoform X2

    Conserved Domains (1) summary
    pfam15874
    Location:2 → 83
    Il2rg; Putative Interleukin 2 receptor, gamma chain

  6. XM_017028612.2 → XP_016884101.1  uncharacterized protein C22orf15 isoform X4

  7. XM_017028618.2 → XP_016884107.1  uncharacterized protein C22orf15 isoform X6

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187633.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    622..2225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    24210184..24213057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325122.1 → XP_054181097.1  uncharacterized protein C22orf15 isoform X1

  2. XM_054325126.1 → XP_054181101.1  uncharacterized protein C22orf15 isoform X5

  3. XM_054325124.1 → XP_054181099.1  uncharacterized protein C22orf15 isoform X3

  4. XM_054325128.1 → XP_054181103.1  uncharacterized protein C22orf15 isoform X7

  5. XM_054325123.1 → XP_054181098.1  uncharacterized protein C22orf15 isoform X2

  6. XM_054325125.1 → XP_054181100.1  uncharacterized protein C22orf15 isoform X4

  7. XM_054325127.1 → XP_054181102.1  uncharacterized protein C22orf15 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WYQ4.1 GenPept UniProtKB/Swiss-Prot:Q8WYQ4

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