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GNAS-AS1 GNAS antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 149775, updated on 27-Jan-2024

Summary

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Official Symbol
GNAS-AS1provided by HGNC
Official Full Name
GNAS antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:24872
See related
Ensembl:ENSG00000235590 MIM:610540; AllianceGenome:HGNC:24872
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SANG; GNASAS; NESPAS; GNAS-AS; GNAS1AS; NESP-AS; NCRNA00075
Summary
This gene produces a paternally-imprinted antisense RNA transcript that helps regulate the GNAS complex locus, which encodes the alpha subunit of the stimulatory G protein. Defects in this gene are a cause of pseudohypoparathyroidism type Ib.[provided by RefSeq, Jun 2010]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See GNAS-AS1 in Genome Data Viewer
Location:
20q13.32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (58818918..58850902, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (60601516..60634021, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (57393973..57425958, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene microRNA 296 Neighboring gene microRNA 298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18178 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:57429646-57430522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:57430523-57431398 Neighboring gene GNAS complex locus Neighboring gene uncharacterized LOC101927932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13080 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13084 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:57470438-57471032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:57471033-57471626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:57474225-57474776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18180 Neighboring gene uncharacterized LOC107985382 Neighboring gene small integral membrane protein 30-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The lncRNA, Nespas, Is Associated with Osteoarthritis Progression and Serves as a Potential New Prognostic Biomarker. Park S, et al. Cartilage, 2019 Apr. PMID 28805067, Free PMC Article
  2. Genome-wide DNA methylation analysis of pseudohypoparathyroidism patients with GNAS imprinting defects. Rochtus A, et al. Clin Epigenetics, 2016. PMID 26819647, Free PMC Article
  3. Methylation and transcripts expression at the imprinted GNAS locus in human embryonic and induced pluripotent stem cells and their derivatives. Grybek V, et al. Stem Cell Reports, 2014 Sep 9. PMID 25241742, Free PMC Article
  4. LncRNA GNAS-AS1 facilitates ER+ breast cancer cells progression by promoting M2 macrophage polarization via regulating miR-433-3p/GATA3 axis. Liu SQ, et al. Biosci Rep, 2020 Jul 31. PMID 32538432, Free PMC Article
  5. GNAS-AS1/miR-4319/NECAB3 axis promotes migration and invasion of non-small cell lung cancer cells by altering macrophage polarization. Li Z, et al. Funct Integr Genomics, 2020 Jan. PMID 31267263

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA GNAS-AS1 facilitates ER+ breast cancer cells progression by promoting M2 macrophage polarization via regulating miR-433-3p/GATA3 axis.
    Title: LncRNA GNAS-AS1 facilitates ER+ breast cancer cells progression by promoting M2 macrophage polarization via regulating miR-433-3p/GATA3 axis.
  2. GNAS-AS1/miR-4319/NECAB3 axis promotes tumor progression of non-small cell lung cancer by altering macrophage polarization.
    Title: GNAS-AS1/miR-4319/NECAB3 axis promotes migration and invasion of non-small cell lung cancer cells by altering macrophage polarization.
  3. We suggest that elevated Nespas level in osteoarthritis are associated with osteoarthritis pathogenesis by suppressing miRs targeting ACSL6 and subsequent ACSL6 upregulation.
    Title: The lncRNA, Nespas, Is Associated with Osteoarthritis Progression and Serves as a Potential New Prognostic Biomarker.
  4. GNASAS gene encodes an antisense GNAS transcript that is expressed only from the paternal allele.
    Title: An imprinted antisense transcript at the human GNAS1 locus.
  5. Data show that of IL10, LEP, ABCA1, GNASAS and MEG3 was higher among individuals who were periconceptionally exposed to the famine compared with their unexposed same-sex siblings.
    Title: DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Pseudohypoparathyroidism type 1B
MedGen: C1864100 OMIM: 603233 GeneReviews: Disorders of GNAS Inactivation
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EBI GWAS Catalog

Description
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • GNAS antisense RNA 1 (non-protein coding)
  • GNAS1 antisense

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021433.1 RefSeqGene

    Range
    5001..36986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1051

RNA

  1. NR_002785.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132655
    Related
    ENST00000424094.6

  2. NR_185847.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132655

  3. NR_185848.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132655

  4. NR_185849.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132655
    Related
    ENST00000685926.2

  5. NR_190183.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132655

  6. NR_190184.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132655

  7. NR_190185.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132655

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    58818918..58850902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    60601516..60634021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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