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H2-Eb1 histocompatibility 2, class II antigen E beta [ Mus musculus (house mouse) ]

Gene ID: 14969, updated on 2-Nov-2024

Summary

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Official Symbol
H2-Eb1provided by MGI
Official Full Name
histocompatibility 2, class II antigen E betaprovided by MGI
Primary source
MGI:MGI:95901
See related
Ensembl:ENSMUSG00000060586 AllianceGenome:MGI:95901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eb; Ia4; H2Eb; Ia-4; H-2Eb
Summary
Predicted to enable several functions, including MHC class II receptor activity; peptide antigen binding activity; and signaling receptor binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II. Predicted to be located in external side of plasma membrane and immunological synapse. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Is expressed in lung. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and sarcoidosis (multiple). Orthologous to several human genes including HLA-DRB5 (major histocompatibility complex, class II, DR beta 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 375.3), large intestine adult (RPKM 229.1) and 12 other tissues See more
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Genomic context

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See H2-Eb1 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34524841..34535648)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34305867..34316674)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8669 Neighboring gene histocompatibility 2, class II antigen A, beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E1194 Neighboring gene histocompatibility 2, class II antigen A, alpha Neighboring gene STARR-positive B cell enhancer ABC_E2485 Neighboring gene STARR-positive B cell enhancer ABC_E397 Neighboring gene STARR-positive B cell enhancer ABC_E1505 Neighboring gene STARR-positive B cell enhancer ABC_E1940 Neighboring gene STARR-positive B cell enhancer ABC_E957 Neighboring gene STARR-seq mESC enhancer starr_42428 Neighboring gene STARR-positive B cell enhancer ABC_E8670 Neighboring gene STARR-positive B cell enhancer ABC_E8919 Neighboring gene histocompatibility 2, class II antigen E beta2 Neighboring gene STARR-seq mESC enhancer starr_42429 Neighboring gene histocompatibility 2, class II antigen E alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sequence analysis of MHC class II Eb cDNAs from H2r and H2p haplotypes. Wei BY, et al. Immunogenetics, 1996. PMID 8662092
  2. A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes. Murphy DB, et al. J Exp Med, 1976 Sep 1. PMID 1085338, Free PMC Article
  3. Multiple sites of crossing over within the Eb recombinational hotspot in the mouse. Bryda EC, et al. Mamm Genome, 1992. PMID 1347471
  4. Interaction of H-2Eb with an IAP retrotransposon in the A20/2J B cell lymphoma. Malstrom CE, et al. Immunogenetics, 1992. PMID 1353478
  5. Structural and genetic properties of the Eb recombinational hotspot in the mouse. Zimmerer EJ, et al. Immunogenetics, 1991. PMID 1847899

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. may play an important role in regulating Th1/Th2 balance during the pathogenesis of allergic rhinitis
    Title: H2-EB1 Molecule Alleviates Allergic Rhinitis Symptoms of H2-Eb1 Knockout Mice.
  2. Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-A(k) NOD mice.
    Title: Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-A(k) NOD mice.
  3. H2-Eb1 expression was significantly upregulated in the nasal mucosa of our successfully established allergic rhinitis mouse model
    Title: H2-Eb1 expression is upregulated in the nasal mucosa of allergic rhinitis.
  4. Data demonstrate that the presence of distinct forms of MHC-II with plasma membrane lipid rafts is required for MHC-II aggregation in APCs.
    Title: Distinct MHC class II molecules are associated on the dendritic cell surface in cholesterol-dependent membrane microdomains.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC163794, MGC163796

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CD4 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MHC class II receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
  
enables polysaccharide binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptide antigen assembly with MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MHC class II protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
H-2 class II histocompatibility antigen, I-E beta chain
Names
I-E beta MHC class II
MHC H2-IE-beta cell surface glycoprotein
MHC class II IE-b
cell surface glycoprotein
histocompatibility 2, class II antigen E beta, promoter 1
major histocompatibility complex H-2E beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010382.2 → NP_034512.2  H-2 class II histocompatibility antigen, I-E beta chain precursor

    See identical proteins and their annotated locations for NP_034512.2

    Status: VALIDATED

    Source sequence(s)
    AK160485, BY202562, CAAA01111730
    Consensus CDS
    CCDS37584.1
    UniProtKB/Swiss-Prot
    O78226, P04230
    UniProtKB/TrEMBL
    F6VX29, O78196
    Related
    ENSMUSP00000158533.2, ENSMUST00000235530.2
    Conserved Domains (2) summary
    pfam00969
    Location:40 → 114
    MHC_II_beta; Class II histocompatibility antigen, beta domain
    cl11960
    Location:124 → 217
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34524841..34535648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04230.1 GenPept UniProtKB/Swiss-Prot:P04230
P04231.1 GenPept UniProtKB/Swiss-Prot:P04231
P18468.1 GenPept UniProtKB/Swiss-Prot:P18468
P18469.1 GenPept UniProtKB/Swiss-Prot:P18469
P20040.1 GenPept UniProtKB/Swiss-Prot:P20040

Gene LinkOut

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