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H2-Ea-ps histocompatibility 2, class II antigen E alpha, pseudogene [ Mus musculus (house mouse) ]

Gene ID: 14968, discontinued on 26-Aug-2011

Summary

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Official Symbol
H2-Ea-psprovided by MGI
Official Full Name
histocompatibility 2, class II antigen E alpha, pseudogeneprovided by MGI
Primary source
MGI:MGI:95900
Gene type
protein coding
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ia3; Ia-3; H-2Ea; H2-Ea; I-Ealpha; E-alpha-f
Summary
This locus belongs to the class II major histocompatibility complex (MHC) family of genes, which encode immune response (Ia) antigens that function in the T-cell-dependent immune response. This family member has multiple haplotypes, some of which result in the production of an E-alpha subunit that combines with an E-beta subunit to form a functional E complex at the cell surface. Other haplotypes, including that of the reference genome allele, contain mutations and they thus represent polymorphic pseudogenes that do not produce functional products. These mutations include frameshifting indels, nonsense mutations, and deletions of larger regions. The reference genome haplotype contains a deletion at the 5' end of the gene, including the core promoter region and the transcription start site, and therefore no transcripts result from this haplotype. [provided by RefSeq, Aug 2010]
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Genomic context

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Location:
17 B1; 17 18.7 cM

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Clone Names

  • MGC117888

General protein information

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Names
histocompatibility 2, class II antigen E alpha, pseudogene
H-2 class II histocompatibility antigen, E-D alpha chain
H-2 class II histocompatibility antigen, E-K alpha chain
H-2 class II histocompatibility antigen, E-U alpha chain
H2-IE-alpha
I-E alpha MHC class II
MHC class II antigen E alpha
MHC class II protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01904.2 GenPept UniProtKB/Swiss-Prot:P01904
P04224.1 GenPept UniProtKB/Swiss-Prot:P04224
P14439.1 GenPept UniProtKB/Swiss-Prot:P14439

Gene LinkOut

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