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H2-Ab1 histocompatibility 2, class II antigen A, beta 1 [ Mus musculus (house mouse) ]

Gene ID: 14961, updated on 12-Nov-2024

Summary

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Official Symbol
H2-Ab1provided by MGI
Official Full Name
histocompatibility 2, class II antigen A, beta 1provided by MGI
Primary source
MGI:MGI:103070
See related
Ensembl:ENSMUSG00000073421 AllianceGenome:MGI:103070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IAb; Ia2; Ia-2; Abeta; H-2Ab; H2-Ab; Rmcs1; I-Abeta
Summary
Enables peptide antigen binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and immune response. Located in Golgi apparatus; endosome; and external side of plasma membrane. Part of MHC class II protein complex. Is expressed in several structures, including adipose tissue; bone; hemolymphoid system; liver; and lung. Used to study dilated cardiomyopathy and myocarditis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to several human genes including HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 2279.6), large intestine adult (RPKM 1316.2) and 12 other tissues See more
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Genomic context

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See H2-Ab1 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34482201..34488392)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34263227..34269418)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4209 Neighboring gene STARR-positive B cell enhancer ABC_E4210 Neighboring gene histocompatibility 2, O region beta locus Neighboring gene STARR-positive B cell enhancer ABC_E7524 Neighboring gene predicted gene 20506 Neighboring gene STARR-positive B cell enhancer ABC_E768 Neighboring gene STARR-positive B cell enhancer ABC_E1193 Neighboring gene STARR-positive B cell enhancer ABC_E8669 Neighboring gene STARR-positive B cell enhancer ABC_E1194 Neighboring gene histocompatibility 2, class II antigen A, alpha Neighboring gene STARR-positive B cell enhancer ABC_E2485 Neighboring gene STARR-positive B cell enhancer ABC_E397 Neighboring gene STARR-positive B cell enhancer ABC_E1505 Neighboring gene STARR-positive B cell enhancer ABC_E1940 Neighboring gene STARR-positive B cell enhancer ABC_E957 Neighboring gene STARR-seq mESC enhancer starr_42428 Neighboring gene histocompatibility 2, class II antigen E beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Epitope affinity for MHC class I determines helper requirement for CTL priming. Franco A, et al. Nat Immunol, 2000 Aug. PMID 11248807
  2. Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice. Liu J, et al. Diabetes, 1999 Mar. PMID 10078545
  3. Chronic modulation of the TCR repertoire in the lymphoid periphery. Blish CA, et al. J Immunol, 1999 Mar 15. PMID 10092762
  4. Experimental autoimmune encephalomyelitis induced in B6.C-H-2bm12 mice by myelin oligodendrocyte glycoprotein: effect of MHC class II mutation on immunodominant epitope selection and fine epitope specificity of encephalitogenic T cells. Mendel I, et al. J Neuroimmunol, 1999 Apr 1. PMID 10227420
  5. Short ragweed allergen induces eosinophilic lung disease in HLA-DQ transgenic mice. Chapoval SP, et al. J Clin Invest, 1999 Jun. PMID 10377177, Free PMC Article

See all (893) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gut microbiota regulates blood-cerebrospinal fluid barrier function and Abeta pathology.
    Title: Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology.
  2. Two structurally defined Abeta polymorphs promote different pathological changes in susceptible mice.
    Title: Two structurally defined Aβ polymorphs promote different pathological changes in susceptible mice.
  3. Both the modest nature of the TLR2-mediated inflammatory response and the modulation of MHC-II expression by Brucella abortus may contribute to bacterial survival in alveolar macrophages.
    Title: Key role of Toll-like receptor 2 in the inflammatory response and major histocompatibility complex class ii downregulation in Brucella abortus-infected alveolar macrophages.
  4. Murine CD4+ T cells specific for Salmonella peptide/class II histocompatibility ligands are numerically stable for more than a year after initial oral infection with Salmonella.
    Title: CD4+ T cell persistence and function after infection are maintained by low-level peptide:MHC class II presentation.
  5. T helper cells with captured peptide-MHC-II (H2-Ab1) antigen molecules become effector cells that manifest better recall responses, and regulatory (Treg) cells with captured ligands exhibit enhanced suppression activity.
    Title: Presentation of acquired peptide-MHC class II ligands by CD4+ regulatory T cells or helper cells differentially regulates antigen-specific CD4+ T cell response.
  6. Data demonstrate that the presence of distinct forms of MHC-II with plasma membrane lipid rafts is required for MHC-II aggregation in APCs.
    Title: Distinct MHC class II molecules are associated on the dendritic cell surface in cholesterol-dependent membrane microdomains.
  7. deletion of IA-2 and IA-2beta, structural proteins of secretory vesicles and modulators of neuroendocrine secretion, has a profound effect on the circadian system
    Title: Deletion of the secretory vesicle proteins IA-2 and IA-2beta disrupts circadian rhythms of cardiovascular and physical activity.
  8. Phogrin and IA-2 function as essential regulators of autocrine insulin action in pancreatic beta-cells.
    Title: Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth.
  9. The microenvironment of I-Ab molecules that acquired their antigenic cargo in endosomes may be important for polarized tubulation of class II-positive compartments in antigen-presenting dendritic cells.
    Title: Requirements for T cell-polarized tubulation of class II+ compartments in dendritic cells.
  10. crystal structure of the murine class II MHC molecule I-A(b) in complex with human CLIP at 2.15A resolution
    Title: Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide antigen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within antigen processing and presentation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within antigen processing and presentation of peptide antigen IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptide antigen assembly with MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MHC class II protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in multivesicular body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histocompatibility 2, class II antigen A, beta 1
Names
H-2 class II histocompatibility antigen, A beta chain
MHC class II H2-IA-beta-psi
histocompatibility 2, class II antigen A, beta, promoter 1
major histocompatibility complex class II beta chain
response to metastatic cancers 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207105.3 → NP_996988.2  histocompatibility 2, class II antigen A, beta 1 precursor

    See identical proteins and their annotated locations for NP_996988.2

    Status: VALIDATED

    Source sequence(s)
    AK077436, BB056841, BY205244, CK330363
    Consensus CDS
    CCDS37583.1
    UniProtKB/Swiss-Prot
    P14483
    UniProtKB/TrEMBL
    Q3TD53, Q8BPA0
    Related
    ENSMUSP00000041008.6, ENSMUST00000040828.7
    Conserved Domains (2) summary
    cd05766
    Location:125 → 218
    IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain
    pfam00969
    Location:40 → 111
    MHC_II_beta; Class II histocompatibility antigen, beta domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34482201..34488392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01921.1 GenPept UniProtKB/Swiss-Prot:P01921
P06342.1 GenPept UniProtKB/Swiss-Prot:P06342
P06343.1 GenPept UniProtKB/Swiss-Prot:P06343
P06345.1 GenPept UniProtKB/Swiss-Prot:P06345
P06346.1 GenPept UniProtKB/Swiss-Prot:P06346
P14483.1 GenPept UniProtKB/Swiss-Prot:P14483

Gene LinkOut

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