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L Polymerase (L) [ Human respiratory syncytial virus A ]

Gene ID: 1494467, updated on 1-Aug-2024

Summary

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Gene symbol
L
Gene description
Polymerase (L)
Locus tag
Rsvgp10
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human respiratory syncytial virus A (strain: S2 ts1C)
Lineage
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Pneumoviridae; Orthopneumovirus; Orthopneumovirus hominis
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Genomic context

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Sequence:
NC_001803.1 (8460..15037)

NC_001803.1Genomic Context describing neighboring genes Neighboring gene Attachment glycoprotein (G) Neighboring gene Fusion protein (F) Neighboring gene matrix (M2/22K) Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001803.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structures of the promoter-bound respiratory syncytial virus polymerase. Cao D, et al. Nature, 2024 Jan. PMID 38123676, Free PMC Article
  2. Respiratory syncytial virus polymerase can initiate transcription from position 3 of the leader promoter. Tremaglio CZ, et al. J Virol, 2013 Mar. PMID 23283954, Free PMC Article
  3. The respiratory syncytial virus polymerase has multiple RNA synthesis activities at the promoter. Noton SL, et al. PLoS Pathog, 2012. PMID 23093940, Free PMC Article
  4. Identification of mutations contributing to the reduced virulence of a modified strain of respiratory syncytial virus. Tolley KP, et al. Vaccine, 1996 Dec. PMID 9032893

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structures of the promoter-bound respiratory syncytial virus polymerase.
    Title: Structures of the promoter-bound respiratory syncytial virus polymerase.
  2. Taken together, these data suggest a new model for initiation of sequential transcription of the respiratory syncytial virus genes, whereby the RNA-dependent RNA polymerase initiates the process from a gene start-like sequence at position +3 of the Le.
    Title: Respiratory syncytial virus polymerase can initiate transcription from position 3 of the leader promoter.
  3. findings indicate that RSV polymerase-promoter interactions are more complex than previously thought and suggest that there might be sophisticated mechanisms for regulating promoter activity during infection
    Title: The respiratory syncytial virus polymerase has multiple RNA synthesis activities at the promoter.
Submit: New GeneRIF Correction

General gene information

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  • overlap

General protein information

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Preferred Names
Polymerase (L)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001803.1 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_044598.1 Polymerase (L) [Human respiratory syncytial virus A]

    See identical proteins and their annotated locations for NP_044598.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    O09721, O12537, O12826, Q76TK7, Q82027
    Conserved Domains (2) summary
    TIGR04198
    Location:1285 → 2161
    paramyx_RNAcap; mRNA capping enzyme, paramyxovirus family
    pfam00946
    Location:16 → 1179
    Mononeg_RNA_pol; Mononegavirales RNA dependent RNA polymerase
Protein Accession Links
GenPept Link UniProtKB Link
AAC57039.1

Gene LinkOut

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