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POLY polyprotein [ Dengue virus 2 ]

Gene ID: 1494449, updated on 5-Feb-2024

Summary

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Gene symbol
POLY
Gene description
polyprotein
Locus tag
DENV_gp1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Dengue virus 2 (strain: 16681)
Lineage
Viruses; Riboviria; Flaviviridae; Flavivirus
Also known as
polyprotein gene
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Genomic context

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Sequence:
NC_001474.2 (97..10272)

NC_001474.2Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001474.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dengue virus NS5 degrades ERC1 during infection to antagonize NF-kB activation. Gonzalez Lopez Ledesma MM, et al. Proc Natl Acad Sci U S A, 2023 Jun 6. PMID 37252973, Free PMC Article
  2. The Dengue virus protease NS2B3 cleaves cyclic GMP-AMP synthase to suppress cGAS activation. Bhattacharya M, et al. J Biol Chem, 2023 Mar. PMID 36754281, Free PMC Article
  3. Determinants in Nonstructural Protein 4A of Dengue Virus Required for RNA Replication and Replication Organelle Biogenesis. Cortese M, et al. J Virol, 2021 Oct 13. PMID 34379504, Free PMC Article
  4. Novel insights into the function of an N-terminal region of DENV2 NS4B for the optimal helicase activity of NS3. Lu H, et al. Virus Res, 2021 Apr 2. PMID 33485995
  5. Mutations in the cytoplasmic domain of dengue virus NS4A affect virus fitness and interactions with other non-structural proteins. Tan MJA, et al. J Gen Virol, 2020 Sep. PMID 32589122

See all (280) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of a critical role for ZIKV capsid alpha3 in virus assembly and its genetic interaction with M protein.
    Title: Identification of a critical role for ZIKV capsid α3 in virus assembly and its genetic interaction with M protein.
  2. DENV-2 NS1 promotes AMPK-LKB1 interaction to activate AMPK/ERK/mTOR signaling pathway to induce autophagy.
    Title: DENV-2 NS1 promotes AMPK-LKB1 interaction to activate AMPK/ERK/mTOR signaling pathway to induce autophagy.
  3. Dengue virus NS5 degrades ERC1 during infection to antagonize NF-kB activation.
    Title: Dengue virus NS5 degrades ERC1 during infection to antagonize NF-kB activation.
  4. The Dengue virus protease NS2B3 cleaves cyclic GMP-AMP synthase to suppress cGAS activation.
    Title: The Dengue virus protease NS2B3 cleaves cyclic GMP-AMP synthase to suppress cGAS activation.
  5. Novel insights into the function of an N-terminal region of DENV2 NS4B for the optimal helicase activity of NS3.
    Title: Novel insights into the function of an N-terminal region of DENV2 NS4B for the optimal helicase activity of NS3.
  6. Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry.
    Title: Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry.
  7. Dengue and Zika Virus Capsid Proteins Contain a Common PEX19-Binding Motif.
    Title: Dengue and Zika Virus Capsid Proteins Contain a Common PEX19-Binding Motif.
  8. Determinants in Nonstructural Protein 4A of Dengue Virus Required for RNA Replication and Replication Organelle Biogenesis.
    Title: Determinants in Nonstructural Protein 4A of Dengue Virus Required for RNA Replication and Replication Organelle Biogenesis.
  9. Dengue and Zika virus capsid proteins bind to membranes and self-assemble into liquid droplets with nucleic acids.
    Title: Dengue and Zika virus capsid proteins bind to membranes and self-assemble into liquid droplets with nucleic acids.
  10. Mutations in the cytoplasmic domain of dengue virus NS4A affect virus fitness and interactions with other non-structural proteins.
    Title: Mutations in the cytoplasmic domain of dengue virus NS4A affect virus fitness and interactions with other non-structural proteins.
Submit: New GeneRIF Correction See all GeneRIFs (113)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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regulatory

  • Loc: 134-144 regulatory_class = other

stem_loop

  • Loc: 116-132

General protein information

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Preferred Names
polyprotein
Names
anchored capsid protein ancC
capsid protein C
membrane glycoprotein precursor prM
membrane glycoprotein M
envelope protein E
nonstructural protein NS1
nonstructural protein NS2A
nonstructural protein NS2B
nonstructural protein NS3
nonstructural protein NS4A
protein 2K
nonstructural protein NS4B
RNA-dependent RNA polymerase NS5
protein pr
NP_056776.2
  • contains structural proteins, C-prM/M-E and non-structural proteins, NS1-NS2A/B-NS3-NS4A/B-NS5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001474.2 Reference assembly

    Range
    97..10272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_056776.2 polyprotein [Dengue virus 2]

    See identical proteins and their annotated locations for NP_056776.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A173DS53, D0EPS0, O09234
    Conserved Domains (17) summary
    cd12149
    Location:585 → 674
    Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
    TIGR04240
    Location:679 → 775
    flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
    smart00487
    Location:1657 → 1800
    DEXDc; DEAD-like helicases superfamily
    pfam01003
    Location:5 → 114
    Flavi_capsid; Flavivirus capsid protein C
    pfam00869
    Location:282 → 576
    Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains
    pfam00948
    Location:777 → 1130
    Flavi_NS1; Flavivirus non-structural Protein NS1
    pfam00949
    Location:1494 → 1642
    Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
    pfam00972
    Location:2742 → 3380
    Flavi_NS5; Flavivirus RNA-directed RNA polymerase
    pfam01002
    Location:1349 → 1475
    Flavi_NS2B; Flavivirus non-structural protein NS2B
    pfam01004
    Location:207 → 280
    Flavi_M; Flavivirus envelope glycoprotein M
    pfam01005
    Location:1138 → 1342
    Flavi_NS2A; Flavivirus non-structural protein NS2A
    pfam01349
    Location:2244 → 2484
    Flavi_NS4B; Flavivirus non-structural protein NS4B
    pfam01350
    Location:2098 → 2240
    Flavi_NS4A; Flavivirus non-structural protein NS4A
    pfam01570
    Location:126 → 204
    Flavi_propep; Flavivirus polyprotein propeptide
    pfam01728
    Location:2546 → 2713
    FtsJ; FtsJ-like methyltransferase
    pfam07652
    Location:1660 → 1805
    Flavi_DEAD; Flavivirus DEAD domain
    cl21455
    Location:1830 → 1939
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NP_739581.2 anchored capsid protein ancC

    UniProtKB/TrEMBL
    A0A0K0WW33, I4AY88
    Conserved Domains (1) summary
    pfam01003
    Location:5 → 114
    Flavi_capsid; Flavivirus capsid protein C

  3. NP_739591.2 capsid protein C

    UniProtKB/TrEMBL
    A0A0K0WW33, W0GCK5
    Conserved Domains (1) summary
    pfam01003
    Location:5 → 100
    Flavi_capsid; Flavivirus capsid protein C

  4. NP_739582.2 membrane glycoprotein precursor prM

    UniProtKB/TrEMBL
    Q66346
    Conserved Domains (2) summary
    pfam01004
    Location:93 → 166
    Flavi_M; Flavivirus envelope glycoprotein M
    pfam01570
    Location:12 → 90
    Flavi_propep; Flavivirus polyprotein propeptide

  5. NP_739592.2 membrane glycoprotein M

    Conserved Domains (1) summary
    cl03065
    Location:2 → 75
    Flavi_M; Flavivirus envelope glycoprotein M

  6. NP_739583.2 envelope protein E

    UniProtKB/TrEMBL
    A0A2H5CUH3, Q88631
    Conserved Domains (3) summary
    cd12149
    Location:305 → 394
    Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
    TIGR04240
    Location:399 → 495
    flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
    pfam00869
    Location:2 → 296
    Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains

  7. NP_739584.2 nonstructural protein NS1

    UniProtKB/TrEMBL
    H6UUY8, Q04040
    Conserved Domains (1) summary
    pfam00948
    Location:2 → 352
    Flavi_NS1; Flavivirus non-structural Protein NS1

  8. NP_739585.2 nonstructural protein NS2A

    UniProtKB/TrEMBL
    A0A3Q9SYF8, A0A3T0NKL3, A0A3T0NKP0
    Conserved Domains (1) summary
    pfam01005
    Location:11 → 215
    Flavi_NS2A; Flavivirus non-structural protein NS2A

  9. NP_739586.2 nonstructural protein NS2B

    UniProtKB/TrEMBL
    A0A1L2BPD3
    Conserved Domains (1) summary
    pfam01002
    Location:4 → 130
    Flavi_NS2B; Flavivirus non-structural protein NS2B

  10. NP_739587.2 nonstructural protein NS3

    Conserved Domains (4) summary
    smart00487
    Location:182 → 325
    DEXDc; DEAD-like helicases superfamily
    pfam00949
    Location:19 → 167
    Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
    pfam07652
    Location:185 → 330
    Flavi_DEAD; Flavivirus DEAD domain
    cl21455
    Location:355 → 464
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  11. NP_739588.2 nonstructural protein NS4A

    UniProtKB/TrEMBL
    V5TI10
    Conserved Domains (1) summary
    pfam01350
    Location:5 → 127
    Flavi_NS4A; Flavivirus non-structural protein NS4A

  12. NP_739593.2 protein 2K

  13. NP_739589.2 nonstructural protein NS4B

    UniProtKB/TrEMBL
    V5THH8
    Conserved Domains (1) summary
    pfam01349
    Location:1 → 241
    Flavi_NS4B; Flavivirus non-structural protein NS4B

  14. NP_739590.2 RNA-dependent RNA polymerase NS5

    Conserved Domains (2) summary
    pfam00972
    Location:251 → 889
    Flavi_NS5; Flavivirus RNA-directed RNA polymerase
    pfam01728
    Location:55 → 222
    FtsJ; FtsJ-like methyltransferase

  15. YP_009164954.1 protein pr

    Conserved Domains (1) summary
    pfam01570
    Location:12 → 90
    Flavi_propep; Flavivirus polyprotein propeptide
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
AAB58782.1

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