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VSIVgp4 glycoprotein (G protein) precursor [ Vesicular stomatitis Indiana virus ]

Gene ID: 1489834, updated on 18-Aug-2023

Summary

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Gene symbol
VSIVgp4
Gene description
glycoprotein (G protein) precursor
Locus tag
VSIVgp4
Gene type
protein coding
RNA name
G mRNA
RefSeq status
PROVISIONAL
Organism
Vesicular stomatitis Indiana virus
Lineage
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Rhabdoviridae; Vesiculovirus
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Genomic context

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Sequence:
NC_001560.1 (3049..4713)

NC_001560.1Genomic Context describing neighboring genes Neighboring gene NS protein;protein C' Neighboring gene matrix (M) protein Neighboring gene polymerase (L protein)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001560.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vesicular stomatitis virus G protein transmembrane region is crucial for the hemi-fusion to full fusion transition. Ci Y, et al. Sci Rep, 2018 Jul 13. PMID 30006542, Free PMC Article
  2. Structural intermediates in the fusion-associated transition of vesiculovirus glycoprotein. Baquero E, et al. EMBO J, 2017 Mar 1. PMID 28188244, Free PMC Article
  3. Vesicular stomatitis virus glycoprotein is anchored in the viral membrane by a hydrophobic domain near the COOH terminus. Rose JK, et al. Proc Natl Acad Sci U S A, 1980 Jul. PMID 6253998, Free PMC Article
  4. Characterization of pH-sensitive molecular switches that trigger the structural transition of vesicular stomatitis virus glycoprotein from the postfusion state toward the prefusion state. Ferlin A, et al. J Virol, 2014 Nov. PMID 25210175, Free PMC Article
  5. Biological differences between vesicular stomatitis virus Indiana and New Jersey serotype glycoproteins: identification of amino acid residues modulating pH-dependent infectivity. Martinez I, et al. J Virol, 2005 Mar. PMID 15731252, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study reports here that the transmembrane (TM) region was important for vesicular stomatitis virus G (VSV G) protein mediated membrane fusion and viral infection. Replacement of the TM region impaired the fusion function of VSV G and blocked the fusion process at the hemi-fusion stage.
    Title: Vesicular stomatitis virus G protein transmembrane region is crucial for the hemi-fusion to full fusion transition.
  2. Vesicular stomatitis virus G protein complex with two distinct cysteine-rich domains (CR2 and CR3) of LDL-R.
    Title: Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein.
  3. This work reveals the range of glycoprotein G structural changes and suggests that G monomers can re-associate, through antiparallel interactions between fusion domains, into dimers that play a role at some early stage of the fusion process.
    Title: Structural intermediates in the fusion-associated transition of vesiculovirus glycoprotein.
  4. NSF deficiency in HeLa cells barely affected cell viability, anterograde trafficking of vesicular stomatitis virus glycoprotein G and transferrin endocytosis.
    Title: Differential requirement for N-ethylmaleimide-sensitive factor in endosomal trafficking of transferrin receptor from anterograde trafficking of vesicular stomatitis virus glycoprotein G.
  5. MARCH8 is highly expressed in terminally differentiated myeloid cells, and that it is a potent antiviral protein that targets viral envelope glycoproteins and reduces their incorporation into virions.
    Title: MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins.
  6. Pepscan mapping of autophagy-inducing linear determinants of glycoproteins viral hemorrhagic septicemia virus and glycoproteins vesicular stomatitis virus showed that peptides located in their fusion domains induce autophagy
    Title: Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules.
  7. Overall, these results showed that the HIV Env membrane-proximal external region could functionally substitute for the vesicular stomatitis virus G-stem region implying that both perform similar functions even though they are from unrelated viruses.
    Title: The stem of vesicular stomatitis virus G can be replaced with the HIV-1 Env membrane-proximal external region without loss of G function or membrane-proximal external region antigenic properties.
  8. Authors show that D268, located in the segment consisting of residues 264 to 273, which refolds into postfusion helix F during G structural transition, is the major pH sensor while D274, D395, and D393 have additional contributions.
    Title: Characterization of pH-sensitive molecular switches that trigger the structural transition of vesicular stomatitis virus glycoprotein from the postfusion state toward the prefusion state.
  9. Recombinant VSV with RABV-G drives strong expression of transgenes and spreads rapidly from neuron to neuron in only a retrograde manner.
    Title: Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo.
  10. Energetic analyses revealed weakened interaction between Domain IV and the protein core at pH 5, which can be attributed to two pairs of structurally neighboring conserved and differentially protonated residues in the Domain IV-core interface.
    Title: pH-dependent molecular dynamics of vesicular stomatitis virus glycoprotein G.
Submit: New GeneRIF Correction See all GeneRIFs (19)

General gene information

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Homology

General protein information

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Preferred Names
glycoprotein (G protein) precursor
Names
glycoprotein (G protein) mature peptide

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001560.1 Reference assembly

    Range
    3049..4713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_041715.1 glycoprotein (G protein) precursor [Vesicular stomatitis Indiana virus]

    See identical proteins and their annotated locations for NP_041715.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03522
    UniProtKB/TrEMBL
    F8S860
    Conserved Domains (1) summary
    pfam00974
    Location:4 → 487
    Rhabdo_glycop; Rhabdovirus spike glycoprotein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
VGVN.1

Gene LinkOut

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Molecular Biology Databases
Research Materials