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N nucleocapsid protein [ Infectious bronchitis virus ]

Gene ID: 1489745, updated on 18-Aug-2023

Summary

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Gene symbol
N
Gene description
nucleocapsid protein
Locus tag
IBVgp6
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Infectious bronchitis virus (strain: Beaudette)
Lineage
Viruses; Riboviria; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Gammacoronavirus; Igacovirus
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Genomic context

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Sequence:
NC_001451.1 (25873..27102)

NC_001451.1Genomic Context describing neighboring genes Neighboring gene ORF1a polyprotein;ORF1ab polyprotein Neighboring gene spike protein Neighboring gene 3a protein;3b protein;small virion-associated protein Neighboring gene membrane protein Neighboring gene 5a protein;5b protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001451.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of two ATR-dependent phosphorylation sites on coronavirus nucleocapsid protein with nonessential functions in viral replication and infectivity in cultured cells. Fang S, et al. Virology, 2013 Sep. PMID 23849791, Free PMC Article
  2. The cellular interactome of the coronavirus infectious bronchitis virus nucleocapsid protein and functional implications for virus biology. Emmott E, et al. J Virol, 2013 Sep. PMID 23637410, Free PMC Article
  3. Characterisation of the RNA binding properties of the coronavirus infectious bronchitis virus nucleocapsid protein amino-terminal region. Spencer KA, et al. FEBS Lett, 2006 Oct 30. PMID 17052713, Free PMC Article
  4. Three-dimensional reconstruction of the nucleolus using meta-confocal microscopy in cells expressing the coronavirus nucleoprotein. You JH, et al. Adv Exp Med Biol, 2006. PMID 17037551, Free PMC Article
  5. Expression and structural analysis of infectious bronchitis virus nucleoprotein. Spencer KA, et al. Adv Exp Med Biol, 2006. PMID 17037519, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The potential interactome of the N protein was mapped using stable isotope labeling with amino acids in cell culture (SILAC) coupled to a green fluorescent protein-nanotrap pulldown methodology and liquid chromatography-tandem mass spectrometry.
    Title: The cellular interactome of the coronavirus infectious bronchitis virus nucleocapsid protein and functional implications for virus biology.
  2. Authors show that phosphorylation at Thr378 and Ser379 sites is dependent on the ataxia-telangiectasia mutated (ATM) and Rad3-related (ATR), a kinase activated during infectious bronchitis virus replication.
    Title: Identification of two ATR-dependent phosphorylation sites on coronavirus nucleocapsid protein with nonessential functions in viral replication and infectivity in cultured cells.
  3. determination of sequences of N protein genes of IBV isolates in Korea & comparison with those of non-Korean IBV strains
    Title: Variations in the nucleocapsid protein gene of infectious bronchitis viruses isolated in Korea.
  4. analysis of infectious bronchitis virus nucleoprotein
    Title: Expression and structural analysis of infectious bronchitis virus nucleoprotein.
  5. Identification of residues critical for RNA binding on the nucleocapsid surface, and biochemical and genetic evidence that directly links the RNA binding capacity of the coronavirus N protein to the viral infectivity in cultured cells.
    Title: Amino acid residues critical for RNA-binding in the N-terminal domain of the nucleocapsid protein are essential determinants for the infectivity of coronavirus in cultured cells.
  6. The amino-terminal region facilitates long-range non-specific interactions between N protein and viral RNA, thus bringing the RNA into close proximity to N protein allowing specific contacts to form via a 'lure' and 'lock' mechanism.
    Title: Characterisation of the RNA binding properties of the coronavirus infectious bronchitis virus nucleocapsid protein amino-terminal region.
  7. The crystal structure of the IBV-N29-160 fragment at 1.85 A resolution was reported.
    Title: The nucleocapsid protein of coronavirus infectious bronchitis virus: crystal structure of its N-terminal domain and multimerization properties.
  8. analysis of coronavirus nucleoprotein effect on cell nucleolus by confocal microscopy
    Title: Three-dimensional reconstruction of the nucleolus using meta-confocal microscopy in cells expressing the coronavirus nucleoprotein.
  9. Mutations and recombination events could contribute to the genetic diversity of the Italian isolates.
    Title: Phylogenetic analysis of partial S1 and N gene sequences of infectious bronchitis virus isolates from Italy revealed genetic diversity and recombination.
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General gene information

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Homology

General protein information

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Preferred Names
nucleocapsid protein
NP_040838.1
  • ORF for gene 6; label: N

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001451.1 Reference assembly

    Range
    25873..27102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040838.1 nucleocapsid protein [Infectious bronchitis virus]

    See identical proteins and their annotated locations for NP_040838.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P69596, P69597, P69598, Q4ZJS4, Q89902
    UniProtKB/TrEMBL
    B5LSW1
    Conserved Domains (1) summary
    pfam00937
    Location:34 → 341
    Corona_nucleoca; Coronavirus nucleocapsid protein
Nucleotide Protein
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