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POLY polyprotein [ Tick-borne encephalitis virus ]

Gene ID: 1489719, updated on 18-Dec-2023

Summary

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Gene symbol
POLY
Gene description
polyprotein
Locus tag
TBEVgp1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Tick-borne encephalitis virus
Lineage
Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; Amarillovirales; Flaviviridae; Orthoflavivirus; Orthoflavivirus encephalitidis
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Genomic context

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Sequence:
NC_001672.1 (133..10377)

NC_001672.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001672.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Construction and mutagenesis of an artificial bicistronic tick-borne encephalitis virus genome reveals an essential function of the second transmembrane region of protein e in flavivirus assembly. Orlinger KK, et al. J Virol, 2006 Dec. PMID 17035331, Free PMC Article
  2. Genome sequence of tick-borne encephalitis virus (Western subtype) and comparative analysis of nonstructural proteins with other flaviviruses. Mandl CW, et al. Virology, 1989 Nov. PMID 2554575
  3. Sequence of the structural proteins of tick-borne encephalitis virus (western subtype) and comparative analysis with other flaviviruses. Mandl CW, et al. Virology, 1988 Sep. PMID 3413985
  4. The flavivirus 3'-noncoding region: extensive size heterogeneity independent of evolutionary relationships among strains of tick-borne encephalitis virus. Wallner G, et al. Virology, 1995 Oct 20. PMID 7483260
  5. Oligomeric rearrangement of tick-borne encephalitis virus envelope proteins induced by an acidic pH. Allison SL, et al. J Virol, 1995 Feb. PMID 7529335, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.
    Title: Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.
  2. Sterile 20-like kinase 3 promotes tick-borne encephalitis virus assembly by interacting with NS2A and prM and enhancing the NS2A-NS4A association.
    Title: Sterile 20-like kinase 3 promotes tick-borne encephalitis virus assembly by interacting with NS2A and prM and enhancing the NS2A-NS4A association.
  3. Activation of Early Proinflammatory Responses by TBEV NS1 Varies between the Strains of Various Subtypes.
    Title: Activation of Early Proinflammatory Responses by TBEV NS1 Varies between the Strains of Various Subtypes.
  4. Tick-borne encephalitis nonstructural protein NS1 expressed in E. coli retains immunological properties of the native protein.
    Title: Tick-borne encephalitis nonstructural protein NS1 expressed in E. coli retains immunological properties of the native protein.
  5. Crystal structure of a tick-borne flavivirus RNA-dependent RNA polymerase suggests a host adaptation hotspot in RNA viruses.
    Title: Crystal structure of a tick-borne flavivirus RNA-dependent RNA polymerase suggests a host adaptation hotspot in RNA viruses.
  6. study revealed that NS4A is critical for suppressing the phosphorylation and dimerization of STAT1/STAT2 as an IFN-STAT antagonist.
    Title: Tick-borne encephalitis virus NS4A ubiquitination antagonizes type I interferon-stimulated STAT1/2 signalling pathway.
  7. viperin interacted with NS3 of mosquito-borne flaviviruses (ZIKV, Japanese encephalitis virus, and yellow fever virus), only ZIKV was sensitive to the antiviral effect of viperin. This sensitivity correlated with viperin's ability to induce proteasome-dependent degradation of NS3
    Title: Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation.
  8. These findings suggest a critical role for NS5 in stimulating neuronal dysfunction and degeneration following tick-borne encephalitis virus infection.
    Title: A critical determinant of neurological disease associated with highly pathogenic tick-borne flavivirus in mice.
  9. NS2B/3 proteolysis at the C-prM junction of polyprotein is highly membrane dependent.
    Title: NS2B/3 proteolysis at the C-prM junction of the tick-borne encephalitis virus polyprotein is highly membrane dependent.
  10. These findings suggest a role of the positive charge of the C terminus of protein C for budding of the nucleocapsid and further support the notion that tick-borne encephalitis virus protein C is a multifunctional protein.
    Title: Generation and genetic stability of tick-borne encephalitis virus mutants dependent on processing by the foot-and-mouth disease virus 3C protease.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
polyprotein
Names
core protein C
anchored core protein C
PreM protein
matrix protein M
envelope protein
non-structural protein NS1
non-structural protein NS2a
non-structural protein NS2b
non-structural protein NS3
non-structural protein NS4a
2K protein
non-structural protein NS4b
RNA-dependent RNA polymerase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001672.1 Reference assembly

    Range
    133..10377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_043135.1 polyprotein [Tick-borne encephalitis virus]

    See identical proteins and their annotated locations for NP_043135.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P14336, Q88493
    UniProtKB/TrEMBL
    A0A4Y5RS30
    Conserved Domains (15) summary
    cd12149
    Location:591 → 675
    Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
    TIGR04240
    Location:680 → 776
    flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
    pfam00948
    Location:779 → 1131
    Flavi_NS1; Flavivirus non-structural Protein NS1
    pfam01005
    Location:1141 → 1288
    Flavi_NS2A; Flavivirus non-structural protein NS2A
    pfam01349
    Location:2260 → 2503
    Flavi_NS4B; Flavivirus non-structural protein NS4B
    pfam01350
    Location:2114 → 2257
    Flavi_NS4A; Flavivirus non-structural protein NS4A
    pfam00949
    Location:1508 → 1658
    Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
    cl03065
    Location:206 → 257
    Flavi_M; Flavivirus envelope glycoprotein M
    cl38915
    Location:1831 → 1967
    DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
    pfam00869
    Location:282 → 581
    Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains
    pfam00972
    Location:2767 → 3401
    Flavi_NS5; Flavivirus RNA-directed RNA polymerase
    pfam01003
    Location:4 → 116
    Flavi_capsid; Flavivirus capsid protein C
    pfam01570
    Location:147 → 197
    Flavi_propep; Flavivirus polyprotein propeptide
    pfam07652
    Location:1678 → 1825
    Flavi_DEAD; Flavivirus DEAD domain
    pfam01728
    Location:2566 → 2733
    FtsJ; FtsJ-like methyltransferase

  2. NP_775499.1 core protein C

    Conserved Domains (1) summary
    pfam01003
    Location:4 → 96
    Flavi_capsid; Flavivirus capsid protein C

  3. NP_775500.1 anchored core protein C

    Conserved Domains (1) summary
    pfam01003
    Location:4 → 112
    Flavi_capsid; Flavivirus capsid protein C

  4. NP_775501.1 PreM protein

    Conserved Domains (1) summary
    pfam01570
    Location:21 → 94
    Flavi_propep; Flavivirus polyprotein propeptide

  5. NP_775502.1 matrix protein M

  6. NP_775503.1 envelope protein

    UniProtKB/TrEMBL
    A0A142LXI7, A0A482J0B0, A0A482J0C9, A0A482J1U8, A0A482J3K3, A0A482J593, A0A482J5M5, A0A482J6V9, A0A4Y5RYD8, E3UMJ5, E3UMJ7, E3UMK0, E3UMK2, E3UML3, E3UMN7, G1BEW5, Q77UW1, S4V7F9, S4VC21
    Conserved Domains (3) summary
    cd12149
    Location:311 → 395
    Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
    TIGR04240
    Location:400 → 496
    flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
    pfam00869
    Location:2 → 301
    Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains

  7. NP_775504.1 non-structural protein NS1

    UniProtKB/TrEMBL
    Q88482
    Conserved Domains (1) summary
    pfam00948
    Location:3 → 352
    Flavi_NS1; Flavivirus non-structural Protein NS1

  8. NP_775505.1 non-structural protein NS2a

    Conserved Domains (1) summary
    pfam01005
    Location:13 → 160
    Flavi_NS2A; Flavivirus non-structural protein NS2A

  9. NP_775506.1 non-structural protein NS2b

  10. NP_775507.1 non-structural protein NS3

    Conserved Domains (4) summary
    smart00490
    Location:377 → 466
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:190 → 331
    DEXDc; DEAD-like helicases superfamily
    pfam00949
    Location:21 → 169
    Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
    pfam07652
    Location:191 → 336
    Flavi_DEAD; Flavivirus DEAD domain

  11. NP_775508.1 non-structural protein NS4a

    Conserved Domains (1) summary
    pfam01350
    Location:4 → 126
    Flavi_NS4A; Flavivirus non-structural protein NS4A

  12. NP_775509.1 2K protein

    Conserved Domains (1) summary
    pfam01350
    Location:1 → 21
    Flavi_NS4A; Flavivirus non-structural protein NS4A

  13. NP_775510.1 non-structural protein NS4b

    Conserved Domains (1) summary
    pfam01349
    Location:1 → 244
    Flavi_NS4B; Flavivirus non-structural protein NS4B

  14. NP_775511.1 RNA-dependent RNA polymerase

    Conserved Domains (2) summary
    pfam00972
    Location:259 → 897
    Flavi_NS5; Flavivirus RNA-directed RNA polymerase
    pfam01728
    Location:55 → 222
    FtsJ; FtsJ-like methyltransferase
Nucleotide Protein
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