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sars9b ORF9b protein [ SARS coronavirus Tor2 ]

Gene ID: 1489679, updated on 7-Jul-2024

Summary

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Gene symbol
sars9b
Gene description
ORF9b protein
Locus tag
sars9b
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
SARS coronavirus Tor2 (isolate: Tor2, nat-host: Homo sapiens; patient #2 with severe acute respiratory syndrome (SARS))
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
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Genomic context

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Sequence:
NC_004718.3 (28130..28426)

NC_004718.3Genomic Context describing neighboring genes Neighboring gene ORF7a protein Neighboring gene ORF7b protein Neighboring gene ORF8a protein Neighboring gene ORF8b protein Neighboring gene ORF9a protein;nucleocapsid protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004718.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [The cloning, expression and structural analysis of putative unknown protein Orf 9b in SARS-CoV]. Li W, et al. Bing Du Xue Bao, 2009 Jul. PMID 19769160
  2. The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus. Meier C, et al. Structure, 2006 Jul. PMID 16843897, Free PMC Article
  3. Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90. Brandherm L, et al. Int J Mol Sci, 2021 Aug 26. PMID 34502139, Free PMC Article
  4. Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivo. Calvo E, et al. Virus Res, 2012 Oct. PMID 22820404, Free PMC Article
  5. SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus. Sharma K, et al. PLoS One, 2011. PMID 21637748, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90.
    Title: Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90.
  2. SARS-CoV ORF-9b manipulates host cell mitochondria and mitochondrial function to help evade host innate immunity.
    Title: SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the MAVS/TRAF3/TRAF6 signalosome.
  3. Protein 6 immunoprecipitation from extracts of SARS-CoV infected cells and mass spectrometry analysis revealed an interaction of viral proteins 6 and 9b in biologically relevant conditions.
    Title: Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivo.
  4. The structure of the Orf 9b protein consisted mostly of beta-sheet, and comprised only few alpha-helix.
    Title: [The cloning, expression and structural analysis of putative unknown protein Orf 9b in SARS-CoV].
  5. Putative virion assembly protein.
    Title: The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
ORF9b protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004718.3 Reference assembly

    Range
    28130..28426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009825062.1 ORF9b protein [SARS coronavirus Tor2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P59636, Q7T6R2
    UniProtKB/TrEMBL
    A0A3G5BJ10, B8Q8R1, B8Q8S3, B8Q8T4, B8Q8U5, B8Q8V6, B8Q8W7, C4P6R8, D2E1E3, D2E1F8, D2E231, D2E276, D3KDN5, Q19QV9, Q1T6W9, Q3S2B4, Q3ZTD0, Q4JDP4, Q692D6, Q6GYQ1, Q6R7X8, Q6RCV7, Q6RCW8, Q6RCX9, Q6RCZ0, Q6RD01, Q6RD12, Q6RD23, Q6RD34, Q6RD45, Q6RD56, Q6S8C6, Q6S8E0, Q6T1D1, Q6TPD9, Q6VA70, Q6VA81, Q6VA92, S5ZI77
    Conserved Domains (1) summary
    pfam09399
    Location:1 → 98
    SARS_lipid_bind; SARS lipid binding protein
Nucleotide Protein
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